Compound Researcher @Compoundarxiv
What we're researching @compoundvc | DM @mhdempsey @shelbynewsad @0xsmac @mackenziejem to discuss Joined July 2020-
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Aluminum electrification slashes CO₂-abatement costs vs steel (~$9 vs $363/t CO₂ in 2050), making low-carbon aluminum a cost-effective substitute for steel in many applications if renewable power is cheap chemrxiv.org/engage/chemrxi…
Introduces Infiltrated Selfish Mining, a new pooled Bitcoin mining attack that avoids the miner’s dilemma, enabling win-win collusion among pools. Easier than PAW/FWAP yet more profitable than FAW. Authors propose a punishment-based countermeasure. dl.acm.org/doi/10.1145/37…
Hybrid quantum–classical photonic protocol enables dynamic routing of high-fidelity entanglement over existing fiber via classical headers + real-time error mitigation, advancing scalable quantum internet with current telecom infra. science.org/doi/10.1126/sc…
smFC integrates oblique plane microscopy + microfluidics for true single-molecule flow cytometry, lowering detection to ~2 fluorophores/cell (10–80× better). Enables digital quant of rare biomarkers, low-abundance targets in oncology/diagnostics. biorxiv.org/content/10.110…
AI framework combining genetic algorithms + VAEs generates de novo antibiotics; 7/24 active, 2 novel leads effective vs MDR N. gonorrhoeae & S. aureus in vivo cell.com/cell/abstract/…
Allogeneic P1 in lupus shows remission CRISPR-Cas9 knockout of TRAC, PD1, HLA-A, HLA-B, CIITA and precise TRAC-locus insertion of CD19-targeting STAR in hypoimmune allogeneic T cells (YTS109) enables stealth, physiologic TCR-like CD19 targeting nature.com/articles/s4159…
Sophisticated Consumers with Inertia: Long-Term Implications from a Large-Scale Field Experiment papers.ssrn.com/sol3/papers.cf…
The Churn Dynamics of Young Brands papers.ssrn.com/sol3/papers.cf…
Chemical-proteomics platform employs bioorthogonal cysteine-reactive IA-mTz and analog probes to induce intracellular protein modification, validate presentation as MHC-I covalent neoantigens, and enable bioorthogonal Fc-mediated immune recruitment biorxiv.org/content/10.110…
Liposomes with GRAS‑approved sucrose alter core acoustic impedance, enabling focused‑ultrasound‑triggered release of diverse drugs in vitro and in vivo neuromodulation—clinically translatable site‑targeted pharmacology. nature.com/articles/s4156…
Agentic commerce: AI agents shop, but tests show SOTA models fail rationality, are placement-biased; weigh price/ratings unevenly by AI. Seller AIs will game them, causing SEO-style slop. Needs deep personalization to user prefs. arxiv.org/abs/2508.02630
Electrochemical CO2 capture/storage system using vanadium & ferricyanide couples achieves 54 kJ/mol CO2 via pH-swing, doubles as battery for day-night operation, avoids precious metals, oxygen tolerant, scalable via VRFB design. Capture cost of $70/ton CO2 pubs.acs.org/doi/10.1021/ac…
Saliva liquid biopsy: m-eLB uses EFIRM-based, non-PCR/non-NGS electrochemical microsensor array to multiplex-detect ultra-short ctDNA in single droplet with AUC ≈0.93-0.98 — enabling rapid minimal-volume lung cancer liquid biopsy. mdpi.com/1422-0067/24/1…
Scalable CoCe-MOF synthesis enables alkaline water splitting at 4.11 kWh Nm⁻³ H₂ with 5,000 h stability; lattice distortion/large surface area boost catalysis/transport. Initial TEA indicates $2.71 kg⁻¹ H₂ (near DoE's target)+ 84% lower CO₂ than gray nature.com/articles/s4428…
Meta's Reality Labs develop centimeter-scale visible PICs to enable 2-mm-thick flat-panel laser displays with 211% color gamut, >80% volume reduction vs LCoS; demoed in AR, enabling slim immersive/holographic displays nature.com/articles/s4158…
ION224 antisense inhibition of +DGAT2 in liver significantly improved NAS without fibrosis worsening in MASH (46–59% vs 19% placebo) in Ph2 trial; safe/tolerated. thelancet.com/journals/lance…
Subcutaneously injectable protein microparticle platform using polyacrylamide copolymer enables >500 mg/mL stable formulations through spray-drying; maintains efficacy/PK, allowing SC autoinjector delivery, expanding drug accessibility. science.org/doi/10.1126/sc…
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