Ramil R. NOCHE, Ph.D. @docnitephd
🇵🇭🇨🇦 Zebrafish and CRISPR-Cas expert, Life science leader, Macrophage and microglia enthusiast, polyglot Toronto, Ontario Joined January 2009-
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I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9
Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti nature.com/articles/s4158… 1/7
We’re very excited to share the first preprint from my lab along with @h4rrymcnamara, @BillZJia, @AdamEzraCohen, and Alex Schier. We describe a set of methods for exerting spatial control over Nodal signaling in zebrafish development. biorxiv.org/content/10.110…
Our first preprint as a lab is out! This one is short and sweet: We thought there had to be a faster/higher throughput way of making transgenic fish, so we set out to test if lipofection works, and it does!
Our first preprint as a lab is out! This one is short and sweet: We thought there had to be a faster/higher throughput way of making transgenic fish, so we set out to test if lipofection works, and it does! https://t.co/Uxj6O1Pvu8
2 body problem: now looking for career opportunities and will be returning soon to the Greater Toronto 🇨🇦 area to join my wife and son. Zebrafish? CRISPR-Cas? Molecular Biology? Genetics? Imaging? Project Management? All leads will be appreciated!
Tissue and Cell type Design of Synthetic Enhancers. Two papers in @Nature by the labs of @steinaerts and @AlexanderStark8 make it possible to generate enhancers a la carte. The papers: 👇 nature.com/articles/s4158… nature.com/articles/s4158…
Moving the lab to Paris in 2024, the following frozen (sperms) lines will soon be thrown away. Black, blue and red are different #InHoxWeTrust alleles. Anyone interested can contact [email protected] #NoFlowersByRequest 🙏RT genev.unige.ch/system/Duboule…
I’m thrilled to share the results of a phenomenal collaboration with Lasse Dissing-Olesen in the @stevens1lab. If you’re hungry for microglial biology and looking for a new set of utensils with which to dig in, please read on. nature.com/articles/s4146… 1/n
"PLCγ2 Variants Toggle Microglial Plaque Compactors." Thanks to @alzforum for the excellent summary of our @ImmunityCP paper! We appreciate the valuable comments from @LukensJohnR @HiltunenLab and thanks again to the team. I also hope that I have the P522R variant :)
"PLCγ2 Variants Toggle Microglial Plaque Compactors." Thanks to @alzforum for the excellent summary of our @ImmunityCP paper! We appreciate the valuable comments from @LukensJohnR @HiltunenLab and thanks again to the team. I also hope that I have the P522R variant :) https://t.co/8hrzFwjRw0
Excited to share our work in @ScienceMagazine - Kupffer cell-like syncytia replenish macrophage function to capture bacteria in a fibrotic liver. Huge congrats to lead authors @moritzpeiseler and @brunaraujodavid on their amazing work!! science.org/doi/10.1126/sc…
PUFFFIN: A novel, ultra-bright, customisable, singleplasmid system for labelling cell neighbourhoods biorxiv.org/content/10.110…
Our latest preprint is out! In a fun collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/8 biorxiv.org/content/10.110…
Sharing extraordinary work of @martincarbotano with @MLapoix @ciliaJia_jxy @wyartlab who identified the MLR in larval zebrafish, how MLR neurons encode vigor, and project onto reticulospinal neurons throughout the brainstem to elicit forward locomotion nature.com/articles/s4159…
People who fall for false information tend to be overconfident in how they think—not just what they think. Data: those who overestimate their math & reasoning skills are more susceptible to conspiracy theories. Critical thinking requires a healthy diet of intellectual humility.
A comparative analysis of microglial inducible Cre lines dlvr.it/SvLFNk
Exciting news!!😀💥 Our work with @FeijooCarmen and @SMBurgessLab is out in @NatureComms 🎉 We investigated ontogenetic hematopoietic diversity of neutrophils in zebrafish 🦓🐟 What did we find? 🧵👇 #NewPublication #zebrafish #hematopoiesis nature.com/articles/s4146…
America's antivaxx crisis: a quarter believe MMR shot causes autism; a third think Covid vaccines kill. It’s extraordinary, despite my battling antivaccine activism daily for 2 decades. The disinformation machine is so powerful and now backed politically dailymail.co.uk/health/article…
We @AcadSinica are recruiting for junior PIs!! 😃😃😃
We @AcadSinica are recruiting for junior PIs!! 😃😃😃
Ang paniniwala ni Ninoy Aquino: lahat tayo ay may kakayanan na patuloy na mahalin, ipaglaban, at itaguyod ang mahal nating Pilipinas. Tanging sa pagkakaisa nating lahat nakasalalay ang pagtamasa ng tunay na kalayaan. #SalamatNinoy #RememberingNinoy #HindiKaNagiisa
😌Si l’agenda de nos #enseignements ne vient pas à l’auditeur 😌L’auditeur vient à notre #agenda 👉 college-de-france.fr/fr/agenda?f%5B…

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