Sriram Neelamegham @neel_lab
Biomolecular Engineering, Systems Glycobiology, Human Diseases, Univ. Buffalo/SUNY-Buffalo, NY (@neel-lab.bsky.social) virtualglycome.org Buffalo, NY Joined June 2020-
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Sriram Neelamegham retweeted
PepMLM is out in @NatureBiotech! 🎭Want a short binder for any target? Just input its sequence + desired binder length → PepMLM unmasks it. Simple? No way? The results speak for themselves. 👇 📜: nature.com/articles/s4158… 💻: github.com/programmablebi… 🤗: huggingface.co/ChatterjeeLab/……
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Happy to share our paper in "Small" on a new method for high-throughput engineering of glycoEnzymes, studies of enzymes from different species etc. "Mammalian Cell Surface Display for High‐Throughput Protein Engineering of Glycosyltransferases" onlinelibrary.wiley.com/doi/10.1002/sm…
Sriram Neelamegham retweeted
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer. #glycotime Great work @eduleitegomes @i3S_UPorto @GlycanTrigger academic.oup.com/ecco-jcc/artic…
Sriram Neelamegham retweeted
📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in #microarrays, #Luminex (bead based arrays) and #ELISA assays. Check it out in @ACSCentSci doi.org/10.1021/acscen… #glycotime #clickchemistry
Elegant model system to study thromboinflammation
Sriram Neelamegham retweeted
Not just xylose on O-glucose of EGF domains! „Interestingly, the loss of pentose elongation states was compensated for by a higher relative abundance of the Hex(2)-NeuAc trisaccharide.“
Not just xylose on O-glucose of EGF domains! „Interestingly, the loss of pentose elongation states was compensated for by a higher relative abundance of the Hex(2)-NeuAc trisaccharide.“
Sriram Neelamegham retweeted
Carbohydrates GRC This year's conference list has not yet met the registration goal, which is important for the continuity of this GRC. my.grc.org/p/contribution…
Sriram Neelamegham retweeted
📢𝐒𝐀𝐕𝐄 𝐓𝐇𝐄 𝐃𝐀𝐓𝐄: The @GlycanTrigger Scientific Symposium will take place in Porto in 2026 📍 i3s, Porto, Portugal (in-person) 📅 Sept 24-25, 2026 𝗦𝘁𝗮𝘆 𝘁𝘂𝗻𝗲𝗱 𝗳𝗼𝗿 𝗺𝗼𝗿𝗲 𝗱𝗲𝘁𝗮𝗶𝗹𝘀! #glycotime #i3s #HorizonEurope
So insightful!
Pleased to share our paper in NAR on mRNA delivery to mouse lungs using SARS2 VLPs: " Tuning the tropism and infectivity of SARS-CoV-2 virus-like particles for mRNA delivery" academic.oup.com/nar/article/53…
Sriram Neelamegham retweeted
Please help us spread the word about the extension! @euroglyco @ozglyco @GLYCOTwinning @Glyco_Alps @glyco_pm
Please help us spread the word about the extension! @euroglyco @ozglyco @GLYCOTwinning @Glyco_Alps @glyco_pm
Sriram Neelamegham retweeted
Scientists found that key glycans on the SARS-CoV-2 spike protein are vital for infection and cell fusion. Removing them stopped the virus, pointing to a potential target for pan-coronavirus treatments. nature.com/articles/s4429…
Sharing link to our paper: "Conserved Role of Spike S2 Domain N-glycosylation Across Betacoronaviruses", now published in @Nature_NPJ #npjViruses. The paper highlights that #Glycotime is critical for all tested beta-CoVs, not just #SARS-CoV-2! nature.com/articles/s4429…
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