Allyssa @allyssaphelps
PhD Candidate @ McMaster Immunology Research Centre | Food Allergy and B Cells🔬🧫 Joined January 2013-
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I got really excited by the concept of sharing the stories that go untold that exist behind every paper. Like @JustinTaylorLab, I wrote up some of the learnings that came along the way from our recent Nature Protocols paper! go.nature.com/3uR2gCk (1/2)
As @jfekoenig indicated, I wrote a “behind the paper” post trying to give credit to the people & papers that resulted in the development of this protocol. Apologies to anyone I didn’t give enough credit to! #Bcells #flowcytometry go.nature.com/3OxA5yD
As @jfekoenig indicated, I wrote a “behind the paper” post trying to give credit to the people & papers that resulted in the development of this protocol. Apologies to anyone I didn’t give enough credit to! #Bcells #flowcytometry go.nature.com/3OxA5yD
We found type 2 polarized memory B cells! (Maybe the equivalent of Th2 cells?) I am so excited to see this paper published @ScienceTM! This was a team effort pushed by myself, @allyssaphelps, @KellyBruton_ and our colleagues @ALK_net. 🧵1/18 science.org/doi/10.1126/sc…
It’s out! Check out our work that defines a type 2-polarized memory B cell subset that drives IgE responses in humans.
It’s out! Check out our work that defines a type 2-polarized memory B cell subset that drives IgE responses in humans.
Researchers with @MacDeptMed have discovered a new cell that remembers your allergies. @jfekoenig @KellyBruton_ @ALK_net @allyssaphelps @McMasterU ow.ly/ZIO950QyVUu
Cool science from our wonderful colleague’s lab and collaborators @JustinTaylorLab
Cool science from our wonderful colleague’s lab and collaborators @JustinTaylorLab
Very excited that this paper is out. It's a protocol, but it's also a lot more. There's a ton of validation data and recommendations. Great work by @allyssaphelps and Diego and a great collab with @JustinTaylorLab. A behind-the-paper and thread to follow soon! @NatureProtocols
Very excited that this paper is out. It's a protocol, but it's also a lot more. There's a ton of validation data and recommendations. Great work by @allyssaphelps and Diego and a great collab with @JustinTaylorLab. A behind-the-paper and thread to follow soon! @NatureProtocols
Delighted to announce that our study is out on BioRxiv. I feel very fortunate to have been a co-first author on this project with @KellyBruton_
Delighted to announce that our study is out on BioRxiv. I feel very fortunate to have been a co-first author on this project with @KellyBruton_
Thrilled to share a preprint from my PhD work on memory B cell plasticity in allergy. The persistence of IgE immunity critically relies upon MBCs. In this work, we show that the reservoir of allergen-specific MBCs can be reprogrammed away from an IgE fate!
Thrilled to share a preprint from my PhD work on memory B cell plasticity in allergy. The persistence of IgE immunity critically relies upon MBCs. In this work, we show that the reservoir of allergen-specific MBCs can be reprogrammed away from an IgE fate!
Very proud of my undergraduate student Allison on coming first in her first ever poster presentation 🥹
Very proud of my undergraduate student Allison on coming first in her first ever poster presentation 🥹
@allyssaphelps, a PhD candidate from the @Jordana_Lab presents her fantastic research titled “Pathogenic IgE-fated B cell memory retains functional plasticity” #Perey2023
Exciting Workshop on "Dynamics of B cell memory" at the #KSBCELLS23 co-chaired with @KimLJacobson. The memory field is moving fast! Thanks @LaidlawLab, @PChappert, Manon Termote, @allyssaphelps, @evaconde06, @JingZhixin, Haewon Sohn and @theresa_pinter for your great talks!
Check out our Brief Review on IL-4 and B cell memory, co-written by the talented Clarissa Chakma 👇
Reservoirs of allergic memory dlvr.it/SlLy4X
@McMasterU @Mac_HSGS @MacMedSci why are Biochemistry PhD students getting paid >$12,000 more than MedSci PhD students? @Ana_LPortillo medsci.healthsci.mcmaster.ca/prospective-st…
@McMasterU @Mac_HSGS @MacMedSci why are Biochemistry PhD students getting paid >$12,000 more than MedSci PhD students? @Ana_LPortillo medsci.healthsci.mcmaster.ca/prospective-st…
@Emily_YF_Feng Despite my appointment in Medicine, I take almost all my graduate students through BBS because they have more staff support. I have also paid my MedSci students BBS rates. I have raised these (and other) concerns at the IQAP review of the MedSci. You're right to push for better.
We strongly believe that graduate students deserve to be fairly compensated to match inflation, as well as feel adequately supported by administration. To begin to combat this issue, we wrote a letter to our graduate program @MacMedSci
We strongly believe that graduate students deserve to be fairly compensated to match inflation, as well as feel adequately supported by administration. To begin to combat this issue, we wrote a letter to our graduate program @MacMedSci
Would love to see @MacMedSci follow suit
Would love to see @MacMedSci follow suit
I am grateful to work with so many fantastic #WomenInSTEM at @MacImmunology
I am grateful to work with so many fantastic #WomenInSTEM at @MacImmunology
When the cell culture flasks you ordered in 2021 arrive two years later … 😳
Pablo Canales-Herreri.. @pabloimmune
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81 Followers 79 Following Student-run Twitter for the Rullo Lab @McMasterU, located in the Michael DeGroote Centre for Learning and Discovery (MDCL)🧪 Find us at: https://t.co/ciUfezdULKFrontiers in Allergy @FrontAllergy
1K Followers 1K Following We've moved! Please follow our new account @FrontImmunol for updates on Frontiers in Immunology.I am excited about the groundbreaking study published today in @NatureMedicine, in which I am a co-author: An autoantibody signature predictive for multiple sclerosis. @UNCCBiology @unccharlotte @ChancellorGaber nature.com/articles/s4159…
Excited to share our new work in @SciImmunology! We describe targeting of gut-associated lymphoid tissue (GALT) as a novel mode of action of anti-α4β7 therapy in IBD. Co-led by @mat_uzz & A. Seki @MehandruLab @SinaiImmunol @MountSinaiGI @IcahnMountSinai🧵 science.org/doi/10.1126/sc…
Excellent news for the future of Canadian science. 👏 Let’s not wait another 2 decades+ to consider the next increase in support… index to inflation! 🇨🇦🔬🧫🧬
Important changes and welcome increases to student scholarships and postdoctoral fellowships. Looks like Banting and Vanier are going away.
Marked this talk on my AAI schedule, so excited to check out the associated manuscript out in @J_Immunol today @Masopust_Vezys @stolley_michael First lung infection permanently enlarges LN to enhnace new T cell responses doi.org/10.4049/jimmun…
I am very excited to see this in print! New work from our lab defines an interferon-induced memory B cell subset during chronic viral infection. An awesome effort by Lucy Cooper @coopernatant & supported by our generous lab members & collaborators @MonashBDI @ImmunityCP
Online now: Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection dlvr.it/T5DpCg
#InterferonPower! #FriendsOrFoes! Chronic virus infections lead to memory B cells that do not protect the host. @KimLJacobson &co show @ImmunityCP that prolonged type I IFN induction in chronic infections reshapes the (epi)genetic landscape of Bmem cells! dlvr.it/T5DpCg
IFN-I governs chromatin landscape and phenotype of memory B cells during a critical early window, disrupting memory formation in chronic virus infection @KimLJacobson @ImmunityCP @coopernatant cell.com/immunity/fullt…
Just had my last undergrad presentation at the @MacImmunology Work-In-Progress Seminar. Thank you for the amazing questions and engagement. I am truly grateful for all of MIRC's support over the past couple years 💗 #immunofluorescence #microscopy #IBEX #immunology
Exciting to be helping organize our 2nd annual conference again this year! Our early bird registration closes soon, if you’re interested in NK cell and ILC research join us!!
Registration is now open for CanNKC 2024 Symposium! You won’t want to miss the trainee talks or this fantastic lineup of keynote speakers! @sarah_crome @david_raulet and Mary Carrington 2024cannkcsymposium.rsvpify.com
Divided between sending a manuscript to @NatureComms or using the publication fee money to buy snacks for my lab for three years. Wait, I guess I have a decision: accepting suggestions of journals that you all had great experiences with!
So happy to see this one out in the world. Congrats @lailashehata17 and the rest of the team!🍾
IL-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers @PepperMarion @ImmunityCP @lailashehata17 cell.com/immunity/fullt…
IL-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers @PepperMarion @ImmunityCP @lailashehata17 cell.com/immunity/fullt…
Feeling very lucky to be in Barga Italy for the 2024 Antibody Biology & Engineering @GordonConf! Looking forward to an amazing week of Ig research
Excited to share the first preprint manuscript of my postdoc w/ @PatWilsonLab1 ! Here, we assessed the evolutionary relationship between mutability, somatic hypermutation and codon optimality among germline IG genes & V(D)J repertoires. Please take a read! 1/
Mutability and hypermutation antagonize immunoglobulin codon optimality biorxiv.org/cgi/content/sh… #biorxiv_immuno
I still dream of knocking out the gene that causes lettuce to soften and calling it Salad-CRISPR
Gene editing enhances tomato shelf-life while maintaining fruit quality. Tomatoes are a valuable commodity worth $95.62 billion worldwide. ↳ Fruit losses in the supply chain vary between 25% and 42%. Consumers are looking for nutrient-rich, high-flavor, and convenient fruit.…
1/ Exciting news from the world of allergy research! We at @IgGenix published a manuscript in @jacionline on peanut allergy, with implications for novel therapeutics. Let's dive in! 🥜
Online now @Nature the final version of Sandra Nakandakari’s universal LIPSTIC paper! Thanks to @MempelThorsten and the other reviewers for their very useful input. *Special* thanks to @KamphorstAlice for stepping in to help us out! nature.com/articles/s4158…
Extremely excited to share our work using large-scale genomics to understand and unravel the genomic and evolutonary complexity in anaplastic thyroid cancer 👇👇. Thankful to all who contributed to the study and grateful for reviewers who helped us improve our work!
Delighted to finally share our 15 center collaborative ATC manuscript just published at @CellReports "The genomic, evolutionary and functional landscapes of anaplastic thyroid carcinoma" sciencedirect.com/science/articl… @TheBoutrosLab @peteryufanzeng @WesternOtoHNS @SchulichMedDent