Chris Palmer, MD @ChrisPalmerMD
Harvard #psychiatrist working at the interface of #metabolism and #mentalhealth. Author of Brain Energy, available now! https://t.co/bZ0wRxj2Yk. ChrisPalmerMD.com Belmont, MA Joined February 2013-
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"it is now known that this hormone (insulin) is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb" Wowzers! I have investigated insulin receptors/ IGF1/2 in the brain in rats, but had no idea..
"it is now known that this hormone (insulin) is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb" Wowzers! I have investigated insulin receptors/ IGF1/2 in the brain in rats, but had no idea..
Sometimes, I'm surprised how frequently celebrities, journalists, podcasters, and other "influencers" share with me that they have family members with severe mental illness. I then have to remind myself that just about everyone knows someone with a severe mental illness.
Mental health includes feeling good, having energy, being motivated, and thinking clearly. Our treatments should improve these domains, not impair them.
Insulin is produced in the brain. mdpi.com/1422-0067/24/7…
Addressing the mental health crisis requires more than just increased funding for treatment; it requires the understanding and development of more effective treatment and prevention strategies. Science can lead the way. Believe it or not, we have a lot of it. #BrainEnergy
@drockerr @ChrisPalmerMD I had debilitating bipolar disorder & GAD. Past tense. 12 hosp trips & 46+ meds that I remember & nothing helped. It’s now in remission via ketogenic therapy. I take NO drugs. When hope is actualized after decades of being told it doesn’t exist, you’d be stunned what we can/will…
@ChrisPalmerMD When you pray and beg God for help because you have a beautiful baby boy and all you want is to be a healthy and happy mom and God answers your prayer primarily by changing your diet… it IS a miracle!
When you treat patients with schizoaffective disorder for over 10 years and see them suffer relentlessly, lose jobs and relationships due to their illness, and lose hope... and then they try the ketogenic diet and regain their lives... it feels like a miracle. Maybe it is.
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels ... at least in worms. nature.com/articles/s4155…
Mitochondria in different organs and tissues can function differently from each other. This study finds striking differences in the bioenergetics of brain and liver mitochondria in mitochondrial disease: an important aspect of the brain energy theory. sciencedirect.com/science/articl…
"Every single psychological condition is tied to worse biological aging" - @RyanSmithEpiAge . One of my favorite quotes from this weekend's Longevity Docs meeting.
"more and more evidence shows that mitochondrial dynamics dysfunction may play an important role in the occurrence and development of depression" Science can lead to better treatment and prevention strategies.
"more and more evidence shows that mitochondrial dynamics dysfunction may play an important role in the occurrence and development of depression" Science can lead to better treatment and prevention strategies.
@Grimeiro Even this paper analyzes people that don't respond to the medications. It's not claiming that this happens for all people, only those who respond to the antidepressant. In reality, they can't fully know that these changes in energy metabolism are due to the antidepressants, as…
How do Celexa and Lexapro (SSRI's) work when they do work? This analysis concludes... "These findings suggest that mitochondrial energetics—including acylcarnitine metabolism, transport, and its link to β-oxidation—and lipid membrane remodeling may play roles in SSRI treatment…
How do Celexa and Lexapro (SSRI's) work when they do work? This analysis concludes... "These findings suggest that mitochondrial energetics—including acylcarnitine metabolism, transport, and its link to β-oxidation—and lipid membrane remodeling may play roles in SSRI treatment…
It was a moving day at the #dumpthescales march in London, organised by the relentlessly determined @HopeVirgo. There is so much pain, loss, and work to do to help people with eating disorders, but another way is possible. I was so glad to take part.
.@AgnesAyton talking about the importance of patients, clinicians, carers and researchers working together to improve eating disorder treatment and prevention. We ALL have a role to play (*Before she was rudely interrupted by a extremely loud helicopter!) #dumpthescales
💕'I believe in full 100% recovery. And a full life after recovery which can be anything you want it to be'💕 Inspiring words from @meganjcrabbe #dumpthescales
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"it is now known that this hormone (insulin) is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb" Wowzers! I have investigated insulin receptors/ IGF1/2 in the brain in rats, but had no idea..
Insulin is produced in the brain. mdpi.com/1422-0067/24/7…
I was today's years old when I learned that #insulin can be produced in the brain... 😲🧠 #NeuroTwitter #BrainHealth
Insulin is produced in the brain. mdpi.com/1422-0067/24/7…
Wow. Did not know this.
Insulin is produced in the brain. mdpi.com/1422-0067/24/7…
@ChrisPalmerMD This is really interesting thx! - given memory deficits in eating disorders @AgnesAyton - question is, how to increase insulin production (rather than sensisitivity, although also important of course) in the brain? Exercise? Memory training? Reduced stress/threat perception?
@ChrisPalmerMD What a fascinating revelation. Not just the pancreas, wow. I would like to pretend I forgot that, but I never knew it.
🙀
Insulin is produced in the brain. mdpi.com/1422-0067/24/7…
@ChrisPalmerMD Wow! A couple key takeaways: brain produced insulin is conserved across many species, even invertebrates. And the brain produces less insulin when obese and/or insulin resistant, a double whammy considering less will cross the BBB. Talk about brain fog!
@ChrisPalmerMD This is remarkable.
@ChrisPalmerMD Ooh very interesting! Thanks Dr Palmer ☺️
@ChrisPalmerMD I like to say of these things that in the context of what we thought we knew, it is miraculous.
@ChrisPalmerMD and you can take her daily for a walk in the spring sunshine then that feels like a miracle - Christos Anesti! Truly He is risen but actually it's basic biochemistry - bypass glycolysis give your neurons the energy they need .
@ChrisPalmerMD When your daughter has been grievously ill with violent hebephrenic schizophrenia for 10 years such that she is violent 35 times a month (needs restraining or isolation) and you put her on a KD and that violence reduces to just twice a month
@JourneyofHope4U @drockerr @ChrisPalmerMD I used to say “hope is a four-letter word” because I truly believed hope was just a dirty trick. I heard over and over, don’t give up hope and thought “you say that yet offer me none! I may be ill but I’m not stupid, hope doesn’t really exist.” I am profoundly glad I was wrong.
@ChrisPalmerMD We’re recording a video on basically this topic tomorrow! Thank you for being part of what helped me find ketogenic therapy and why I’m getting huge pieces of my life back.
@ChrisPalmerMD No doubt. It's a miracle! 🙏🏻✨