Compound Researcher @Compoundarxiv
What we're researching @compoundvc | DM @mhdempsey @shelbynewsad @0xsmac @mackenziejem to discuss Joined July 2020-
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Multi-cell elastocaloric cooler stacks compressive tubular NiTi to deliver kW-scale cooling (1.28 kW) and 500k-cycle durability; graphene nanofluid boosts heat transfer—pushing solid-state air-conditioning toward practical use. nature.com/articles/s4158…
ThERMO: thermal-imaging feedback optimizes electrosurgical tool speed to curb heat injury while maintaining cut force. In phantoms, delivers 3× higher success and ~2× lower peak force—toward safer robotic surgery. arxiv.org/abs/2509.19725
PRL shows giant magnetoresistance in an electrically gated 2D van-der-Waals antiferromagnet (CrSBr), enabling a ‘magnetic transistor’ fusing logic+nonvolatile memory and promising ultra-low-power in-memory/spintronic computing. journals.aps.org/prl/abstract/1…
Read with full footnotes here: michaeldempsey.me/blog/2025/09/2…
(New essay) Narrative Cycle Entry A core reality for founders is that narrative timing has become a first-order strategic decision that demands the same rigor as product, GTM, or research. When announcing their company, founders should be aware of the point in the narrative…
Operando interlayer expansion (e-IE) in rapid-annealed multiscale curved graphene lets ions enter galleries; pouch-cell supercapacitors hit 99.5 Wh/L, 69.2 kW/L (IL) and 49.2 Wh/L (organic). Implication: compact, fast-charge EV/electronics storage. chatgpt.com/c/68cc19e0-39d…
PU.1/IRF8/BATF3 delivered by adenovirus reprograms tumor cells in vivo into cDC1-like APCs, driving T-cell infiltration and tumor regressions. Enables off-the-shelf in situ cancer vaccine; aligns with Asgard’s AT-108 program. science.org/doi/10.1126/sc…
Explains why LLM features form manifolds: cosine similarity encodes on-manifold geodesic distance. Validated on embeddings/token activations. Implications: principled interpretability, safer editing, improved retrieval/steering. arxiv.org/abs/2505.18235
Boosting proteasome regulator PI31 restores synaptic proteasome transport and prevents neurodegeneration in Fbxo7/PARK15 parkinsonism. Suggests PI31 upregulation (gene therapy/small molecules) as a disease-modifying PD therapy. pnas.org/doi/10.1073/pn…
Aluminum electrification slashes CO₂-abatement costs vs steel (~$9 vs $363/t CO₂ in 2050), making low-carbon aluminum a cost-effective substitute for steel in many applications if renewable power is cheap chemrxiv.org/engage/chemrxi…
Introduces Infiltrated Selfish Mining, a new pooled Bitcoin mining attack that avoids the miner’s dilemma, enabling win-win collusion among pools. Easier than PAW/FWAP yet more profitable than FAW. Authors propose a punishment-based countermeasure. dl.acm.org/doi/10.1145/37…
Hybrid quantum–classical photonic protocol enables dynamic routing of high-fidelity entanglement over existing fiber via classical headers + real-time error mitigation, advancing scalable quantum internet with current telecom infra. science.org/doi/10.1126/sc…
smFC integrates oblique plane microscopy + microfluidics for true single-molecule flow cytometry, lowering detection to ~2 fluorophores/cell (10–80× better). Enables digital quant of rare biomarkers, low-abundance targets in oncology/diagnostics. biorxiv.org/content/10.110…
AI framework combining genetic algorithms + VAEs generates de novo antibiotics; 7/24 active, 2 novel leads effective vs MDR N. gonorrhoeae & S. aureus in vivo cell.com/cell/abstract/…
Allogeneic P1 in lupus shows remission CRISPR-Cas9 knockout of TRAC, PD1, HLA-A, HLA-B, CIITA and precise TRAC-locus insertion of CD19-targeting STAR in hypoimmune allogeneic T cells (YTS109) enables stealth, physiologic TCR-like CD19 targeting nature.com/articles/s4159…
Sophisticated Consumers with Inertia: Long-Term Implications from a Large-Scale Field Experiment papers.ssrn.com/sol3/papers.cf…
The Churn Dynamics of Young Brands papers.ssrn.com/sol3/papers.cf…
Chemical-proteomics platform employs bioorthogonal cysteine-reactive IA-mTz and analog probes to induce intracellular protein modification, validate presentation as MHC-I covalent neoantigens, and enable bioorthogonal Fc-mediated immune recruitment biorxiv.org/content/10.110…
Liposomes with GRAS‑approved sucrose alter core acoustic impedance, enabling focused‑ultrasound‑triggered release of diverse drugs in vitro and in vivo neuromodulation—clinically translatable site‑targeted pharmacology. nature.com/articles/s4156…
nicole ruiz @nwilliams030
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Michael Dempsey @mhdempsey
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🇮🇱🇺🇦🇹�... @alt1na1
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1K Followers 2K Following Ideas don’t fail – teams do. Building @getclera to help exceptional founders build their team of A players. | CTO & Cofounder
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Michael Dempsey @mhdempsey
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Maximum Sparsity Rein... @MaxDiffusionRL
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Mackenzie Morehead @mackenziejem
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smac @0xsmac
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Ali Madani @thisismadani
7K Followers 1K Following Founder & CEO of Profluent (https://t.co/GpoVdKW1zQ, we're hiring!). AI+Biology to cure disease. Berkeley PhD. formerly Research @ Salesforce AI.
Rob Hurt @robertchurt
396 Followers 727 Following Synthetic biology postdoc in Pete Schultz’s lab @scrippsresearch | Neurobiology PhD @Caltech with @mikhailshapiro
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Nature Biotechnology @NatureBiotech
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@arxivblog @arxivblog
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Compound @CompoundVC
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