second scight empowers biotech and pharma companies with comprehensive data consulting services to accelerate drug developmentsecondscight.com Strasbourg, FranceJoined April 2024
Today, #Europe, @EmmanuelMacron and 🇫🇷 have once again demonstrated that there are useless, weak, and irrelevant. I fear that #Europe will collapse once and for all. I am not proud of my country.
Today, #Europe, @EmmanuelMacron and 🇫🇷 have once again demonstrated that there are useless, weak, and irrelevant. I fear that #Europe will collapse once and for all. I am not proud of my country.
The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science.
Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving 4–22% success rates with efficient experimental…
Oncolytic viruses have the unique ability to selectively replicate within (and to destroy) cancer cells, offering a promising approach in cancer treatment.
A new Review summarises clinical progress, remaining challenges, & future research directions: hubs.li/Q03K5DlW0
A new benchmark for deep learning based affinity prediction: Solving the inter-protein scoring noise problem
1. Researchers from the University of Münster have introduced a novel benchmark for evaluating deep learning models' ability to predict protein-ligand binding affinities,…
10 Rules for a Structural Bioinformatic Analysis
1. The Protein Data Bank (PDB) is a treasure trove of over 277,000 macromolecular structures. This article outlines 10 essential rules for leveraging PDB data in structural bioinformatics to uncover new biological insights. The…
Less than two years after breaking ground on a $1.3 billion R&D center and future U.K. headquarters in London, Merck & Co. is bailing on the project and discontinuing all research operations in Britain, citing an unwelcoming business environment. $MRK fiercebiotech.com/biotech/merck-…
For readers interested in cancer therapies, this review discusses how metabolic dysfunction of CD8 T cells and NK cells can diminish their anticancer activity, and assesses therapeutic strategies to overcome this nature.com/articles/s4157…rdcu.be/eFqm2
Mechanotransduction in the nucleus
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
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Regular exercise reduces the likelihood of plaque accumulation in the arteries
However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression
The fascinating thing is that despite the higher plaque, those people still…
🇨🇳5 Things BeiGene Can Teach Us About the Future of China-Driven Biotech
If you want to understand where biotech R&D is going, don’t just look to Boston.
Look to BeiGene.
They’ve quietly built one of the most ambitious, vertically integrated R&D engines anywhere in the world.…
Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicagonature.com/articles/s4158…
Another $2B COPD opportunity just hit a brick wall.
Yesterday, the Roche / Amgen IL-33 Astegolimab missed its primary endpoint in the Ph3 ARNASA study - the second failure of an IL-33 in a few months, after the Regeneron / Sanofi AERIFY-2 study of Itepekimab failed in May…
MOPPIT: De Novo GENERATION OF MOTIF-SPECIFIC PEPTIDE BINDERS VIA CONDITIONAL UNIFORM DISCRETE DIFFUSION
Researchers have introduced moPPIt, a novel algorithm for the de novo generation of motif-specific peptide binders. This method is particularly significant as it can design…
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35K Followers 813 FollowingCreator of SciPy, NumPy, and Numba; founder of Anaconda, Inc and NumFOCUS. CEO of Quansight, OpenTeams, and OpenTeams Global, Head of Product at Zyphra
2K Followers 165 FollowingHope Through Rigorous Science
Our mission is to discover, create, test and deliver transformative medicines to treat patients with genetic diseases. $BBIO
48K Followers 2K FollowingChief AI & Co-founder @AnacondaInc; invented @pyscript_dev, @PyData @Bokeh @Datashader. Former physicist. A student of the human condition. bsky: @wang.social
75K Followers 704 FollowingA community for developers and users of open source scientific tools with 200K+ people 🧑🔬 🧑💻, by @NumFOCUS. Join our Discord: https://t.co/rmBFaQvdMM
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31K Followers 299 FollowingJournalist @ ApexOnco. The Wolverine Of Biotech / Mr ASH. Once had a blue tick. Interested in: oncology. Not interested in: what stock you bought today.
96 Followers 550 FollowingFounded in 2024, we believe in a future where diseases aren't merely controlled—they're cured.
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16K Followers 2K FollowingThe leading voice for decision-makers throughout the global biopharma ecosystem. Follow us on LinkedIn for exclusive insights & analysis: https://t.co/V33Z1gfUfZ
508 Followers 220 FollowingSPARK is a partnership between academia and industry dedicated to translating academic discoveries into drugs or diagnostics that address real clinical needs
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908 Followers 179 FollowingAssociate Professor at @Ludwig_Cancer @UNIL. Excited by computational biology applied to immunology and cancer. Retweet != Endorsement.
6K Followers 347 FollowingLearn to invest in biotech like the professionals from a former biotech executive and investment banker. For education purposes only. Course on Thinkific
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35K Followers 289 FollowingExpert editorial commentary, research highlights, and perspectives across all scientific fields from the team behind the Advanced Portfolio by Wiley.
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