David Li @davidycli
just a guy trying to make drugs that help patients San Francisco, CA Joined July 2014-
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reality bending vs truth-seeking there's a duality, natural tension between the two but do both and you are a master of the universe
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sorry to report but on the current trajectory there will only be two types of biotechs in the US in < 5 years: 1. tech bio 2. chinese CRO wrappers
Building a globally competitive US biotech in 2025: > Focus on novel biology why? —> The Chinese biotech VC ecosystem struggles to fund novel biology (actively disincentivizes going after non clinically validated targets) —> The US biotech ecosystem struggles to execute on…
Worth a read on this Sunday morning fs.blog/great-talks/mu…
Watching this team execute over the last 5+ years has been an incredible privilege stoked to be along for the ride as a (small) early check ignored the doubters, systematically knocked down questions about the modality, about the target, about how high the bar was in solid…
Watching this team execute over the last 5+ years has been an incredible privilege stoked to be along for the ride as a (small) early check ignored the doubters, systematically knocked down questions about the modality, about the target, about how high the bar was in solid…
** a vision for the future AI native workflow for drug discovery R&D** scientist assesses emerging targets in a particular field of cancer, with assist of literature and competitive intel natural language co-pilot uses expertise to decide target X is interesting to try to…
**a new "foundation model for bio" seems to be released every month - when will they actually impact drug discovery? ** the last 2 years has seen the release of a ton of foundation models for bio: - alphafold3 and related protein folding models for predicting structure -…
**A grand unified theory on what will happen in biotech in the next 10-20 years** the two major forces reshaping industrial biotech in the next decade are: 1. China 2. AI - and they're critically linked how? China's low R&D cost basis democratizes execution by providing…
The unfortunate market reality for "Tech Bio" selling into pharma as a tech solution is dangerous work. The market is (usually) simply not large enough, and double whammy is that sales cycles are loooong let's take a look at the tech startups that have started in this space…
Benchmarks in AI for science - and why they are fundamentally not aligned with industry use cases there are a long tail of benchmarks in AI x science space; a non exhaustive list (focused on drug discovery): - ProteinBench: evaluating protein foundation models created by…
American biotech needs more of this founder energy in competing with China
American biotech needs more of this founder energy in competing with China
How close are we to widespread adoption of industrialized AI agents in biotech & drug discovery? Progress has accelerated in the last 6 mo: - @ProjectBiomni, general purpose scientific AI agent automating literature reviews, hypothesis generation, protocol design,…
** biotech's broken business model and what to do about it ** We are now in year 4 of a biotech bear market The key driver of negative sentiment? Biotech public markets sentiment refuses to recover Since Dec 2022 to today, Nasdaq is up from 10,400 -> 19,400, or 85%+ XBI…
A lot of things in life are just focusing on doing one thing really well - marriage / serving and growing with one person - career / one highly differentiated skill - making investments / honing one approach to finding alpha - raising money / becoming world class at sales -…
A lot of things in life are just focusing on doing one thing really well - marriage / serving and growing with one person - career / one highly differentiated skill - making investments / honing one approach to finding alpha - raising money / becoming world class at sales -…
No product, no pipeline, $10.5bn mc Been doing this all wrong 🧐
equiv in biotech is when their pipeline gets closer to market / late clinical
equiv in biotech is when their pipeline gets closer to market / late clinical
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Ava Amini @avapamini
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