Adrian Isaacs Lab @adrianisaacslab
https://t.co/x1yYnHFij1 London laboratory investigating disease mechanisms of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia London, England Joined January 2017-
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Go Yash!! @yashgx
Adrian Isaacs Lab retweeted
Our open access opinion in @Brain1878 on the disappointing C9 ASO trials and next steps to deliver an effective treatment for C9ALS/FTD co-written with @AlexCammack @RubikaBalendra @UKDRI @UCLIoN academic.oup.com/brain/article/…
Adrian Isaacs Lab retweeted
Delighted to see our study led by @milioto_carmelo revealing a neuroprotective ECM signature in C9FTD/ALS published! Thanks to @mndassoc @UKDRI and many others! nature.com/articles/s4159…
Adrian Isaacs Lab retweeted
After failure of ASO trials targeting C9orf72 sense repeats also targeting antisense repeats is now vital. Our new preprint shows a potential approach using CRISPR-CasRx @UKDRI @UCLIoN @AlexCammack biorxiv.org/content/10.110…
Adrian Isaacs Lab retweeted
Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/sh… 1/9
Adrian Isaacs Lab retweeted
Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides, excited for this preprint with @ule_lab & @adrianisaacslab to be out! biorxiv.org/content/10.110…
Adrian Isaacs Lab retweeted
Our new preprint identifies genome wide the RNAs bound by C9orf72 polyPR a great collaboration with @ule_lab and @ShorterLab led by @RubikaBalendra @UKDRI biorxiv.org/content/10.110…
Adrian Isaacs Lab retweeted
NEWS: Researchers led by Prof Adrian Isaacs (@isaacs_adrian, UK DRI at UCL) have developed a biomarker to track the success of therapies targeting the most common genetic cause of frontotemporal dementia & amyotrophic lateral sclerosis 🧬 Read more 👉 bit.ly/38kU420
Adrian Isaacs Lab retweeted
New preprint on developing a sensitive Simoa-based CSF biomarker for C9orf72FTD/ALS great collaboration with @FTDtalk @GENFI1 @jonrohrer @WaveLifeSci @ajh1269 led by @katiewilson1604 and Eszter Katona medrxiv.org/content/10.110…
Adrian Isaacs Lab retweeted
Our latest paper shows a novel role for insulin signalling in C9orf72FTD/ALS elifesciences.org/articles/58565 great work from @AtilanoMagda @UKDRI @UCLIoN
Adrian Isaacs Lab retweeted
C9orf72 polyGR is another FTD/ALS-linked protein whose phase separation is altered by arginine methylation - and levels in brain correlate with disease duration - just out in print and great work from @lougittings and @BoeynaemsSteven link.springer.com/article/10.100…
Nice preview by @katiewilson1604
Nice preview by @katiewilson1604
Congratulations to Dr @JackHumphrey_ and Dr @lougittings who graduated today! Past students of the Isaacs lab 🎓🍾
Adrian Isaacs Lab retweeted
Now on bioRxiv: "FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention” biorxiv.org/content/10.110… Thanks to everyone in @FrattaPietro, @adrianisaacslab, @VincentPlagnol , Marc-David Ruepp and Irene Bozzoni labs.
Adrian Isaacs Lab retweeted
Super happy to see my first, first author paper in print! 🎉👩🏻🔬🙌🏼Thanks to @lashleylab , @adrianisaacslab and @tammarynlashley actaneurocomms.biomedcentral.com/articles/10.11…
The Isaacs lab celebrating the diversity in the lab with our first International Lunch at the @UKDRI Featuring Spanish croquettes, Italian carbonara, Indian chutney, Swedish potato salad, Hungarian stew, English sausage rolls & German kaiserschmarrn!😋 🤤
Adrian Isaacs Lab retweeted
Our new paper by @moenst shows C9orf72 repeat-mediated translational repression and toxicity are rescued by EIF1A rdcu.be/bfe3g @UKDRI
Congratulations to the two new doctors in the lab - @JackHumphrey_ and @lougittings. Both have passed their PhD vivas this month! 🎉🍾📚🧠
Adrian Isaacs Lab retweeted
Our new paper: mutant CHMP2B alters neuronal endolysosome trafficking which is rescued by TMEM106B ASOs! doi.org/10.1093/brain/… @Brain1878 @UKDRI
Come find out about our research into frontotemporal dementia at this free event at #UCL today! Free to attend & lots of interactive activities. Everyone welcome! eventbrite.co.uk/e/alzheimers-r…
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