Giovanni Pascarella @mokurai79
Research Scientist @ RIKEN IMS riken.jp/en/research/la… Tokyo Joined April 2009-
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Giovanni Pascarella retweeted
Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process? In our new @Nature paper now in print, we show WGD continuously shapes tumor evolution and immune evasion. nature.com/articles/s4158…
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Giovanni Pascarella retweeted
fascinating new paper on RNA-seq analysis from living human brain tissue, which differs from results found in preserved/autopsied samples nature.com/articles/s4138…
Giovanni Pascarella retweeted
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development dlvr.it/TMdp9S
Giovanni Pascarella retweeted
One of the most complex regions in the human genome revealed. To me, it was fascinating to combine genome assembly and pangenome graphs (PGR-TK in Fig. 3e) algorithm techniques to uncover the hidden diversity across human populations. #genomics #bioinformatics
Giovanni Pascarella retweeted
Very glad to see this preprint by @lh3lh3 and @meyersonlab confirming our finding of artifactual fold-back INV in long reads (Fig S1 in our @naturemethods paper presenting #SAVANA, which filters such artifacts to improve SV calling, hence their relevance nature.com/articles/s4159…
Very glad to see this preprint by @lh3lh3 and @meyersonlab confirming our finding of artifactual fold-back INV in long reads (Fig S1 in our @naturemethods paper presenting #SAVANA, which filters such artifacts to improve SV calling, hence their relevance nature.com/articles/s4159… https://t.co/ufL3hKZXB7
Giovanni Pascarella retweeted
New online! Structural variants in the 3D genome as drivers of disease bit.ly/44FiIo5
Giovanni Pascarella retweeted
What a mind-blowing week for AI in biology! 🚀 Xaira just dropped the largest genome-wide perturbation dataset ever last week 🧬 Arc unveiled STATE yesterday, the most powerful foundation model for single-cell perturbation prediction 🧠 DeepMind followed up with AlphaGenome,…
Giovanni Pascarella retweeted
Architectural RNAs: blueprints for functional membraneless organelle assembly dlvr.it/TLKTCW
Giovanni Pascarella retweeted
Direct detection of 8-oxo-dG using nanopore sequencing. #DNAmodifications #Nanopore #Sequencing @nanopore @NatureComms nature.com/articles/s4146…
Giovanni Pascarella retweeted
We made a huge poster that illustrates all of the major genome editing tools in one place. You can download a copy for free from the @AsimovPress website. press.asimov.com/articles/crisp…
Giovanni Pascarella retweeted
Thrilled to see #SAVANA out in @naturemethods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s4159…
Another amazing discovery about something amazing that repeat elements do! cell.com/cell/fulltext/…
Giovanni Pascarella retweeted
New online! Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq bit.ly/4ddqzfj
Giovanni Pascarella retweeted
Where does Alzheimer’s begin in the brain? Our new study in @NeuroCellPress reveals that earliest changes start deep in cortical layers 5/6, selectively affecting parvalbumin interneurons via reduced NPTX2 & GluA4. Restoring NPTX2 reversed deficits. cell.com/neuron/fulltex…
Giovanni Pascarella retweeted
LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis | Science Advances science.org/doi/10.1126/sc…
Giovanni Pascarella retweeted
New online! Advances in single-cell DNA sequencing enable insights into human somatic mosaicism bit.ly/3EGIyxQ
Giovanni Pascarella retweeted
What are the key differences between the two new Parkinson's stem cell trials just published in Nature? What should you be thinking about when making decisions about potentially enrolling in stem cell research trials for Parkinson's. Key Points: - One study used induced…
Giovanni Pascarella retweeted
3D genome folding in epigenetic regulation and cellular memory dlvr.it/TK5tsW
Giovanni Pascarella retweeted
Perturb-tracing integrates CRISPR screening with barcode readout and chromatin tracing for loss-of-function screens, facilitating the study of chromatin folding regulators. @SStevenWang @YaleMed @Yale @YaleGenetics @YaleCellBio nature.com/articles/s4159…
Giovanni Pascarella retweeted
Is the genome just a bag of genes? A new paper in @ScienceMagazine now reports that for two thirds of an organisms' genes the position along the chromosome is actually very tightly constrained! Amazing work from my favorite night scientist @MartinJLercher and his team!
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