Erick Turner @eturnermd1.bsky.social @eturnermd1
Former reviewer of psych drugs for FDA, back when they had backbone vs Pharma. User of FDA reviews to sort out truth vs lies in publ'd articles on clin trials. scholar.google.com/citations?user… Joined November 2015-
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Cost of developing new drugs may be far lower than industry claims, trial reveals theguardian.com/global-develop…
Join this Thursday! @woodymatters at Consilium! Sign up here: mailchi.mp/consilium-scie… @Pharmed_Out @eturnermd1 @Jhickmana @HealthSenseUK @NaudetFlorian @Altostrata @MedWithdrawal @PGtzsche1 @AliBeckZeck @pharmvigilance @DSRUDrugSafety @DavidJuurlink @drkevinknopf
Pharma marketing in 1919 in 🇫🇷: Cocaine hydrochloride, recommended « for speakers, singers and teachers ».
Here’s a periodic reminder that our 16 years of work on HealthNewsReview,org can still be found on the Internet Archive Wayback Machine: web.archive.org/web/2019033117…
Never before had the American Academy of Neurology advertised a drug in its annual Congress. The first #AANAM plenary started with a 5-minute video on how to deliver lecanemab to patients with #Alzheimers. As @AANmember I feel betrayed. The AAN sold some of its soul today.
Another example of FDA lowering the bar 4 approval. When a trial fails on the primary outcome, it's negative or (at best) "supportive", but then you'd need another trial 2 B strongly positive. Here it looks like there WAS no 2nd trial since Chris said "a [singular] large trial".
Another example of FDA lowering the bar 4 approval. When a trial fails on the primary outcome, it's negative or (at best) "supportive", but then you'd need another trial 2 B strongly positive. Here it looks like there WAS no 2nd trial since Chris said "a [singular] large trial".
Hard 2 fathom that this unethical practice isn't also illegal. Reminds me of @jsross119's paper on guest authorship 4 Vioxx m-script, but authorship shenanigans came 2 light only via litigation. Here authorship is being sold in way that's blatant & shameless. @millerbioethics
Hard 2 fathom that this unethical practice isn't also illegal. Reminds me of @jsross119's paper on guest authorship 4 Vioxx m-script, but authorship shenanigans came 2 light only via litigation. Here authorship is being sold in way that's blatant & shameless. @millerbioethics
"Pazdur says he would like to see more diverse views during the OPH session, not just individuals curated by the sponsor to present ‘a very positive picture’ of the drug." "Curated"...that's a good word to describe the process
"Pazdur says he would like to see more diverse views during the OPH session, not just individuals curated by the sponsor to present ‘a very positive picture’ of the drug." "Curated"...that's a good word to describe the process
10 doctors on FDA panel for Abbott heart device had financial ties to the company nbcnews.com/health/health-… via @NBCNews
Good to see another null trial published. Another step towards destigmatization and a more realistic and credible body of published literature
Good to see another null trial published. Another step towards destigmatization and a more realistic and credible body of published literature
🕵🏽♀️Want to become an evidence detective? 🛟Want to avoid common pitfalls when reading clinical drug trials? Watch our webinar recording ⤵️ #CriticalAppraisal pearls for clinicians: ti.ubc.ca/evidence-detec… Featuring @LessIsMoreMed + @amtejani 😍😍
Report from ICER on MAPS' MDMA therapy. 'we have substantial concerns about validity of results...unblinded...very strong prior beliefs of those involved in the trials...therapists encouraged favorable reports by patients and discouraged negative reports' icer.org/wp-content/upl…
Read this report on MAPS (now Lykos) MDMA trials. I don’t know what bearing this will have on FDA.
Read this report on MAPS (now Lykos) MDMA trials. I don’t know what bearing this will have on FDA.
1/2 Very important article, in the most well known mainstream US psychiatry rag. "Lastly, and most importantly, we have an ethical duty to our patients to take an honest look at the evidence derived from our research when making decisions that will impact their mental health."
1/2 Very important article, in the most well known mainstream US psychiatry rag. "Lastly, and most importantly, we have an ethical duty to our patients to take an honest look at the evidence derived from our research when making decisions that will impact their mental health."
Michael Dougherty @doughertyorama heads the Psychology Dept @UMBaltimore. He has been updating tenure and promotion criteria within his dept and beyond to focus more on rigorous research. He's also developed a toolkit for others to use: osf.io/z9xsr/
In case you didn't see it yet: I'm hiring a postdoc to work on improving reproducibility in research. Application deadline March 20: ki.varbi.com/en/what:job/jo…
Eiko Fried @EikoFried
36K Followers 2K Following Associate Prof @UniLeiden. Mental health & data science. Building early warning system for depression (https://t.co/rw3oC2Kol0).Dr James Davies (PhD).. @JDaviesPhD
36K Followers 222 Following Father - Husband - Writer - Assoc Professor of Medical Anthropology & Psychology (Ph.D @UniofOxford). Practicing Psychotherapist (UKCP). Previous NHS. @appgpddDr. Roger McFillin @DrMcFillin
31K Followers 665 Following Clinical Psychologist| Radically Genuine Podcast⭐️top 1% in global downloads/Substack: https://t.co/SGUGA2ysHrAwais Aftab @awaisaftab
22K Followers 3K Following Psychiatrist with philosophical interests | @aapp_PhilPsych @philpsychpsy | Subscribe to my blog - Psychiatry at the Margins | https://t.co/EKwMa3uRq7Michael P. Hengartner.. @HengartnerMP
8K Followers 1K Following Senior lecturer and researcher in clinical psychology, psychopathology, evidence-based medicine, psychiatric epidemiology, and social psychiatry.Martin Plöderl @PloederlM
3K Followers 636 Following Clinical Psychologist, Psychotherapist, Cyclist, bin privat hierKindly #deprescribe -.. @Altostrata
5K Followers 5K Following Founded https://t.co/LZKzf0qLE0 2011. 6,000 case histories of #psychiatric drug #tapering & #withdrawal. Inventor of #Withdrawalology in #deprescribing.David Juurlink @DavidJuurlink
68K Followers 872 Following Internal Medicine, Clinical Pharmacology/Toxicology and drug safety research @Sunnybrook and @UofTMedicine. Inexplicably fortunate husband.James Moore @jf_moore
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11K Followers 352 Following Trainee psychiatrist/Researcher @NELFT @UCLPsychiatry (honorary) . Maudsley Deprescribing Guidelines: https://t.co/MdD00q9Yd1 (US) https://t.co/9eUVpPj52p (UK)Harriet Vogt @shvogt
3K Followers 4K Following Psychologist qualitative researcher. Holistic health. Individual’s personal experiences not prescriptive theories. #patientsafety first. Views mine.TranspariMED @TranspariMED
4K Followers 3K Following Working to end evidence distortion in medicine #clinicaltrials #transparency #openscience Tweets by @Marguerite_ORFlorian Naudet @NaudetFlorian
3K Followers 957 Following Meta-researcher, Clinician, Professor @RennesUniv, Senior member @InstUnivFr, affiliate @METRICStanford / Tweets are my own.Mad In America @Mad_In_America
35K Followers 29K Following Rethinking Psychiatry Advocacy, Blogs, News, Podcasts https://t.co/ZYsL5pC6uG and ResourcesBOB FIDDAMAN💜🇵�.. @Fiddaman
6K Followers 429 Following Researching Drug Company and Regulator malfeasance for 17+ years. New novel, 'No Other Man' out now! Villa fan. AC/DC Nut.JD @jill_d35
4K Followers 3K Following Capt Blackadder: Just one tiny flaw in the plan. Lt George: Oh, what was that? Capt Blackadder: It was bollocks. Being British. Now there isn't even a plan....Jesus Ramirez-Bermude.. @JRBneuropsiq
28K Followers 11K Following MD PhD ⚬ Clinical Narratives & Scientific Research ⚬ Neuropsychiatry ⚬ National Institute of Neurology and Neurosurgery / SNI2 ⚬ English/Spanish TweetsJohn Mandrola, MD @drjohnm
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97 Followers 41 Following Surviving spouse of Laurie, a co-founder of the Benzodiazepine Information Coalition. We need a reformed psychiatry based on better science. #PrescribedHarmCherySandt @CherySandt12117
22 Followers 898 Followingname @alienatefurther
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122 Followers 660 Following Bioinformatics PhD student in @simonrasmu's group at @UCPH_CPR, focusing on psychiatric genetics. Co-supervised by @AndrewSchork and @MichaelBenros.Collin Dougherty @CollinD0ugherty
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4K Followers 3K Following you've got your whole life to do something and that's not very longgrimacelover @grimacelover
144 Followers 565 Following Aspiring Lumpen Prole. Xenu did nothing wrong. Reality or nothing.kari @kariikat
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87 Followers 294 FollowingBrandon @BrandonLukeMc
341 Followers 2K Following Working-class dude ill-advisedly joining the laptop class. Once a lefty, drifting rightward. PhD candidate. Hunter.Crémieux @cremieuxrecueil
88K Followers 911 Following I write about genetics, 'metrics, and demographics. Read my long-form writing at https://t.co/8hgA4nNS2A.Elon Reeve Musk @elonmusk88908
428 Followers 5K FollowingEiko Fried @EikoFried
36K Followers 2K Following Associate Prof @UniLeiden. Mental health & data science. Building early warning system for depression (https://t.co/rw3oC2Kol0).Awais Aftab @awaisaftab
22K Followers 3K Following Psychiatrist with philosophical interests | @aapp_PhilPsych @philpsychpsy | Subscribe to my blog - Psychiatry at the Margins | https://t.co/EKwMa3uRq7Michael P. Hengartner.. @HengartnerMP
8K Followers 1K Following Senior lecturer and researcher in clinical psychology, psychopathology, evidence-based medicine, psychiatric epidemiology, and social psychiatry.Maarten van Smeden @MaartenvSmeden
42K Followers 837 Following Statistician • associate prof • statistics/epidemiology/AI methodology, Julius Center @umcutrecht • own viewsMartin Plöderl @PloederlM
3K Followers 636 Following Clinical Psychologist, Psychotherapist, Cyclist, bin privat hierDavid Juurlink @DavidJuurlink
68K Followers 872 Following Internal Medicine, Clinical Pharmacology/Toxicology and drug safety research @Sunnybrook and @UofTMedicine. Inexplicably fortunate husband.Mark Horowitz @markhoro
11K Followers 352 Following Trainee psychiatrist/Researcher @NELFT @UCLPsychiatry (honorary) . Maudsley Deprescribing Guidelines: https://t.co/MdD00q9Yd1 (US) https://t.co/9eUVpPj52p (UK)TranspariMED @TranspariMED
4K Followers 3K Following Working to end evidence distortion in medicine #clinicaltrials #transparency #openscience Tweets by @Marguerite_ORFlorian Naudet @NaudetFlorian
3K Followers 957 Following Meta-researcher, Clinician, Professor @RennesUniv, Senior member @InstUnivFr, affiliate @METRICStanford / Tweets are my own.Adam Cifu @adamcifu
25K Followers 811 Following Internist, professor, patient. Author: Ending Medical Reversal; Symptom to Diagnosis; Sensible Medicine. Podcasts: S2D & Clinical Excellence. Loves Baseball.BOB FIDDAMAN💜🇵�.. @Fiddaman
6K Followers 429 Following Researching Drug Company and Regulator malfeasance for 17+ years. New novel, 'No Other Man' out now! Villa fan. AC/DC Nut.John Mandrola, MD @drjohnm
66K Followers 2K Following Heart rhythm doc, writer for @Medscape, host of This Week in Cardiology podcast, cyclist, #MedicalConservative. The more you see, the harder medicine getsGordon H. Guyatt @GuyattGH
14K Followers 565 Following Promoting use of the best evidence and patient values and preferences to inform optimal clinical and health policy decisions. https://t.co/JxbX7cZMgyRobert Howard @ProfRobHoward
15K Followers 2K Following UCL old age psychiatrist | Improving dementia and mental health treatment | Independent trials | Layla | Talk to me about academic careersVenk Murthy MD PhD @venkmurthy
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1K Followers 304 Following Evidence Based Health Care // Pragmatic Evidence || Senior Scientist @RC2NB @Unibasel || RT/like no endorsementBalázs Szigeti @psybalazs
2K Followers 621 Following Psychedelics | Placebo effect | Data science | Citizen science | Real world evidence Currently at @UCSF's @TrPR_program, associate at @Imperial_PRGTherapeutics Initiati.. @Drug_Evidence
7K Followers 4K Following UBC-based, independent, evidence-informed, practical #BetterPrescribing information for #Physicians, #NursePractitioners, #Pharmacists #MedEd #CME RT≠endorseDaniël Lakens @lakens
31K Followers 2K Following Experimental Psychologist @TUeindhoven. Co-host of @nulliusverbapod. Improving Stats Textbook https://t.co/PxngSRZ02S Omnia probateDr Joanna Moncrieff @joannamoncrieff
25K Followers 90 Following Critical psychiatrist, author and researcherCorey Davis @coreysdavis
4K Followers 3K Following you've got your whole life to do something and that's not very longJurrien Timmer @TimmerFidelity
185K Followers 1K Following Dir. of Global Macro @Fidelity. Student of history, chart maker, cyclist, cook. Helping investors break thru the clutter. Views are mine. https://t.co/9Pn7wGwMzpMario Malički @Mario_Malicki
593 Followers 365 Following Editor-in-Chief of Research Integrity and Peer Review. Research Scholar at SPORR Stanford. Meta-researcher. https://t.co/PRHqlhMN82…Alberto J Espay @AlbertoEspay
8K Followers 630 Following #Neurology professor @uofcincy. Advocate of precision medicine in #Parkinsons & #Alzheimers. Cofounder of Regain to correct proteinopenia. Author #BrainFables.Anna Abalkina @abalki.. @AbalkinaAnna
2K Followers 522 Following Researcher • Creator of RW #Hijackedjournals checker • Academic misconduct •Plagiarism • #papermills •Scientometrics •Corruption in higher educationAuthorship for sale @author_for_sale
2K Followers 7 Following Trying to raise awareness of the sale of authorship of scientific papers by sharing adverts as they appear.Jules Evans @JulesEvans11
6K Followers 2K Following Director of Challenging Psychedelic Experiences Project, author of various books, editor Ecstatic IntegrationMushtaq Bilal, PhD @MushtaqBilalPhD
228K Followers 36 Following I simplify the process of academic writing | Helped 5,000+ become efficient academic writers with AI | Work @SyddanskUni | Join 600 using https://t.co/SKfrXx2V5qKatharine Sanderson @scrinders
675 Followers 1K Following Senior reporter, Nature. 2021 British Journalism Awards finalist, @ABSW board member, solo parent, cyclist and rugby fanmallory (she/her)💬 @this_is_mallory
30K Followers 1K Following hi, I’m mallory 🙋🏻♀️ let’s talk about misinformation, the ✨Wellness✨ industry, influencers, and MLMs | views are my ownscienceOS @the_scienceOS
86 Followers 6 Following scienceOS integrates AI into literature research to support scientists in driving discoveries and tackling global problems. #scienceOSMariah Hoye @mariahhoye
538 Followers 861 Following Scientific Project Manager at NINDS in the Office of Research Quality Views are my own! @mariahhoye.b**https://t.co/ebCDPXcOp8Community For Rigor @comm4rigor
529 Followers 179 Following @Penn based, @NIH @NINDS4Rigor funded initiative to improve rigor in scientific research. We learn more every day.Drug Monkey @drugmonkeyblog
9K Followers 240 FollowingJames Larkin @LarkinJames
2K Followers 4K Following RCSI Postdoctoral researcher. Research interests: conflicts of interest, the pharmaceutical & medical device industries, multimorbidity, out-of-pocket payments.Julia Etkin @juliaetkin
139 Followers 365 Following @HarvardMed @HMSbioethics MBE Candidate | @YaleMed @Yale_CRRIT Postgraduate-Predoctoral AssociateDr Usman Hamdani @hamdani_usman
1K Followers 4K Following Research Lead, Mental Health Translation @Wellcometrust views are my own!Daniel Litt @littmath
37K Followers 871 Following Assistant professor (of mathematics) at the University of Toronto. Algebraic geometry, number theory, forever distracted and confused, etc. He/him.Consensus @ConsensusNLP
9K Followers 399 Following AI-powered, academic search. We use language models to surface expert answers from research papers. Create an account today: https://t.co/VTvqZU6W9FNINDS Office of Resea.. @NINDS4Rigor
524 Followers 401 Following Official account of NINDS/ORQ, part of @NIH We promote rigorous research practices and transparent reporting RTs ≠ endorsements Privacy Policy: https://t.co/0eBQVXO77HChristopher Rudge @chrisrudge
2K Followers 1K Following Lecturer @sydneylawschool and @sydneyhealthlaw. Chief Investigator @cellhorizons MRFF. #therapeuticgoods #mentalhealthlaw #welfarelaw #medicalregulationHéloïse Rambert @Heloiserambert
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1K Followers 3K Following Professor Diabetic Medicine + Health Policy. Director Diabetes Trials Unit; WHO TAG-Diabetes; former TAC Chair NICE. Anglo-Santa Monican.Jack Wilkinson @jd_wilko
8K Followers 6K Following Stats and methodology. #IVF & #infertility research. Detecting fabricated data. Tweets do not reflect employer opinion. Centre for Biostats, @UoMJosef M. Klein @ResurgeQuality
190 Followers 296 Following Spends spare time here 'with' Research Integrity/Data Transparency in Med & Chem Industry. And hopefully one day 'for' it. Proficient in EU Law & Chemistry.bluesky @bluesky
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763 Followers 376 Following Making every word count so your bank account does too | Dive in for tips on how Emails + Newsletters can fund your freedom | Your next chapter starts here.Open Evidence @OpenEvidence
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717K Followers 3K Following ISW is a policy research organization focused on U.S. national security. Email: [email protected]. For more: https://t.co/FO1PVyOnYB🏳️⚧️Graph.. @GraphCrimes
112K Followers 527 Following Graph High Crimes & Misdemeanors | Moderate amounts of shitposting | She/her | GraphCrimes (at) Gmail for business stuffThis is why the expectancy effect in psychedelic trials cannot and must not be ignored. It makes is very, very, very hard to interpret results from them. We need new methodologies. 👇🏼👇🏼👇🏼
Worst part of psychedelic trials is saying no to potential participants. We receive 100s of calls from ineligible folks who feel they have no options. When I discuss TMS, ECT, ketamine, MAOIs, trauma therapy, etc many are totally surprised. Makes me sad for them and psychiatry.
Leonard Cohen, no less. 🥰
cows freaking love music & it is the wildest thing to watch 😭
@Michal45945708 @bmj_latest Did they split the sample? But yes, it's problematic.
@PloederlM @bmj_latest That's definitely the biggest errors, but what do you think about including results from one study (Ross 2016) at different time points (2 and 6 weeks) as separate data points? It makes no sense to me. x.com/michal45945708…
@bmj_latest @Athina_Metaxa12 It makes to include separately include results at different time points (2 weeks and 6 weeks) from the same study in one analysis!
@HengartnerMP @bmj_latest Yes, I only had one hour and pointed out two obvious discrepancies of the SMD, plus a critical note about the judgment that all studies had low risk of bias. This can't be true, given that bias resulting from breaking the blind.
1. It's the 3rd meta-analysis making a "standard error" within a few weeks: the SD was conflated w the SE, leading to absurdly large effect sizes. This should not pass peer review. Here it happened in @bmj_latest. It has open peer-review, so let's see. The other 2 examples ->
Whoa! Meta analysis of psilocybin in the tx of depression. g=1.3. Look at the three studies with super size effects. This is too good to be true, no? bmj.com/content/385/bm…
@eturnermd1 Plus a new acronym! TEE Treatment effect estimation Insta-metaphor.
@PloederlM @tkaiser_science @MatthewBJane @EikoFried @IoanaA_Cristea @HengartnerMP @PubPeer @bmj_latest Sorry for that. This scientist -who prefer to remain anonymous- should be not allowed to have collaborations. :) The problem is that he is also having a look at two other manuscripts right now and have work for the next WE... I might find some time in the next week however.
@GjPsych The “more conventional” is not a proper post hoc justification for outcome switching of course. If you think conventional is better just register the BDI as primary outcome then. They didn’t, and you can’t have it both ways ;)
Saw a reference to the 2022 psilocybin Nature Medicine paper yesterday. Revisited the study and to my surprise found that the journal still didn't publish a correction/expression of concern. So here a brief summary why this paper requires a correction. eiko-fried.com/psilocybin-202…
The creator of the gif in the OP/paper's lead author (@eturnermd1) has a bio reading: "Former reviewer of psych drugs for FDA, back when they had backbone vs Pharma." So maybe the FDA isn't as conservative as it once was, or as this report suggests it is, compared to academics.
Thanks to all of you & reddit, we correctly identified the car as a Hyundai Kona 1. gen. model, which helped the police find the car / person responsible for the hit & run. This means (1) we have someone else pay our repairs, & (2) case picked up by prosecution + consequences.
Tweeps: This person just rammed my car in a hit and run. My car-fu is pretty bad — can anyone identify the model? (We’re fine but it would help the police who said they can’t tell the model)
@EikoFried People who purchase the blue check mark vs. not are likely different types of people with different levels of interest in promoting their accounts. The better experiment would be to choose accounts without the blue check mark and randomly give half of them the blue check mark…
Brilliant piece, again, by @awaisaftab. So many contradictions in how people write and speak of psychiatry. "Is taking SSRIs an act of pathologizing one’s reactive stress, but taking MDMA is to boldly question the medical model?" Please read.
People Are Stumbling From One Misguided Narrative About the Medical Model to Another psychiatrymargins.com/p/people-are-s…
#Esketamine worked on day #1, but was no better than placebo after a month in this large, randomized, industry-sponsored trial in treatment resistant #depression from China. Surprising? Several unpublished trials showed a similar fade.
Yay! Three years after @raoult_didier @Pr_Chabriere_E and @IHU_Marseille filed a complaint against me for harassment and blackmail, the Marseille Procureur tells me today they could not find any grounds for criminal prosecution.
New unfollows signal to me that some people now see me as "problematic" for standing up for facts. Good thing is that my integrity is intact.
Another option is to join or start a local community, like via a @ReproducibiliT journal club, at your institution to discuss issues and share best practices related to rigor and transparency. reproducibilitea.org