Carlos Cruchaga @ccrugom
NeuroGenomics and Informatics Center Director. Washington University School of Medicine cruchagalab.wustl.edu St. Louis, MO Joined February 2012-
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Getting ready to present some of our latest findings in using unbiased proteomics to identify novel hashtag#Alzheimer Biomarkers (lnkd.in/gP5p8Zdp) on the 12th Alzheimer's & Parkinson's Disease Drug Development Summit: alzheimers-parkinsons-summit.com
Plasma proteomics identifies new biomarkers and predictive models for dystonia as well as specific dystonia presentations, and pinpoint to immune system, and reactive oxygen pathways to be implicated on disease. onlinelibrary.wiley.com/doi/10.1002/an… @ANA_journals @SomaLogic @WashUNeurology
Great lab, leveraging single cell and statistical transcriptomics to understand neurodegeneration!!!
Great lab, leveraging single cell and statistical transcriptomics to understand neurodegeneration!!!
Interested in Single cell and Multiomics? Register for the NanoCourse! Offered by the experts Dennis Goldfarb, @MollahLab, @TristanLi_Lab, @gzhao11. Learn genomics, proteomics, multiomics. Hands-on practice on data analysis and integration! @papouinlab, neuroscienceresearch.wustl.edu/resources/nano…
Multiple genes modify levels of sTREM2 and risk for #Alzheimer. In this study we integrated genetics and proteomics with functional genomics to identify novel genes implicated on disease pathogenesis @WUADRC @WashUNeurology @SomaLogic …arneurodegeneration.biomedcentral.com/articles/10.11…
We also found that COVID infection affected the levels and many AD relevant plasma proteins; sciencedirect.com/science/articl…
We also found that COVID infection affected the levels and many AD relevant plasma proteins; sciencedirect.com/science/articl…
Check our latest paper: "Harmonization of CSF and imaging biomarkers in Alzheimer's disease", which is part of the ADSP Harmonization consortium. Harmonized CSF data for ADSP samples is already available at vmacdata.org/adsp-phc sciencedirect.com/science/articl…
Special thanks to our close collaborators @NirBarzilaiMD @MD_MilmanS at @EinsteinMed, @ccrugom lab at @WUADRC, and @MorminoLab and Anthony Wagner at @StanfordADRC. And @TobiasWustefeld for the stunning Nature cover. 2/12
It was great to be part of this study by @hammy_oh @JarodRutledge1 and @wysscoray, where we contributed proteomics data from the @WUADRC. Important findings that will help to understand aging processes
It was great to be part of this study by @hammy_oh @JarodRutledge1 and @wysscoray, where we contributed proteomics data from the @WUADRC. Important findings that will help to understand aging processes
Identifying variant and genes associated with #Alzheimers is instrumental to understand the biology of AD and develop treatments. We have an open faculty position to work on large WGS dataset for early-onset, familial AD and endophenotype-based phenotypes: nature.com/naturecareers/…
We have a fully funded Postdoc position for #Alzheimer functional genomics, integrating #IPSC models and multi-omic approaches to identify causal and druggable pathways. More info cruchagalab.wustl.edu/positions/ @WUSTL @Neuro_Genomics
Great lab to do a postdoc or work as a scientist!!
Great lab to do a postdoc or work as a scientist!!
Extremely excited to finally announce I'm starting my own lab on October 1st at the @Neuro_Genomics center @WUSTL @WUSTLmed @WashUNeurology. Want to study Alzheimer, genetics, GWAS, X chromosome, multi-omics, and sex, APOE4, and ancestry effects? Join me! Ads in the thread.
Great representation from the lab #ASHG2023 @GeneticsSociety. Largest Early Onset #Alzheimer GWAS, and a lot of data from our multi-tissue, multi-omics QTL in diverse populations and its applications to complex traits by J. Bradley, @DanWestern2 , @CiyangWang and @chengran2020
Alzheimer's Disease risk variants influence memory phenotypes in #DownSyndrome. We used Polygenic Risk Scores to compare the genetic architecture of Early vs late, and familial and sporadic, and DS. Great collaboration with the AABC-DS consortium @abc_ds_ alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
Reminder - all results from the UKB-PPP protein GWAS can be browsed and downloaded at: ukb-ppp.gwas.eu Full credit to Nick Lehner, @mwoerhe, @KastenmullerLab, @_MatthiasArnold & @ksuhre for building a beautiful interface.
Celeste Karch @karchlab
4K Followers 364 Following Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her.Prof. Melissa E. Murr.. @DrNeuroChic
5K Followers 1K Following Translational neuropathologist | Biomarker enthusiast | Hopeful scientist | Scientific Program Committee @HAIconference #AAIC24 | Advisory board #ADPD2025Alzforum @alzforum
11K Followers 340 Following A news and information resource website helping scientists advance AD research since 1996. Alzforum doesn’t endorse any specific product or scientific approach.Liana Apostolova, MD,.. @ApostolovaLiana
2K Followers 650 Following Cognitive neurologist and Alzheimer's disease researcher, Indiana University Distinguished Professor, Principal Investigator of LEADS, Editor-In-Chief DADMBrian Gordon @BrianGordon81
1K Followers 1K Following Assistant Professor @WUSTL | @MIRimaging | @WUADRC | @PyschIllinois Alumnus | Using cognitive neuroscience and neuroimaging to study #aging and #AlzheimersVeera Rajagopal @doctorveera
17K Followers 4K Following MBBS, MD, PhD | GWAS storyteller | Scientist at Regeneron | Human genetics & drug discovery in Neuroscience & Psychiatry | He/HimDr. Malu Tansey @MaluTansey
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2K Followers 450 Following Neurologist/scientist at Washington University in St Louis. Circadian clocks, glia, neuroinflammation, neurodegeneration. Alzheimer’s doc, soccer/track dad.Shannon Macauley @macauleylab
4K Followers 2K Following Associate Prof, PhD, wife, mom. Alzheimer’s disease | diabetes | brain metabolism | sleep | I ❤️ lactate | lysosomal storage diseases | she/herRachel Buckley 🐨�.. @bucklr01
5K Followers 2K Following Assistant Professor @ MGH/Harvard Med: sex differences in risk for preclinical AD. K99/R00 and DP2 awardee. Co-PI of @healthybrain_au. Aussie. Twin mumSaligrama lab_WUSTL @SaligramaLab
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3K Followers 1K Following Director, Medical & Scientific Relations, Alzheimer’s Association. I talk a lot about Funding/Grants. Views represented here are entirely my own. 🏳️🌈🇧🇷🇺🇸Bruce Lamb @btlamb
2K Followers 325 Following Director of Stark Neurosciences Research Institute at Indiana University School of Medicine. All Tweets are my own (he/him).Washington University.. @WashUNeurology
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3K Followers 758 Following The top ranked open-access neuroscience peer-reviewed journal with a 2022 Impact Factor of 15.1. Official journal of @_BrightFocusAndy Tsai @Andy_P_Tsai
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19 Followers 318 Following Commissioning Editor Journal of Integrative Neuroscience (ISSN 0219-6352, IF 1.8), IMR Press Email: [email protected]João L. Carapinha, P.. @joaocarapinha
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505 Followers 2K FollowingI’mKindaOkay @KGIRLTRIS
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77 Followers 215 FollowingDaniele Mattei, PhD @DanieleMattei4
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5 Followers 81 FollowingIsabellaxu @Isabellaxu15
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10 Followers 53 Following Australian Lady 🇦🇺 Military Wife 🇺🇸 Just a mom helping moms the all natural way | I help people build business | Millionaire mentor 💯BWAMBALE ISAAC KHAN @DrIsaacKhan
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6 Followers 959 FollowingNikolas Karvelas, MD @NikKarvel
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14 Followers 58 FollowingNoah Timko, MPH @NoahTimko
150 Followers 670 Following CRC @Duke_Anesthesia @RealMilesBerger | Periop geriatric cognition/neuro-inflammation & AD research | Aspiring physician-scientist | 🇺🇸🇵🇭Yang Eric Li @YangEricLi
587 Followers 518 Following Husband, Assistant Professor @WashUNeurosurg and @WashUGenetics interested in Bioinformatics, (Epi)genetics, EvolutionFareeha Saadi, PhD @FareehaSaadi1
294 Followers 515 Following Postdoc in @holtzman4 lab at @WUSTL @WashUNeurology |Formerly in JDS lab at @iiserkol | PhD-First generation| Neuroimmunologist| AD| CAA 🧠Cellas A Hayes, PhD @c3llas
3K Followers 3K Following Super Dad | Neuroscientist 🧠 | Postdoc @Stanford_Neuro | Almost an AD Researcher | @StanfordPropel Scholar | YoungGiftedBlack l MS Boy | BiInSci🌈✊🏾🥷🏾Meng Wu @mengwu1002
437 Followers 741 Following interested in microbiome research, stromal cells, mucosal immunology, beneficial microbes and genomics.🌻Celia Lee @Celia173659yxy
245 Followers 398 Following Account is my private account, #BEAUTYCEO, #Yoga, #GOLF #Baseball유지안 @BGI0FLZaadn9Smw
0 Followers 51 FollowingAriya Chaloemtoem @ariyachlt
15 Followers 148 FollowingMerrivab @Merrivab220
102 Followers 1K Following For I know the thoughts I think toward you, says the Lord, thoughts of peace and not of evil, to give you a future and a hope.” Jeremiah 29:11Dave Karlander @DaveKarlander
78 Followers 57 Following Son/husband/dad, coach, student, optimist. Oncology innovation advocate.himatta @h__matta
0 Followers 290 Following Tatlıdır kulağa çalınan melodiler; fakat hiç duyulmayanlar daha tatlı.Patho Mad @patho_mad
60 Followers 135 Following MD Pathology student YouTube channel https://t.co/4mimts39p6 Instagram https://t.co/LuZAXPngdYCeleste Karch @karchlab
4K Followers 364 Following Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her.Prof. Melissa E. Murr.. @DrNeuroChic
5K Followers 1K Following Translational neuropathologist | Biomarker enthusiast | Hopeful scientist | Scientific Program Committee @HAIconference #AAIC24 | Advisory board #ADPD2025Alzforum @alzforum
11K Followers 340 Following A news and information resource website helping scientists advance AD research since 1996. Alzforum doesn’t endorse any specific product or scientific approach.Brian Gordon @BrianGordon81
1K Followers 1K Following Assistant Professor @WUSTL | @MIRimaging | @WUADRC | @PyschIllinois Alumnus | Using cognitive neuroscience and neuroimaging to study #aging and #AlzheimersVeera Rajagopal @doctorveera
17K Followers 4K Following MBBS, MD, PhD | GWAS storyteller | Scientist at Regeneron | Human genetics & drug discovery in Neuroscience & Psychiatry | He/HimErik Musiek @ErikMusiek
2K Followers 450 Following Neurologist/scientist at Washington University in St Louis. Circadian clocks, glia, neuroinflammation, neurodegeneration. Alzheimer’s doc, soccer/track dad.Saligrama lab_WUSTL @SaligramaLab
1K Followers 685 Following #TCR #repertoire #neurological and #autoimmune diseases “We are all smart. Distinguish yourself by being kind.”—Charles Gordon. @[email protected]Li-Huei Tsai @DrLiHueiTsai
8K Followers 308 Following MIT neuroscientist. Director of the Picower Institute for Learning and Memory and the Aging Brain Initiative.Washington University.. @WashUNeurology
2K Followers 349 Following We strive to provide outstanding clinical care, train leading neurologists and scientists of the future and to serve as an international leader in Neurology.Ances BioImaging Labo.. @AncesLaboratory
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472 Followers 140 Following Our goal is to understand the biology of neurodegeneration by using high-dimensional omic data & functional genomic at @WUSTLmedSheng Chih Jin @PETERJIN999
583 Followers 477 Following Assistant Professor @WashUGenetics | genomics | human genetics | bioinformatics | rare disease | pain | STEM advocate | Basketball lover | Cardinals fanJean-Charles Lambert .. @jcl_lambert
1K Followers 569 Following Inserm research director, neuroscientist specialized in Alzheimer’s disease. in EN or/ou en FR 🇫🇷🇪🇺🏳️🌈Anshul Kundaje (anshu.. @anshulkundaje
22K Followers 2K Following Genomics, Machine Learning, Statistics, Big Data and Football (Soccer, GGMU). Post: @anshulkundaje, Threads: anshulkundajeHeather Snyder, PhD @HeatherAlz
5K Followers 2K Following Dr. Heather Snyder is Vice President, Medical & Scientific Relations, at the Alzheimer’s Association. Views represented here are entirely my own.Marc Suárez-Calvet �.. @M_SuarezCalvet
3K Followers 3K Following Neurologist and scientist at BarcelonaBeta Brain Research Center @fpmaragall and Hospital del Mar. @ERC_Research Starting Grant - HeBe Project 🧠🩸Sandro Da Mesquita @Da_Mesquita_S
2K Followers 753 Following Assistant Professor | Dept. of Neuroscience @MayoClinic | Role of the meningeal lymphatic system in 🧠 aging & degeneration 🤓 | Tweets = my opinions & viewsThe National Institut.. @NIHAging
25K Followers 670 Following Official X account of NIH's National Institute on Aging. Dedicated to improving the health of older adults through research. Privacy: https://t.co/6XA3jNUXwcICTS @ WashU in STL @WUICTS
945 Followers 865 Following Funded by @ncats_nih_gov, we accelerate clinical and translational research to improve health outcomes and benefit the well-being of our communities.Oskar Hansson @OskarHansson9
2K Followers 1K Following Professor of neurology. Head of the Clinical Memory Research Unit at Lund University. Consultant neurologist at the Memory Clinic at Skåne University Hospital.IGES @genepisociety
2K Followers 373 Following The International Genetic Epidemiology Society (IGES), a scientific society concerned with the study of genetic components in complex biological phenomena.Ciyang Wang @CiyangWang
8 Followers 12 FollowingMara Dierssen @maradierssen
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67 Followers 42 Following If you're interested in our study, please contact [email protected]Cristina Legido-Quigl.. @DrLegidoQuigley
4K Followers 2K Following Scientist @KingsCollegeLon 🤍 @StenoDiabetes #Dementia & #Diabetes brain-liver axis disease 🔬 🧠 tools #MassSpec #Metabolomics #Lipidomics #Omics #BigDataJoseph Bradley @joebradley53
31 Followers 209 Following NECC Rocket League Emergents Spring Midwest Regional Champion WASHU-STL PHD Student in human and statistical geneticsMichael Wainberg @michaelwainberg
657 Followers 318 Following PI @SinaiHealth and Assistant Professor @UofTPsych @UofTIMS studying brain disease genetics computationallyGuoyan Zhao @gzhao11
436 Followers 578 Following Assistant Professor @WashUGenetics, @WashuNeurology & @wusm_pathology, PhD: @JimSkeath Lab, Postdoc: Stormo Lab, all @WUSTLAniket Mishra @AniketMishra87
133 Followers 431 Following Researcher (CDI-LRU, President/Chancellor nominated tenured position) in statistical genetics at the University of BordeauxAsociación Becarios .. @BecariosFAME
108 Followers 36 Following Cuenta oficial de la Asociación de Becarios de la Fundación Alfonso Martín EscuderoDan Western @DanWestern2
88 Followers 327 Following Graduate of @UWMadisonCALS, PhD student studying genomics of Alzheimer's disease @WUSTLdbbs, Wisconsin sports fanAli Ezzati @AE_MD
717 Followers 720 Following Neurologist | Data Scientist 🧭|@UCI 🎓 Follow me for science, but also unfiltered thoughts about academia! ⚽ is life!Michael Belloy @BelloyMichael
631 Followers 645 Following Assistant Professor @NGI @WashU Neurology. R00 recipient. Alzheimer's Disease, Genetics, Multi-Omics, Brain Imaging, Sex Dimorphism, Ancestry, Resilience.Jaime Grutzendler @JGrutzendler
1K Followers 199 Following Neuroscientist and Neurologist @Yale / Cellular Mechanisms of Neurodegeneration / Glial-Vascular Biology / Translational Neuroscience / Intravital MicroscopyJin-Moo Lee @JinMooLee1
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119 Followers 396 Following Postdoc at Moffitt @MoffittNews, Biomed Informatics PhD alumna👩🎓@Mizzou, Former research scholar @YaleMed ,student👩✈️, 👩🏻⚕️General Surgeon🇨🇳Victoria Alvarez Mart.. @VIctori25068952
153 Followers 121 Following madre , amiga, inmunóloga reconvertida a genetista, investigadora, apostando por equipos para ser mejoresTony Wyss-Coray @wysscoray
5K Followers 328 FollowingHUB6 Home Automation @HUB6smarthome
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507 Followers 305 Following Assistant Professor of Biological Sciences @UNCCharlotte @UNCCBiology researching neuroimmunology focused on neuroinfectious and neurodegenerative diseases.Becky Sale @BeckySale8
132 Followers 330 Following Genetics PhD student @ Vanderbilt University. Views are my ownAndrew Saykin @ASaykin
642 Followers 531 Following Director, Indiana Alzheimer's Disease Research Center, Indiana University (@iadrc_iu); Director, IU Center for Neuroimaging; R.C. Beeler Professor of RadiologyDaniel Panyard, PhD @DanielPanyard
465 Followers 932 Following Postdoc working in the omics of complex disease, epidemiology, genetics, and bioinformatics. @[email protected]MedGen_WashU @MedgenW
401 Followers 216 Following We take pride in providing comprehensive & compassionate clinical care, conducting top-level research,& teaching trainees the art of genetics & genomic medicineamericanair @AmericanAir
1.6M Followers 100K Following Official Twitter for the world’s largest airline. We’re here for you 24/7. For more about us or a formal response, visit https://t.co/uI8dLIDCud.Ángel Martín @angelmartin_nc
1.0M Followers 56 Following 🎤 De gira con "Punto para los locos". Entradas en 👇Andrew D. Martin @WashUChancellor
6K Followers 376 Following Official account of Andrew D. Martin, Chancellor of @WUSTL. #LetsGoWashUSonia Moreno @SoniaMorenoGrau
55 Followers 145 Following Science enthusiast. Human geneticist interested in global health. Researcher at @StanfordMedLaura Cervera-Carles @lcervera89
164 Followers 308 Following Marie Skłodowska-Curie Postdoctoral Fellow at @rna_neurodeg_UB | Communications Chair of @WAutophagy | Interested in #neurodeg #genetics and #autophagy 🧠🧬🔬Ace Alzheimer Center .. @AceAlzheimer
2K Followers 585 Following Som una entitat privada sense ànim de lucre, dedicada al diagnòstic, tractament, recerca i ajuda a les persones amb Alzheimer i les seves famílies.Stroke Pharmacogenomi.. @PharmaEpigenLab
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248 Followers 355 Following Michigan fan, geneticist in pharma, mother of 2. Views here are my own.Quim Miró @quimmiro
5K Followers 5K Following Periodista. Director editorial dels portals temàtics del Grup @comunicacio21: @cultura_21 @exterior_cat i @espaimediacatShonali Midha, M.D. @ShoMidha
1K Followers 1K Following Myeloma Clinical Investigator @DanaFarber @harvardmed via @MoffittNews USF Heme/onc, @NorthwesternU BME, Baker, Jersey girl. Views = my own, not employerDavid Holtzman @holtzman4
3K Followers 38 Following want to understand the scientific underpinnings of neurodegenerationDownstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease jamanetwork.com/journals/jaman…
Thank you immensely to #CureAlzFund @WUSTLmed @WashUNeurology curealz.org/research/trans…
They are both too humble to do it themselves, but it was a great experience to be part of this work led jointly by @PratishthaChat7 and @LisaVermunt and published in @alzdemjournals #TopDownloadedArticle.
Grateful to the American taxpayers for advancing research in rapid progressive dementia @MayoClinicNeuro and to @NIH & @NIHAging for disseminating key findings from studies with @NIHalsatyadev and @Lindseykuchen (learn more via @ANA_journals): nia.nih.gov/news/scientist…
So proud of my team representing at #CROI 2024 this year!! Excited that our lab was able to share so much of our new research!
Attended the Americas Committee for Treatment and Research in Multiple Sclerosis (#ACTRIMS2024) with my PhD students @DrishyaMainali , @anjie_ge & Yvonne . It was wonderful to catch up with my colleagues and hear about the most recent research in MS. #iWiMS #ACTRIMSforum
"While many circRNAs are probably non-functional, the fact that cells have evolved a dedicated mechanism dependent on Ran-GTP and exportin-2 to export circRNAs highlights the potential importance of circRNAs in the biology and function of cells."
Nature research paper: Nuclear export of circular RNA go.nature.com/3HY83ZC
Interested in Single cell and Multiomics? Register for the NanoCourse! Offered by the experts Dennis Goldfarb, @MollahLab, @TristanLi_Lab, @gzhao11. Learn genomics, proteomics, multiomics. Hands-on practice on data analysis and integration! @papouinlab, neuroscienceresearch.wustl.edu/resources/nano…
Thrilled to share our latest study to understand the genomic and epigenetic roles of TDP-43 in regulating local gene expression, long range promoter-enhancer interaction and transposable elements expression via R-loop and 5hmC crosstalk. cell.com/cell-reports/f…
Impressive new work on modifiers of sTREM2 and links to AD by @ccrugom ! Check it out!
Multiple genes modify levels of sTREM2 and risk for #Alzheimer. In this study we integrated genetics and proteomics with functional genomics to identify novel genes implicated on disease pathogenesis @WUADRC @WashUNeurology @SomaLogic …arneurodegeneration.biomedcentral.com/articles/10.11…
Congrats @steph_loomis for expertly leading our study of amyloid-related imaging abnormalities in the Ph3 aducanumab (Aduhelm) trials. This is the first study to systematically evaluate ARIA via GWAS & exWAS, with breakdowns by severity & APOE genotype. neurology.org/doi/10.1212/WN…
Really nice work out today from Pete Millar in the @AncesLaboratory studying structural changes in Autosomal Dominant Alzheimer Disease.
'Advanced structural brain aging in preclinical autosomal dominant #AlzheimersDisease' Peter R Millar @BrianGordon81 Julie K Wisch... @AncesLaboratory & Eric M McDade @WashUNeurology @WUSTL #ADAD #StructuralMRI bit.ly/3v6JOoT
Many individuals contributed to this study including @AncesLaboratory @Schultz_SA @neuroplebeian @BenzingerNeuro1 @ccrugom @laura_actg @karchlab @MathiasJucker @RandallBateman3 and may others not on Twitter/X
Excited to announce that I have been awarded an NHMRC Investigator Grant this year. Congratulation to all the other recipients! Very excited to work on this program at the University of Sydney @nhmrc @Sydney_Uni #neuroscience #neuroinflammation teams.microsoft.com/l/message/19:1…
Special thanks to our close collaborators @NirBarzilaiMD @MD_MilmanS at @EinsteinMed, @ccrugom lab at @WUADRC, and @MorminoLab and Anthony Wagner at @StanfordADRC. And @TobiasWustefeld for the stunning Nature cover. 2/12
It was a loooong (and painful) process, but the new paper from the lab has been accepted for publication! Cell-free RNA signatures predict Alzheimer's disease. So proud of @ACisternaGarcia and @SashkaBeric for the hard work! Link: sciencedirect.com/science/articl…
Talk: Anjali Das - Cell-type specific non-coding rare variant association tests reveal novel Alzheimer’s disease relevant functional annotations and loci. Thursday 10:45-11:00 am - Room 207A eppro01.ativ.me/appinfo.php?pa…
Thank you @Bo_Zhang_WashU and Dr. Erica Scheller for giving @tascya the opportunity to share our work at the Center of Regenerative Medicine (CRM @wustlcrm ) Bioinformatics Work in Progress (WIP) meeting!
fantastic work by @ccrugom! 🎉 #sisterCWOW
You can read the full manuscript here: science.org/doi/10.1126/sc…, and use our user-friendly browser proteomics.wustl.edu to explore this data