Ethan Iverson @TheEthanIverson
Unrepentantly obsessed with influenza virus. Interested in virus-host interactions, virus pleomorphy, airway epithelium and immune history. Not an immunologist. Joined April 2012-
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“The next flu pandemic—whether caused by an avian influenza A(H5N1) virus or otherwise—seems inevitable.” #vogelgriep thelancet.com/journals/lanin…
I’m excited to discuss our latest research on how ambient CO2 affects how long #SARSCoV2 remains infectious in air. We report that even subtle increases in CO2 affects both how long #COVIDisAirborne and transmission risk. Here’s a🧵going over the findings nature.com/articles/s4146…
With identification of PB2-M631L, PA-K497R, PA-E613K in cattle lineage... there is a timely preprint from @wendybarclay11 and Grimes labs with a CryoEM structure of #H5N1 (A/turkey/Turkey/1/2005) FluPolA polymerase complex with human ANP32B. researchsquare.com/article/rs-371…
With identification of PB2-M631L, PA-K497R, PA-E613K in cattle lineage... there is a timely preprint from @wendybarclay11 and Grimes labs with a CryoEM structure of #H5N1 (A/turkey/Turkey/1/2005) FluPolA polymerase complex with human ANP32B. researchsquare.com/article/rs-371…
The human case in Texas still clusters outgrouped to the entire cattle cluster, indicating that they were likely infected prior to the sampled infection from the cattle represented in this tree. This is true across the entire genome.
Our latest preprint (not peer reviewed yet). Influenza's M2 proton channel is cleaved by caspases to remove the LIR motif. We solve co-crystal structure of M2 and LC3 to show it's not overlapping with cleavage site. Great collaboration with @avi_cmbi. biorxiv.org/content/10.110…
So, *preliminary* molecular clock analyses indicate that the time of the most recent common ancestor (TMRCA) of the US cattle flu clade was late December. TMRCA of that clade and the closest relatives in birds, mid-December. If single intro, likely between those rough dates.
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
My understanding is that these bird (and cat) viruses within the "bovine" clade were sampled from farms that had bovine H5N1. So, are the birds on these farms giving this virus to the cattle, or are the cattle giving it to the birds? It is cattle to birds very likely.
Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an ... biorxiv.org/cgi/content/sh… #biorxiv_molbio
Great work from @MichaelWorobey @xrayfoo , et al. to generate consensus sequences from the USDA raw sequence data released by the USDA. Lots more analysis is needed, as well as information on cattle movement but sequences seem consistent with a single source introduction
Great work from @MichaelWorobey @xrayfoo , et al. to generate consensus sequences from the USDA raw sequence data released by the USDA. Lots more analysis is needed, as well as information on cattle movement but sequences seem consistent with a single source introduction
Another good perspective on the current, spreading outbreak of highly pathogenic avian influenza H5N1 virus in the food supply. Great points by @mtosterholm @michaelmina_lab @andrewpekosz by @lisamjarvis in @Bloomberg @business bloomberg.com/opinion/articl…
U.S. government in hot seat for response to growing cow flu outbreak science.org/content/articl…
As I've been writing this on typefully, I've just learned that 249 genome ssequences have finally been released. I am going to hop off here and start have a look now. But thing I can guarantee is that if these genomes had been released in real time...
@PeacockFlu I find it interesting because the Texas cow PB2 seqs in GISAID are E627 I believe while the human case associated with that cluster is K627. I may be wrong but that's what I recall. It would be weird if the mutation doesn't come up in the cows but than swiftly in a human.
It's been getting on for a year since I wrote this thread - heres a bit of an update of where we are with the evidence for mammal-to-mammal transmission of H5N1s. x.com/peacockflu/sta…
It's been getting on for a year since I wrote this thread - heres a bit of an update of where we are with the evidence for mammal-to-mammal transmission of H5N1s. x.com/peacockflu/sta…
Excited to share our @NatImmunol News & Views discussing this 👇 @NatureMicrobiol paper on aging of nose epithelial cells, #IFNs, & #COVID19 in light of the works of @virusninja @casanova_lab @BrodinPetter @ordovas_phd @CBLopezLab @DavidLRobrtson et al!👉 rdcu.be/dFb9A
Excited to share our @NatImmunol News & Views discussing this 👇 @NatureMicrobiol paper on aging of nose epithelial cells, #IFNs, & #COVID19 in light of the works of @virusninja @casanova_lab @BrodinPetter @ordovas_phd @CBLopezLab @DavidLRobrtson et al!👉 rdcu.be/dFb9A
What connects two regions on opposite ends of NSP12, a narrow slice of an obscure NSP3 region (DPUP/SUD-C), & a 3-AA sliver of nucleocapsid (N)? I have no idea, but I’m convinced there’s a link that could help reveal the inner workings of SARS-CoV-2. 1/120
Pre-print with some genomic data for H5N1 in dairy cattle and cats. Shows how H5N1 keeps evolving...not great. Also shows that this strain has some but not many important mammalian adaptation markers...so far, so good. Still need more epi data. wormsandgermsblog.com/2024/04/articl…
The origins of RNA viruses can be hard to trace. This #ReviewedPreprint considers a more recent origin for coronaviruses and suggests their diversification occurred mainly through host switching rather than diversification with hosts. elifesciences.org/reviewed-prepr…
Lots of fair questions in this article. I do not envy the heavy task of the USDA and supporting labs and researchers, but there has to be more information sharing to the best of their ability. #influenza #H5N1 statnews.com/2024/04/18/h5n…
Stuart Neil @stuartjdneil
16K Followers 1K Following Virologist. 🦠 HIV, EBOV, SARS2 and Flu interactions with their hosts. ‘Biodefense expert’ according to a hack
Dr. Angela Rasmussen @angie_rasmussen
453K Followers 8K Following Virologist. PI @VIDOInterVac. Adj Prof @USask BMI. P2 @covarr_net. Jeopardy! loser. Famed for my obnoxious turns of phrase. 🇺🇸in🇨🇦. she/her
Sam Gregson @Samuel_Gregson
3K Followers 2K Following Uni of Cambridge and LHC physicist (Graduated) Science communicator and YouTuber The Bad Boy of Science Linktree: https://t.co/e41vofiBDZ
Edward Nirenberg 🇺.. @ENirenberg
36K Followers 6K Following Views my own, but you can borrow them if you feel so inclined. Anti-disease. Big Nerd Energy. “A homework person.” Fun at parties. Antibody hoarder. he/him
Jasnah Kholin - 8964 .. @wanderer_jasnah
10K Followers 1K Following HKer. RNA Virologist working on nidovirus/immune system interactions. Insomniac. Life before death. Journey before destination. 一个健康的社會不該只有一種聲音. 解散警隊. ★ she/佢 ★
Philipp Markolin, PhD @PhilippMarkolin
4K Followers 770 Following Science blogger and communicator. Not a fan of myth, manipulation and magical thinking in the information age. Also: https://t.co/KKLHqGzMxC
Peter Jacobs @past_is_future
5K Followers 5K Following researching Pliocene and future climate and hoping to keep the former from becoming the latter.
Jeremy Kamil is also .. @macroliter
25K Followers 5K Following He, him. CMV virologist exploring how viruses exploit glycoimmune checkpoints #Glycotime | Loves 🥾 🏔️ 🏕️| Y'all on Bluesky or Threads? Linktree below ⬇️
Peter Daszak @PeterDaszak
32K Followers 549 Following @EcoHealthNYC President. @theNASEM Forum on #microbialthreats Chair. Zoologist. Parasitologist. Ecologist. British. American. Ukrainian. 🇬🇧🇺🇦🇺🇸
Tom Peacock @PeacockFlu
51K Followers 1K Following Virologist. Viruses, Influenza, Coronaviruses and SARS-CoV-2. Typos are intenitonal. Fellow at @Pirbright_Inst and @ImperialInfect
Zach Hensel @alchemytoday
2K Followers 937 Following No longer active on this site. Send an email to connect.
Michael Worobey @MichaelWorobey
13K Followers 262 Following Viruses. Pandemics. Professor and Head of Ecology and Evolutionary Biology at the University of Arizona. Tweets mine.
everythingism @_everythingism
776 Followers 5K Following
Hutchinson Lab @CVRHutchinson
8K Followers 6K Following Molecular virology lab @CVRinfo @UofGlasgow @The_MRC | Social media influenza | Group account | Posts often, but not always, from Ed Hutchinson (he/his)
Moreno Colaiacovo @emmecola
4K Followers 1K Following Bioinformatics l Web development | Data analysis - I work as an external consultant for the JRC. All views expressed are my own.
Nic ( children of the.. @nicolascgrey
1K Followers 3K Following one day we will all be dead 🐲 Takiwātanga my/his/her own time and space”.
Greg Tucker-Kellogg @gtuckerkellogg
3K Followers 2K Following Dad scientist. Biology prof in Singapore post biotech industry career. Musician on the side. Occasional tweets in Chinese. (he/him)
VignuzziLab @VignuzziLab
16K Followers 9K Following viruses-evolution-Singapore-fitness! @idlabs_astar. #PrideInSTEM 🏳️🌈 #DiversityInSTEM 🇸🇬🇮🇹🇨🇦🇫🇷🇺🇸🇸🇦🇬🇧🇭🇺🇲🇾
Zhihua Chen @zhihuachen
1K Followers 1K Following Florida man. Bioinformatician. Data scientist. News junkie. Bridge/tunnel. Human/Chinese/American/Mainland/Southern/Fudiunin/Asian/华人/大陆人/中国人/美国人. 陈 陳 Chen Tin
Dr CJ Houldcroft 🕷.. @DrCJ_Houldcroft
7K Followers 990 Following Lecturer working on virus evolution, from a scale of weeks (within a single patient) to millennia (between humans and Neanderthals). #GirlySwot
Lee Altenberg, Ph.D. @AltenbergLee
4K Followers 4K Following Theoretical biologist researching evolution. Information & Computer Sciences/Mathematics/Ecology Evolution & Conservation Biology, U Hawai`i@Mānoa Herr/Prof/Dr
Deb 🖕🏼🦠 @Violet_Kitteee
727 Followers 1K Following STOP SPREADING COVID 🦠☠️🦠 #CovidIsAirborne #WearARespirator #WearN95
PandemicWatch @PandemicWatch2
24 Followers 29 Following
hubbub @HubbubWorld
2K Followers 771 Following Check your personal COVID-19 risk: https://t.co/ID0nfjVdM7 🦣 https://t.co/XjLFcP5frK 🧵@[email protected]
a @abdulsul
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Mojorabbit @mojorabbit
3K Followers 5K Following retired RN, wildlife rehabber, beekeeper, music lover, politically curious #resist #workingthemojo
Lindsay Bosten @LindsBoste
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Roma Noriega @ro_norie
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Frankie Oreb @FrankieOre64179
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Marc Veldhoen @Marc_Veld
15K Followers 1K Following Head of Lab, Professor Basic Immunology, T cell expert. Mass blocks reinitiated on abusive accounts and those spreading disinformation.
BlaBelle @bruce_labelle
78 Followers 2K Following Organic chemist; Environmental Chemistry Lab Director; lover of science and the natural world; ultrarunner; enjoy learning new things in fields far from my own
Ala🌟🐱 @lollyyy66524
1K Followers 2K Following I just do my own, I do not care about other people.🌸🌸 Youth is not a time of life, it is a state of mind.🌸🌸
Sydney Mcrea @SydnMcre
63 Followers 5K Following
Chlanda lab @ChlandaL
1K Followers 525 Following Membrane Biology of Viral Infection cryo-ET, cryo-CLEM, cryo-FIB, influenza, Ebola virus, SARS-CoV-2
Zana Kennel @za_kenn
31 Followers 5K Following
Tonja Authement @AuthemeTon
68 Followers 5K Following
Amna Simler @AmnaSiml
70 Followers 5K Following
Euan Arnott @Nucleocapsoid
154 Followers 111 Following
Moose @Moose994154
0 Followers 200 Following
Kaylee Petraccione @kaypepperoni
250 Followers 565 Following Biomedical and Veterinary Sciences PhD Candidate at Virginia Tech | Rift Valley fever virus enthusiast #virology #autophagy
Adah Duffin @duffin12492
48 Followers 5K Following
Janie 🍓 @Janie3143
6 Followers 537 Following Аntiсiраte bеcoming hеlplesslу drawn tо mу intоxiсating charm
George_Moschonas @MoschonasG
130 Followers 332 Following PhD student @UGent and @VIBLifeSciences. Viruses 🦠 , Proteomics , and innate immunity.
Caroline Goujon, PhD @caro_goujon
3K Followers 1K Following Virologist (INSERM) and PI, IRIM, CNRS, Montpellier university. Views my own. #FirstGen. https://t.co/rgds3mdcTD, @caro.goujon.bsky.social
Fancy Pants, all of y.. @YouseFancyPants
188 Followers 914 Following
Marie @marie_ford_
196 Followers 3K Following
Ellah Ascensio @EllAscens
25 Followers 5K Following
Darcy Chappel @ChappeDar
37 Followers 5K Following
Wayne Westerman, PhD @mrlighttouch
947 Followers 3K Following STEM Dad, Dancer, Fence Builder, Wind Surfer.
Nat Moss 💚 @NatMoss
16K Followers 18K Following Conservation writer/editor; producer, @WCSWildAudio podcast; proud husband and dad; transplanted Texan; follow & tweet esp environment, film & political news.
auntie cistamine @laurenancona
30K Followers 17K Following neurodivergent public servant • learning to help • 338ppm • she • no DMs
Phillip Kyriakakis @breakliquid
7K Followers 6K Following Senior Research Scientist at Stanford Bioengineering | Taking apart and building biology.
AJ te Velthuis @aj_velthuis
1K Followers 629 Following Assistant professor @Princeton University #influenza #coronavirus #RNA polymerase. Funding NIH & Wellcome Trust
Dr. Max Maurer @MaxMaur31990342
35 Followers 461 Following
A Devoted Yogi @ADevotedYogi
355K Followers 181K Following Life Enthusiast, Alchemist, Functional Nutrition, Longevity. Observations, a Commentary on Current Events. Amplifier, Reposts. I chose Humanity. Cancel CableTV
Carol Sheppard @Dr_Shepp
146 Followers 197 Following Molecular virologist with a passion for polymerases. Advocator for equality and environmental sustainability and anything that can be done from a hammock.
Xander de Haan @HaanXander
713 Followers 429 Following Associate prof. (C.A.M. de Haan) of molecular influenza virology @UtrechtVirology. Also working on paramyxoviruses and elephant endotheliotropic herpesvirus.
Marco Del Riccio @MarcoDelRiccio
414 Followers 1K Following Medico | MD Specialista in Igiene e Medicina Preventiva | #PublicHealth| All views are my own, RT are not endorsements
Patrick Bohn @PatrickBohnPB
177 Followers 522 Following mostly interested in RNA (viruses) and Nanopores and 3d printing -currently PhD Student
Covid Safe Network @covidsafenetwrk
8K Followers 3K Following I’m sorry if the virus outlasted your capacity for empathy. And if it didn’t, thank you. Covid is not over.
Stuart Neil @stuartjdneil
16K Followers 1K Following Virologist. 🦠 HIV, EBOV, SARS2 and Flu interactions with their hosts. ‘Biodefense expert’ according to a hack
Dr. Angela Rasmussen @angie_rasmussen
453K Followers 8K Following Virologist. PI @VIDOInterVac. Adj Prof @USask BMI. P2 @covarr_net. Jeopardy! loser. Famed for my obnoxious turns of phrase. 🇺🇸in🇨🇦. she/her
Sam Gregson @Samuel_Gregson
3K Followers 2K Following Uni of Cambridge and LHC physicist (Graduated) Science communicator and YouTuber The Bad Boy of Science Linktree: https://t.co/e41vofiBDZ
Edward Nirenberg 🇺.. @ENirenberg
36K Followers 6K Following Views my own, but you can borrow them if you feel so inclined. Anti-disease. Big Nerd Energy. “A homework person.” Fun at parties. Antibody hoarder. he/him
Jasnah Kholin - 8964 .. @wanderer_jasnah
10K Followers 1K Following HKer. RNA Virologist working on nidovirus/immune system interactions. Insomniac. Life before death. Journey before destination. 一个健康的社會不該只有一種聲音. 解散警隊. ★ she/佢 ★
Flo Débarre @flodebarre
10K Followers 2K Following @[email protected] @flodebarre.bsky.social • CNRS senior researcher, Theoretician in Evolutionary Biology • Own views • EN & FR
Philipp Markolin, PhD @PhilippMarkolin
4K Followers 770 Following Science blogger and communicator. Not a fan of myth, manipulation and magical thinking in the information age. Also: https://t.co/KKLHqGzMxC
Florian Krammer @florian_krammer
338K Followers 1K Following Viruses, viruses, viruses and vaccines. V5=3xancestral+1x bivalent+1xXBB Professor at the Department of Microbiology Icahn School of Medicine at Mount Sinai
Health Nerd @GidMK
81K Followers 2K Following https://t.co/hkLzdpoOQd Epidemiologist. Writer (Slate, TIME, etc). ' Research fellow at @UoW Host of @senscipod Email [email protected] he/him
Peter Jacobs @past_is_future
5K Followers 5K Following researching Pliocene and future climate and hoping to keep the former from becoming the latter.
Jeremy Kamil is also .. @macroliter
25K Followers 5K Following He, him. CMV virologist exploring how viruses exploit glycoimmune checkpoints #Glycotime | Loves 🥾 🏔️ 🏕️| Y'all on Bluesky or Threads? Linktree below ⬇️
Peter Daszak @PeterDaszak
32K Followers 549 Following @EcoHealthNYC President. @theNASEM Forum on #microbialthreats Chair. Zoologist. Parasitologist. Ecologist. British. American. Ukrainian. 🇬🇧🇺🇦🇺🇸
Aris Katzourakis @ArisKatzourakis
37K Followers 2K Following Paleovirology, cross-species transmissions, evolution, genomics, viruses, selfish genes. UCU NEC, Branch Hon Sec, Oxford Biol. Tweets mine, retweets not.
Tom Peacock @PeacockFlu
51K Followers 1K Following Virologist. Viruses, Influenza, Coronaviruses and SARS-CoV-2. Typos are intenitonal. Fellow at @Pirbright_Inst and @ImperialInfect
Marion Koopmans, publ.. @MarionKoopmans
86K Followers 3K Following https://t.co/x3zIbMPDg5 Head of Viroscience Department , WHO collaborating centre EID
Zach Hensel @alchemytoday
2K Followers 937 Following No longer active on this site. Send an email to connect.
Stephen Goldstein @stgoldst
8K Followers 2K Following Evolutionary virology postdoc @ Univ of Utah. Previously Penn Medicine. Coronaviruses and the Wasatch.
Ryan Hisner @LongDesertTrain
22K Followers 838 Following Teacher "Be ruthless with systems and be kind to people." Michael Brooks, 1983-2020
Prof Gavin Yamey @gav.. @GYamey
41K Followers 8K Following Professor of Global Health & Public Policy @DukeU. Director, Center for Policy Impact in Global Health. DJ @wxdu. TIME columnist. He/him. Tallest Jew on Earth.
Michael Worobey @MichaelWorobey
13K Followers 262 Following Viruses. Pandemics. Professor and Head of Ecology and Evolutionary Biology at the University of Arizona. Tweets mine.
Louise Moncla @LouiseHMoncla
2K Followers 295 Following Assistant Professor of Pathobiology @pennvet using trees to study RNA virus evolution and transmission. viruses, sequencing, phylogenetics, pop gen. She/her
JusDayDa @JusDayDa
3K Followers 1K Following Justice through Data - ApplePai - School Classrooms with Fresh Air=Education no longer Impaired
Martha Nelson @swientist
260 Followers 196 Following Evolutionary biologist, distance runner, semi-competent mom.
STAT @statnews
165K Followers 5K Following Reporting from the frontiers of health & medicine. Sign up for any of our 10 free newsletters here: https://t.co/CBx3GZBv31
Lisa Schnirring @lisaschnirring
2K Followers 744 Following Science Writer, Center for Infectious Disease Research and Policy (CIDRAP)
Michael Coston @Fla_Medic
5K Followers 531 Following Retired EMT-II, Blogging on Emerging Infectious Diseases, Pandemic Influenza, and Personal and Community Preparedness
Michael T Wolfinger @mtwolfinger
1K Followers 1K Following RNAForecast CEO // Visiting Professor // RNA enthusiast with a passion for structure, dynamics, viruses, and evolution 🧬🦠
RNAStructureBot @RNAStructureBot
377 Followers 20 Following RNA Structure bot retweeting #RNAStructure & #StructuralRNA Pubmed articles and #bioRxiv #arXiv preprints. Semi-curated by @RhysHParry
Jeffrey Kieft @JeffreyKieft
3K Followers 729 Following Executive Director, NYSBC (@NYSBC_Science); RNA biochemist, biophysicist, structural biologist, and virologist. Go Army, Beat Navy! pronouns: he/him/his
Jake Sherman @JakeSherman
438K Followers 4K Following Founder of @punchbowlnews. @nbcnews/@msnbc. Phish/Dead fan. Author of NYT best seller, “The Hill To Die On”.
Marc Veldhoen @Marc_Veld
15K Followers 1K Following Head of Lab, Professor Basic Immunology, T cell expert. Mass blocks reinitiated on abusive accounts and those spreading disinformation.
good papers @paperperday
3K Followers 561 Following micropapers (less circulated): biological engineering/synbio, host-microbe/microbe-microbe interactions, environmental science & evolution
Dept. of Agriculture @USDA
990K Followers 3K Following Leadership on #food, #agriculture, natural resources, #rural development, #nutrition, & related issues based on public policy, science, & effective management.
Mason Hamilton🛢�.. @T_Mason_H
12K Followers 2K Following VP of Econ & Research @APIenergy. Coming up with 61.8% good ideas, 38.2% bad. Energy analyst, meme enthusiast. Ex-EIA, DOE, IEF. Have a nice day. Tweets my own!
Robertson @robertson_lab
4K Followers 2K Following Computational virology research group exploring virus evolution, virus-host interactions & disease, in @CVRbioinfo, part of @CVRinfo. Tweets by @DavidLRobrtson.
Ian Ellis @ianellisjones
32K Followers 987 Following Founder ✈︎ IEJ Media ⚡︎ I write about & try to make sense of what matters most ⚡︎ Puncturing false narratives of adversaries ⚡︎ ex @goldmansachs ⚡︎ Newsletter ⇩
Caroline Goujon, PhD @caro_goujon
3K Followers 1K Following Virologist (INSERM) and PI, IRIM, CNRS, Montpellier university. Views my own. #FirstGen. https://t.co/rgds3mdcTD, @caro.goujon.bsky.social
George_Moschonas @MoschonasG
130 Followers 332 Following PhD student @UGent and @VIBLifeSciences. Viruses 🦠 , Proteomics , and innate immunity.
Peter Miller @tgof137
1K Followers 240 Following
Nat Moss 💚 @NatMoss
16K Followers 18K Following Conservation writer/editor; producer, @WCSWildAudio podcast; proud husband and dad; transplanted Texan; follow & tweet esp environment, film & political news.
Guardian Environment @guardianeco
518K Followers 7K Following News and comment on the world's most important environmental stories
U.S. Central Command @CENTCOM
689K Followers 1K Following Official Account of U.S. Central Command (CENTCOM).
Alison Feder @AlisonFeder
2K Followers 939 Following Assistant Prof @uwgenome. Evolutionary dynamics in viruses and cancer. she/her @[email protected]
Daniel Goldhill @influenzal
932 Followers 1K Following Scientist. Lecturer in Virology @RoyalVetCollege. Likes experimental evolution, influenza and coronaviruses. Main life goal: never running a western blot.
Abhay Kotecha @AbhayKot
2K Followers 552 Following Structure Biologist, CryoEM expert, Atomic blobologist; DPhil @OxfordUni, scientist @ThermoFisher. also on Mastodon @[email protected]
Tristan Croll @CrollTristan
4K Followers 479 Following Principal Scientist at Altos Labs. Making data-based macromolecular modelling faster, more accurate and a bit more fun. Devoted husband and father.
Jonathan Brown @joncbrown90
78 Followers 37 Following
John Briggs @BriggsGroup
5K Followers 167 Following Briggs group at MPI Biochemistry. Cryo-EM, tomography, subtomogram averaging, CLEM, coated vesicles, enveloped viruses.
Phillip Kyriakakis @breakliquid
7K Followers 6K Following Senior Research Scientist at Stanford Bioengineering | Taking apart and building biology.
Amanda Zihan Zhu @AmandaZihanZhu
356 Followers 288 Following Proud to be called a Virologist. Fodorian. Dunn schooler. I do bench work to procrastinate… 🦠🧪🧫👩🏻🔬
AJ te Velthuis @aj_velthuis
1K Followers 629 Following Assistant professor @Princeton University #influenza #coronavirus #RNA polymerase. Funding NIH & Wellcome Trust
Philippe Le Mercier, .. @ViralZone
1K Followers 120 Following
Dr. Stephanie Avery-G.. @saverygo
3K Followers 2K Following Research scientist w @ECCCSciTech | #seabirds #cumulativeeffects #decisionscience #HPAI #scicomm | I speak for myself. she/her
Falklands Wildlife He.. @FIWildHealth
104 Followers 39 Following We study infectious disease in the wildlife of the Falkland Islands Feat. @CornellVet, @SAERI_FI, @FI_Conservation and collaborators, and support from @UKBCFs
FCPS-MD @FCPSMaryland
48K Followers 1K Following Official source for Frederick County Public Schools news. We support every child, every day.
Frederick County @FredCoGovMD
18K Followers 167 Following The official account for Frederick County Maryland Government. Stay connected with us on Facebook and Instagram #RichHistoryBrightFuture
Frederick News-Post @frednewspost
46K Followers 943 Following Frederick County's leading source for news, sports, arts, entertainment and commentary.
Marlene K Wolfe @MarleneKWolfe
1K Followers 439 Following Environmental Health Engineer | Environmental Microbiology and Pathogens | Asst Professor @EmoryRollins @EmoryCGSW
Adrienne Watson @NSC_Spox
57K Followers 42 Following Official account of the White House National Security Council Spokesperson, serving under the leadership of National Security Advisor @JakeSullivan46.
Black Bird Group @Black_BirdGroup
23K Followers 12 Following OSINT group based in Finland. Currently focused on following and analyzing the Russian invasion of Ukraine.
Helen Branswell 🇨�.. @HelenBranswell
221K Followers 2K Following I cover infectious diseases @statnews. 2020 Polk winner. Nieman '11. She/her. #H5N2 #birdflu #Covid #polio #flu, #RSV. I have not paid for a blue checkmark.
Carol Sheppard @Dr_Shepp
146 Followers 197 Following Molecular virologist with a passion for polymerases. Advocator for equality and environmental sustainability and anything that can be done from a hammock.
Charles Lister @Charles_Lister
164K Followers 2K Following Senior Fellow & Director of @MEI_Syria & @MEI_CTE programs at @MiddleEastInst. Sanctioned by Russia, PNG’d by Syria & Iran, & wanted by ISIS & AQ.
MT Anderson @MT_Anderson
17K Followers 465 Following 🇺🇸 husband, girl dad, son, brother 🇺🇸 ••• ⚽️ 🚵 ⛷ 🏔 ••• ••• Opinions are my own •••
The Drew Weissman Lab @WeissmanLab
9K Followers 222 Following Bringing mRNA therapeutics to the world.
Katalin Kariko @kkariko
70K Followers 262 Following I am a scientist, working on the therapeutic use of in vitro transcribed mRNA.
John Paget, PhD @PagetPhd
865 Followers 259 Following Senior Scientist (Epidemiology) in the field of influenza, RSV and SARS-CoV-2. Co-Chair Global Influenza Initiative. Views private and own
Xander de Haan @HaanXander
713 Followers 429 Following Associate prof. (C.A.M. de Haan) of molecular influenza virology @UtrechtVirology. Also working on paramyxoviruses and elephant endotheliotropic herpesvirus.“The next flu pandemic—whether caused by an avian influenza A(H5N1) virus or otherwise—seems inevitable.” #vogelgriep thelancet.com/journals/lanin…
I’m excited to discuss our latest research on how ambient CO2 affects how long #SARSCoV2 remains infectious in air. We report that even subtle increases in CO2 affects both how long #COVIDisAirborne and transmission risk. Here’s a🧵going over the findings nature.com/articles/s4146…
With identification of PB2-M631L, PA-K497R, PA-E613K in cattle lineage... there is a timely preprint from @wendybarclay11 and Grimes labs with a CryoEM structure of #H5N1 (A/turkey/Turkey/1/2005) FluPolA polymerase complex with human ANP32B. researchsquare.com/article/rs-371…
One big question has been whether these cattle viruses carry known, mammal-adaptive mutations. None of the cattle sequences have PB2 E627K, but all have M631L, an alternative, putative adaptive mutation. nextstrain.org/avian-flu/h5n1…
The human case in Texas still clusters outgrouped to the entire cattle cluster, indicating that they were likely infected prior to the sampled infection from the cattle represented in this tree. This is true across the entire genome.
Our latest preprint (not peer reviewed yet). Influenza's M2 proton channel is cleaved by caspases to remove the LIR motif. We solve co-crystal structure of M2 and LC3 to show it's not overlapping with cleavage site. Great collaboration with @avi_cmbi. biorxiv.org/content/10.110…
So, *preliminary* molecular clock analyses indicate that the time of the most recent common ancestor (TMRCA) of the US cattle flu clade was late December. TMRCA of that clade and the closest relatives in birds, mid-December. If single intro, likely between those rough dates.
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
My understanding is that these bird (and cat) viruses within the "bovine" clade were sampled from farms that had bovine H5N1. So, are the birds on these farms giving this virus to the cattle, or are the cattle giving it to the birds? It is cattle to birds very likely.
Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an ... biorxiv.org/cgi/content/sh… #biorxiv_molbio
@TheEthanIverson @BrianRWasik Even if this is so. We are coming on 2 months..
Great work from @MichaelWorobey @xrayfoo , et al. to generate consensus sequences from the USDA raw sequence data released by the USDA. Lots more analysis is needed, as well as information on cattle movement but sequences seem consistent with a single source introduction
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
Another good perspective on the current, spreading outbreak of highly pathogenic avian influenza H5N1 virus in the food supply. Great points by @mtosterholm @michaelmina_lab @andrewpekosz by @lisamjarvis in @Bloomberg @business bloomberg.com/opinion/articl…
U.S. government in hot seat for response to growing cow flu outbreak science.org/content/articl…
Yeah, this is where we are at. I'm too tired to play games. I just want to see the data. I'm just assuming there will be a more formal report. And I'll post it here. All the rest is a waste of my bandwidth atm. #H5N1 x.com/helenbranswell…
@TheEthanIverson No, just WGS data as far as I can tell
@TheEthanIverson @MichaelWorobey x.com/usda_aphis/sta…
(2/2) ...and the recent H5N1 event in dairy cattle to encourage more disease research. More here: aphis.usda.gov/livestock-poul…
As I've been writing this on typefully, I've just learned that 249 genome ssequences have finally been released. I am going to hop off here and start have a look now. But thing I can guarantee is that if these genomes had been released in real time...
I totally get what Michael is saying - but I think we need to imagine a new strategy in this situation. Swabbing and testing farm works individually is just not gonna work. These people are overwhelmingly going to be migrant and undocumented workers that will refuse.
Surveillance for a potential zoonotic jump of bird flu using ER visits as a main source of data seems like a “little too late” strategy How about… I don’t know, asking the people on the farms where outbreaks have been detected to provide swabs on a routine basis. That would be…
We may have to think of some type of population level testing of human exposure cases (eg waste, environmental sampling) or a robust non-ID strategy that gets at the virus identification and dynamics in absence of any specific individual human host.
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