Gan Lab @LiGanLab
Group of enthusiastic scientists studying how maladaptive immune responses and mishandling of proteins contribute to Alzheimer's disease. Managed by lab members appel.weill.cornell.edu/labs/gan-labor… New York Joined July 2019-
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Congratulations @CelesteParraB on winning 2nd place for her oral presentation on her recently published work understanding the modifiers of 4R-tau aggregation in hiPSC-derived neurons at the 43rd Vincent Du Vigneaud Symposium! @WeillCornellGS @WeillCornell @WCM_BMRI
A huge congratulations to Dr. Gan for receiving the 2024 Jessica M. and Natan Bibliowicz Award for Excellence in Mentoring Women Faculty! It is a pleasure to receive your guidance daily in our lab. @WeillCornell #WCMDiversityWeek diversity.weill.cornell.edu/about-us/diver…
Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s disease: Cell Reports cell.com/cell-reports/f…
Drumroll please...We're excited to announce the launch of our official lab website!! Explore and keep up with our research, socials, lab news and other key information here!: ganlab.org
Congratulations to our postdoc, Wenhui Qu, for receiving the @_BrightFocus postdoctoral fellowship award in Alzheimer’s disease! What a great way to wrap up your first year in the lab, with excitement for discoveries to come!
New frontiers in the cGAS-STING intracellular DNA-sensing pathway: Immunity cell.com/immunity/fullt…
The conceptual foundations of innate immunity: Taking stock 30 years later dlvr.it/T5VGNs
Now Online Modelling tauopathies dlvr.it/T5H8sZ
Now online! Human iPSC 4R tauopathy model uncovers modifiers of tau propagation dlvr.it/T57TDx
Thrilled to share our latest research published in Nature Methods! We have developed improved green and red serotonin sensors for sensitive and dual-color monitoring of serotonin dynamics in vivo. Check out the full paper here: nature.com/articles/s4159…
Leaky blood-brain barrier in long-COVID associated brain fog This study confirms everything I have seen in the microscope over the last few years. They use a technique called dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), an imaging technique that can measure…
STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges @NeuroCellPress cell.com/neuron/fulltex…
Tau depletion in human neurons mitigates Aβ-driven toxicity: nature.com/articles/s4138…
Amyloid as the earliest detectable marker for Alzheimer's Disease. Just released a multicenter, case–control study of #Alzheimer’s biomarkers in cognitively normal participants from Jan 2000 through Dec 2020. These participants underwent testing of cerebrospinal fluid (CSF),…
John Lukens @LukensJohnR
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Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s disease: Cell Reports cell.com/cell-reports/f…
Congratulations to our postdoc, Wenhui Qu, for receiving the @_BrightFocus postdoctoral fellowship award in Alzheimer’s disease! What a great way to wrap up your first year in the lab, with excitement for discoveries to come!
New frontiers in the cGAS-STING intracellular DNA-sensing pathway: Immunity cell.com/immunity/fullt…
Microglia pack a toolbox for life dlvr.it/T5T4WM #immunology
In the latest issue! Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria dlvr.it/T5T4F7
The conceptual foundations of innate immunity: Taking stock 30 years later dlvr.it/T5VGNs
Congratulations to Dr. Chandra, winner of the @yalegsas 2024 Graduate Mentor Award for the Biological Sciences! @YaleNeuro @Yale_INP
Please read this article written by my @_BrightFocus colleague, Director of Neuroscience Programs, Dr. @sharyn_rossi. brightfocus.org/alzheimers/new… highlighting innovative #Alzheimersresearch of @TommyKakari @laura_actg @HebrewU @gmbreads @FNIH_Org @kbhengen @ArielGilad & more X-less.
Innate immune activation in neurodegenerative diseases: @ImmunityCP cell.com/immunity/fullt…
If you were looking for evidence that isoforms are cool, all-pervasive in the 🧠, and everybody should study them at the single cell level, our work on mouse development and brain-region variability from the @hagentilgner lab is now live @NatureNeuro! 1/ nature.com/articles/s4159…
Now Online Modelling tauopathies dlvr.it/T5H8sZ
Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1 dlvr.it/T5BW47
Finally out!! In collaboration with the Hetzer lab @ista, we found long lived RNAs in the brain. New door is now open. Congrats Sara and Asako;) More to come soon😚 Lifelong persistence of nuclear RNAs in the mouse brain | Science science.org/doi/10.1126/sc…
Now online! Human iPSC 4R tauopathy model uncovers modifiers of tau propagation dlvr.it/T57TDx
Our MSTPs @alexanderjledet (co-mentored with @EAriasLab), @PhilDmit and Sandra showcased their posters and Greg gave a talk @EinsteinMed MSTP retreat! Great job all☺️
A view from @NINDSdirector , Dr. Walter Koroshetz, on the importance of the @BrainInitiative for understanding and treating brain disorders: BRAIN at 10: A View from the National Institute for Neurological Disorders and Stroke braininitiative.nih.gov/news-events/bl… #NINDS
Thrilled to share our latest research published in Nature Methods! We have developed improved green and red serotonin sensors for sensitive and dual-color monitoring of serotonin dynamics in vivo. Check out the full paper here: nature.com/articles/s4159…
Our review is out @NatureAging on models on neuronal senescence in aging and neurodegeneration, focusing particularly on human PSC-based approaches rdcu.be/dz2QR. This was an effort led by @IsabelleLuzy working with several other teams part of @ASAP_Research.
CRISPR gene therapy for the brain and spinal cord: What is it, why isn't it a reality yet and what needs to be done to bring it to the clinic. Check out our latest @JAMANeuro review article:jamanetwork.com/journals/jaman…