Keith Robison @OmicsOmicsBlog
Computational biologist in drug discovery since '96. omicsomics.blogspot.com Boston, MA Joined February 2010-
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Keith Robison retweeted
GW: ultra-fast chromosome-scale visualisation of genomics data biorxiv.org/content/10.110…
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Keith Robison retweeted
30 years ago, we managed the screwworm issue (one of the more visually disgusting pests that infects cows and can really mess with our dairy and beef supply chains) in a clever but low-tech way (airdropping in sterile male screwworms to slowly eradicate the population since…
30 years ago, we managed the screwworm issue (one of the more visually disgusting pests that infects cows and can really mess with our dairy and beef supply chains) in a clever but low-tech way (airdropping in sterile male screwworms to slowly eradicate the population since…
Keith Robison retweeted
One reason I am (and people should) be suspicious of knock-outs at replicating the effects of what small molecule or mAb inhibitors will do.
Keith Robison retweeted
Had a nice visit to San Francisco this week, and I actually got to meet @jbloom_lab in person. Nothing happened while I was gone did it? gladstone.org/events/viral-l…
Keith Robison retweeted
Soviet war correspondents, in danger of being shot for "defeatism" if they send back negative news, are now reporting: "much-battered Germans continue their cowardly advance."
Keith Robison retweeted
National security tariffs on bathroom vanities
National security tariffs on bathroom vanities
Keith Robison retweeted
My new favorite justification for studying the genetics behind prolificacy (how many ears an individual corn plant produces)....
Keith Robison retweeted
Protein tandem repeats that produce frameshifts can generate new structural states and functions "frameshifts, especially with short repeats, lead to a significant increase in hydrophobicity and arginine content." febs.onlinelibrary.wiley.com/doi/10.1111/fe…
Keith Robison retweeted
Thrilled to share that today we report our human protein interactome in @ScienceMagazine! Predicting which pairs of proteins in the human proteome is a great challenge due to the shallow eukaryotic evolutionary signals but hugely important to understand. science.org/doi/10.1126/sc…
Keith Robison retweeted
Large association study of creatine kinase levels (marker of muscle damage) across several large biobanks Made me wonder if there are large sequencing studies of exercise intolerance more generally -- doesn't seem like it medrxiv.org/content/10.110…
Keith Robison retweeted
🚨 New preprint out! We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation. This reveals intensified assortment in recent generations. 🔗biorxiv.org/content/10.110…
Keith Robison retweeted
Predicting protein-protein interactions in the human proteome | Science science.org/doi/10.1126/sc…
Keith Robison retweeted
In case you are not yet clear on how this usually goes, any critic, opposition group, protesters, or anyone else they target will be declared extremist or antifa or left wing terrorist. Laws will be passed on extremist speech and actions. Emergency powers invoked otherwise.
In case you are not yet clear on how this usually goes, any critic, opposition group, protesters, or anyone else they target will be declared extremist or antifa or left wing terrorist. Laws will be passed on extremist speech and actions. Emergency powers invoked otherwise.
Keith Robison retweeted
Former national park superintendents urge Trump administration to close parks in case of shutdown trib.al/nIOVoIb
Keith Robison retweeted
CLAE: A High-Fidelity Nanopore Sequencing Strategy for Read-Level Viral Variant Detection and Environmental RNA Virus Discovery. #nanopore #SNP #SV doi.org/10.1002/advs.2…
Keith Robison retweeted
🔥 What if DNA synthesis was the generative model? 🧬 Variational Synthesis turns stochastic chemistry into the sampler: 10^16–10^17 molecules, ~$10^3 cost, ~97% accuracy From 325M Abs to petascale libraries of Abs, HLA epitopes & polymerases. Is the bottleneck now synthesis…
Keith Robison retweeted
ADCs are not just “guided missiles” — new biology is reshaping how we view them 🌊 Continuous payload exposure in circulation sustains cytotoxic thresholds 🔀 Antigen level ≠ response: extracellular cleavage enables efficacy in “HER2-null” tumors 🛡️ Fc functions &…
Keith Robison retweeted
There’s another catch: many models struggle outside the hospital they were trained in. In 2024, 38% of FDA-cleared radiology AIs were tested on data from just one hospital. Move them elsewhere, and accuracy can drop by up to 20 percentage points.
Keith Robison retweeted
Earlier this year, the President’s budget proposed a 40% cut to the NIH budget. This sparked an obvious research question: What if the NIH had been 40% smaller in previous years? Here’s what Pierre Azoulay, Danielle Li, Bhaven Sampat, and I found when we looked at grants that…
Keith Robison retweeted
Doing my favorite thing: buying a bunch of used books from a store and repairing to a coffee shop to browse them.
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