Alex Walker @AlexWalkerPath
Postdoc with @PeterJCullen @BristolBiochem, formerly postdoc @YamauchiLab @CMMBristol and DPhil Student @fodorlab @Dunn_School. Biology 🦠🧬 and food! 🍕🥐 Joined August 2019-
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Really glad to contribute to this work led by the crazy-talented (although not on social media!) Rebeka Butkovic 🎉 An exciting first step into the fascinating world of cell biology! 🧪🧫
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Alex Walker retweeted
Using virion vRNPs, together with purified proteins, we have, for the first time, recreated the switch from influenza virus transcription to replication, AND a full cycle of genome replication inside a test tube🧪@AmandaZihanZhu @haitian_fan @PLOSBiology ➡️journals.plos.org/plosbiology/ar…
Alex Walker retweeted
Delighted to share that our structure of the endosomal Commander complex is now published in @CellCellPress! cell.com/cell/fulltext/…
Alex Walker retweeted
The tale of influenza viruses Part II: Molecular Replication, sister to its transcription-focused Part I, is now aired online in Trends in Microbiology! Click here ⬇️ to check out the most recent structural updates on influenza virus genome replication! sciencedirect.com/science/articl…
Ready for #NSV2022 after a cancelled flight led to an unexpected journey to Heathrow airport! ✈️ Excited to catch up with old friends and make some new ones!
Alex Walker retweeted
Our study on a novel role of host factor ANP32 in influenza virus genome replication has been published on @NAR_Open academic.oup.com/nar/advance-ar…, congrats everyone involved @FangzhengWang @Dr_Shepp @StallerEcco @wendybarclay11 @jonathan_grimes @fodorlab @Dunn_School @OxfordStrubi!
Glad to see this out, congrats everyone!
Our NSP14 baby academic.oup.com/nar/advance-ar… is finally out today @NAR_Open. Can't thank @JeremyKeown1 @haitian_fan from @fodorlab and @jonathan_grimes lab, @SchofieldOxford , @ogileadi and McHugh lab enough for their support and hard work to get this to the finish line ❤️.
Alex Walker retweeted
In a world where viruses, scientists and llamas co-exist…. happy to share our work in collaboration with Grimes' lab, on mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies produced in llamas. Check it out! nature.com/articles/s4146…
Alex Walker retweeted
Really happy to see this piece of work out. With @amandaz83411502 we structurally and functionally characterised 24 nanobodies against the 1918 influenza virus polymerase. @fodorlab @jonathan_grimes @OxfordStrubi @Dunn_School rdcu.be/cELs3
Just out today, our contribution to understanding #SARSCoV2! We show that the viral polymerase is involved in capping the viral RNA. With thanks to @fodorlab @haitian_fan @JeremyKeown1 @M_L_Knight @jonathan_grimes academic.oup.com/nar/advance-ar…
Alex Walker retweeted
It's Flu awareness week and @DiamondLightSou arranged for an animation of some of our recent work on the influenza polymerase. @CarriqueLoic @AlexWalkerPath @jonathan_grimes @fodorlab @StallerEcco @OxfordStrubi @Dunn_School
@WHO_Europe This animation with @UniofOxford explores how the flu virus interacts with our bodies. Knowing the structure and function of this stabilising protein will enable scientists to work on new treatments to fight the disease. @STFC_Matters @BBSRC @wellcometrust
Alex Walker retweeted
Congratulations to Alex @AlexWalkerPath on passing his DPhil viva @Dunn_School ! Enjoy your postdoc in Bristol with @YamauchiLab !
Alex Walker retweeted
Nice work @M_L_Knight @haitian_fan @fodorlab @OxfordStrubi.
Michael L. Knight et al.: Structure of an H3N2 influenza virus nucleoprotein #Influenza #RNABindingProtein #Nucleoprotein @UniofOxford ... #IUCr scripts.iucr.org/cgi-bin/paper?…
Alex Walker retweeted
Alex @AlexWalkerPath from @Dunn_School presents his work on SARS-CoV-2 RNA capping at @MicrobioSoc #Microbio21. See biorxiv.org/content/10.110… for details.
New preprint alert 🚨 Our latest SARS-CoV-2 work, showing that one of the domains in the viral RNA polymerase is an enzyme involved in viral RNA capping (and this reaction is inhibited by remdesivir TP)!
Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase disq.us/t/3vmk30i
Alex Walker retweeted
Another stunning talk from @AlexWalkerPath on how 'mutation of a Flu polymerase 3' RNA promoter binding site inhibit transcription elongation' was delievered! Great work! #IUM2020 #Influenza
Alex Walker retweeted
Socially distanced cake celebration for our @nature paper nature.com/articles/s4158… 🎉 Congratulations again to all first authors @CarriqueLoic @haitian_fan @JeremyKeown1 @AlexWalkerPath @jonathan_grimes and Ervin! #influenza #cake
We present the first structures of influenza virus polymerase bound to an essential host factor, and these give us some amazing insights into how the #flu virus replicates/adapts for new hosts! Congratulations everyone @CarriqueLoic @haitian_fan @JeremyKeown1 @jonathan_grimes
nature.com/articles/s4158… @CarriqueLoic @haitian_fan @AlexWalkerPath @jonathan_grimes #notontwitterErvin. We solved a series of structures using #cryoEM of the ANP32-Influenza polymerase complex, and investigated it using functional assays. @OxfordStrubi @Dunn_School @NDMOxford
Alex Walker retweeted
Many congratulations to all the winners at today's Graduate Student Symposium! 🏅🏅🏅 1st year poster prize: Shengpan Zhang (Sattentau group) 2nd year poster prize: @RuthKetley (Gullerova group) and @lu_fangfang (@freeman_lab) 3rd year talk prize: @AlexWalkerPath (Fodor Group)
Alex Walker retweeted
Our virtual progress seminars continue! Last week Nandita Bodra @LeaLabTweets talked about structural work on the complement system. Yesterday, Florian Zobel @IvanAhelLab discussed PARP1 and tomorrow @AlexWalkerPath (Fodor lab) tell us more about his #COVID19 research
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