Fraternali Lab @FraternaliLab
Bioinformatics & Computational Biology @ University College London @ISMBInstitute @ucl fraternalilab.github.io London, England Joined March 2018-
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Great talks by both Oriol and Joseph at #ELIXIR #3dBioinfo meeting at Barcelona!
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Fraternali Lab retweeted
Another preprint @FraternaliLab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab @ffrancafrat @SophiaKaragiann biorxiv.org/content/10.110…
🚨 New preprint on our new approach (IndeLLM) to score pathogenicity of insertions/deletions biorxiv.org/content/10.110…
Fraternali Lab retweeted
Happy to share new work @FraternaliLab led by @Dongjun_Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.
Proud to be part of this exceptional mentoring programme💪 @ELIXIREurope
Joseph on sciCSR to study and infer class switching dynamics in B cells using scRNA-seq data #ISMB2024
Dongjun's talk on ImmunoMatch a.k.a. antibody "tinder" to study heavy and light chain pairing at 3DSIG! #ISMB2024
Oriol's talk on addressing biases in variant impact prediction at VarI #ISMB2024
Fraternali Lab retweeted
Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the @iit_ucl symposium 2024 🎉👏
Fraternali Lab retweeted
We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7) 📄biorxiv.org/content/10.110… 🌐fraternalilab.cs.ucl.ac.uk/VCAb/
Fraternali Lab retweeted
Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with @FraternaliLab @Mauri_group jobs.surrey.ac.uk/Vacancy.aspx?r…
Fraternali Lab retweeted
Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM
Xmas gift 🎁 came early for us: New review came out on @COSB_CRSB where we talked about structures of different antibody isotypes & how to model and study them! Feat. a great deal of fun drawing antibodies in the style of ladders and snakes! Free access at authors.elsevier.com/c/1iHZn,LqArQC…
Xmas outing feat. a walk across Hertfordshire countryside on a cold wintery day followed by pub!
Fraternali Lab retweeted
Very proud to finally see this recent work from my lab out in Nature Methods! Thanks to a fantastic collaborator like @JosefNg1 and an enthusiastic group of Immunologists! nature.com/articles/s4159…
Fraternali Lab retweeted
Very happy that sciCSR - our new method in analysing B cell Class-Switch Recombination (CSR) in #scrnaseq data - is out @naturemethods - Tweetorial below 🧵
Very happy that sciCSR - our new method in analysing B cell Class-Switch Recombination (CSR) in #scrnaseq data - is out @naturemethods - Tweetorial below 🧵
Fraternali Lab retweeted
sciCSR developed by @FraternaliLab, @JosefNg1 and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics. nature.com/articles/s4159…
Fraternali Lab retweeted
CCPBioSim Biomolecular Simulation at this week's workshop Thanks to all the trainers that helped in making this a success! on #structuralbioinformatics resources and tools for #moleculardynamics simulations. The course is run in association with CoSeC UKRI and STFC.
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