Nathan Moerke @NMoerke
Scientist in the SF Bay area currently working on gene therapies for neurological conditions. Previously @STEMCELLTech and @Denalitx, all opinions my own. San Francisco Bay Area, CA Joined May 2020-
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Excited to announce our scientists will present preclinical data for four programs from our vector engineering platform at the @ASGCTherapy 27th Annual Meeting in May. Read our news release: ow.ly/WJzl50Rosr2 #GeneTherapy #GeneTherapies #ASGCT2024
"Minicircle’s results are either wrong, or simply fake. I’d be overjoyed if they’re hitting the numbers they claim. It would be the equivalent of cold fusion for biology, made by two random sketchy dudes. We could stop spending hundreds of billions of dollars a year coaxing…
UCSF Parnassus has some of the nicest views in the city.
Commission for an epoxy piece to highlight SYNGAP1 protein localization in #neurons. Inspired by a cover from @SfNJournals (link in comments). Walnut, 19in tall. @cureSYNGAP1
Exciting new work from Nathanael Gray’s lab @Stanford_ChEMH published @ACSCentSci, covalent inhibitors with two electrophilic warheads subvert resistance due to single mutations in kinase targets pubs.acs.org/doi/10.1021/ac…
How humans lost their tails — and why the discovery took 2.5 years to publish. 🙏@ewencallaway nature.com/articles/d4158…
Encoded announces US IND clearance and Australian CTA approval for gene therapy candidate ETX101 for Dravet syndrome. Phase 1/2 clinical trials are planned to begin in the first half of 2024. More: ow.ly/JRUb50QypN1 #GeneTherapy #DravetSyndrome #ETX101 #ENDEAVOR #WAYFINDER
The first dog in our pivotal lifespan extension study STAY has been dosed - meet Boo the whippet! The study will be over 1,000 dogs, 55 clinical sites, about 4 years --> afaik, this is one of the largest animal health clinical trials ever run, even by the pharmas (!)
Some progress in developing non-opioid pain medications: fiercebiotech.com/biotech/vertex…
Promising new study on a blood test for phosphorylated tau as an Alzheimer's biomarker: jamanetwork.com/journals/jaman…
Today we report in @NatureBiotech a new device inspired by the Japanese art of kirigami that can continuously & non-invasively record electrical signals from 3D neural #organoids and #assembloids for long periods of time. Close collaborative work with @BianxiaoC under the…
Despite the pressure on life science valuations, Series A/B/C rounds still raised VC $ in 2023 at step-ups of 30-50% higher than prior rounds (1.3-1.5x at the median). Not as frothy as 2021, but remarkably strong for a "reset" year... #SVBHealthcare @SiliconVlyBank #biotech
2023 Small Molecule Approvals! @drughuntersite A lot of fascinating firsts in 2023 including: -The first FDA-approved oral ER degrader -The first FDA-approved reversible BTK inhibitor -The first FDA-approved gamma-secretase inhibitor (not in Alzheimer’s!) -A reversible…
Progress in reading, writing, and editing DNA has been relentless. With all of these new tools, why haven't we successfully cured every disease with a genetic basis? There are several reasons—including financing the cost of clinical development for rare diseases—but there is a…
New Year’s reading just arrived from Amazon:
🤖 A robotic time-saver for #bigscience – completed in less than 10 hours with minimal human interaction – our scientists developed an automated workflow for our human induced pluripotent stem (hiPS) cell culture procedures. Out now in @NatureProtocols nature.com/articles/s4159…
@ImmunologyAAI has officially launched #ImmunologyExplained, a campaign to help explain the science of the immune system so that everyone can make informed decisions about their immune health. Stay tuned for more content in the future! Visit immunologyexplained.org.
Interesting proposal to rejuvenate downtown SF by building a university campus, ideally a satellite for an existing world-class institution. Which university would be the best fit for a win-win? Take the poll or contribute a suggestion. sfchronicle.com/sf/article/dow…
Lennox-Gastaut syndrome (LGS) is a rare childhood-onset #epilepsy that is characterized by multiple seizure types. In honor of #LGSAwarenessDay, learn more about its defining characteristics and potential treatment options. #NEAM2023
Born deaf, this Chinese girl can hear again. A remarkable experiment takes gene therapy to a new frontier: restoring the senses. technologyreview.com/2023/10/27/108…
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CGM at MGH @CGM_MGH
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Zach Rosenthal @rosenthalzach1
204 Followers 499 Following Developing therapeutics for genetic forms of dementia https://t.co/p6SDGbMqC5 | Ph.D. @HarvardCCB, prev: @StanfordUChem
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A better crop and edit of the Brainard, NE tornado. One of the most photogenic landscapes I've ever captured a tornado over.
Sad to hear news that the Cancer Moonshot may be coming to an end due to budget cuts but it's unfortunately not surprising news given the current political environment. Another reason that cancer R&D at US companies is critical & shouldn't be discouraged by Congress
Congress is killing Biden's cancer moonshot politico.com/news/2024/04/2…
Just ran across this in my travels around the Interwebz. Seems like a fairly balanced take on AI drug discovery. Would like to have seen a bit more on what’s being done on the development and clinical side of things though. biopharmatrend.com/ai-drug-discov…
Entire Universe squeezed into a single image. (logarithmic scale)
Excited to announce our scientists will present preclinical data for four programs from our vector engineering platform at the @ASGCTherapy 27th Annual Meeting in May. Read our news release: ow.ly/WJzl50Rosr2 #GeneTherapy #GeneTherapies #ASGCT2024
an amazing third space designed for slow connection: 📍 People’s Park, Chengdu - 3 large tea pavilions overlooking the pond - free cards and board games - 100s of types of tea available on tap and food stalls of delicacies from varying regions - masseuses, ear cleaners, &…
Drought free California from space. What a sight.
This week, Air Canada launched its much-anticipated non-stop route between #Vancouver and #SINgapore. Flying 4x weekly as a permanent year-round service. Changi Airport is an attraction in its own right. #YVR #SIN #aviation dailyhive.com/vancouver/vanc…
Oracle Park just keeps being awesome
The notion that capitalism has failed rare diseases is incorrect. Yes, Pharma is too big to scale down. Yes, most rare diseases affect only a handful of patients. But that doesn’t mean developing medicines for rare diseases — even ultra-rare ones — can’t be profitable. In…
I've pulled together a list of biotech-themed questions that interest me in a new blog post. If they interest you too, get in touch!
It's been what, 10? 15 Years? Since journals have had some sort of minimum reporting standards for reagent use, yet here I am, after going through all five papers citing an antibody from a well known supplier and not a single one states the concentration used for western blotting
I visited BGI's headquarters in Shenzhen, China. The world's largest genome research company, with ~20,000 employees, they make DNA sequencers (increasingly nanopores) and synthesize DNA, too. This facility sequences 6,000 TB of genomic data per day.
More than 1 million people are dying each year from antibiotic resistance, considered a global health emergency. The pharma industry is doing little to respond. Thankfully academic labs, using A.I. and structure-based discovery, are kicking in. My summary Table of recent progress
Join us for a live webinar on April 3, hosted with @scientist_com, where speakers Danny Leung and Johnny Aether will describe what intestinal #organoids are, how they mimic the human gut epithelium, and how to use organoids for drug screening. 🧫
Commission for an epoxy piece to highlight SYNGAP1 protein localization in #neurons. Inspired by a cover from @SfNJournals (link in comments). Walnut, 19in tall. @cureSYNGAP1
This is incredibly important for academic folks starting to build in biotech. Cool technology without anyone to buy it usually leads to unsuccessful startups.
How to determine your market size - someone posted this….or can lookup your closest comp in public markets and check market cap. 🤷♂️
Every time someone asks me if the brain can recover from injuries, I will show the photos below! The brain is highly plastic and has tremendous recovery potential. Just check the photos below; there is only a 5-day difference between them! A team at Mass General Brigham treated…
Orchard's therapy for neuron disease in children wins FDA approval statnews.com/2024/03/18/met…
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