Tom Richardson @iTomRichardson
Statistical Geneticist at @GSK Bristol, UK Joined February 2018-
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Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find 👉169 loci associated with cytokine levels 👉 promising drug targets for immune-mediated diseases Check out for more: medrxiv.org/content/10.110…
Really pleased to see our paper published in @eBioMedicine this week. We found that weight loss in people recently diagnosed with type 2 diabetes altered levels of cancer-related proteins in blood🩸. …w-sciencedirect-com.bris.idm.oclc.org/science/articl…
Thrilled to be part of the team making this data available to the UK Biobank research community. Our initial look at the data here and I am looking forwards to all the amazing discoveries this resource will enable. medrxiv.org/content/10.110…
Join our industry session at #ASHG2023: past, present and future of the application of genetics and genomics to drug discovery and development. Including geneticists in pharma @dermitzakis, @markmccarthyoxf @SlavePetrovski @JoHowson @melrose4747
Delighted to announce these long term career opportunities in human genetics research in a very exciting time for the field. The posts combine the advantages of working in academia & industry. Happy to discuss informally at [email protected] jobs.unige.ch/www/wd_portal.…
🤩 Excited to share a pre-print where we find a plausible mediator of the unexplained protective effect that childhood adiposity has on breast cancer risk – mammographic density! Using Mendelian randomization and mediation analysis, we showed that it mediates 56% of the effect.
🤩 Excited to share a pre-print where we find a plausible mediator of the unexplained protective effect that childhood adiposity has on breast cancer risk – mammographic density! Using Mendelian randomization and mediation analysis, we showed that it mediates 56% of the effect.
Full summary statistics for our UKB-PPP GWAS of 1,463 circulating proteins are now available at synapse.org/#!Synapse:syn5… This includes full cohort (n=52,363), discovery (n=34,557), & African ancestry (n=931) analyses. More subpopulations (AMR, CSA, MID, EAS) available next week.
Applying a lifecourse Mendelian randomization approach to family history data recapitulates evidence of time-varying effects of childhood adiposity on disease endpoints. Many thanks collaborators @HelenaUrquijo @mvholmes @mendel_random 🍻🥳🙏
Applying a lifecourse Mendelian randomization approach to family history data recapitulates evidence of time-varying effects of childhood adiposity on disease endpoints. Many thanks collaborators @HelenaUrquijo @mvholmes @mendel_random 🍻🥳🙏 https://t.co/cu9BEl8Mrf
Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes @AJHGNews article @GeneticsSociety @Claire_Prince_ @iTomRichardson hubs.li/Q01L6xt60
New paper out with fantastic colleagues @StefanStender & @mendel_random published in the @IntJEpidemiol academic.oup.com/ije/advance-ar… 🥳. We evaluated the effects of genetic variants and risk scores on biomarkers for fatty liver disease during the early stages of life using @CO90s data
Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study dlvr.it/SnTkzw
We have an exciting PhD opportunity available at @GSK with colleagues from @mrc_ieu. Come and develop novel methods to enhance drug development at the interface of industry and academia 😊 (with excellent travel/training awards and generous stipend!)
PhD STUDENTSHIP OPPORTUNITY!!! Come and work with us in the sunny south west. Interested in data, genetics, diabetes, pregnancy? Want great support, mentorship and training? Apply *by 31st March*: tinyurl.com/yckreunb @ExeterBRC @InesBarroso4 @ExeTeamBW
We have a few exciting paid Summer Internship opportunities in the Genomic Sciences group at GSK! Check out this one on solving human genetics questions in industry and working with the talented Rajashree Mishra: lnkd.in/ef79_hkm #hiring #intern #genetics #GSK
Now published in @BMCMedicine! bmcmedicine.biomedcentral.com/articles/10.11… Thanks again to @iTomRichardson @N_Murphy @EmmaEVincent @joshuaa_bell @ECSanderson @NeliMUlrich @nic_timpson @mendel_random @IARCWHO @BrisCancerEpi @mrc_ieu @WCRF_UK and many others
Congrats to brilliant PhD student @sifang1678 on her latest paper using Mendelian randomization to evaluate the effects of lipid lowering drug targets on risk of prostate cancer 🥳🥳🥳 thx so much to our co-authors @jamesyrmsk @dpsg108 @caroline_bull @mendel_random @tomrgaunt
Congrats to brilliant PhD student @sifang1678 on her latest paper using Mendelian randomization to evaluate the effects of lipid lowering drug targets on risk of prostate cancer 🥳🥳🥳 thx so much to our co-authors @jamesyrmsk @dpsg108 @caroline_bull @mendel_random @tomrgaunt
Job opportunity for genetic epidemiologist in Bristol - closing 4th Dec
Job opportunity for genetic epidemiologist in Bristol - closing 4th Dec
We have a bioinformatics research associate position at @ExeterMed to work on a collaborative project exploring epigenetic variation in Alzheimer's disease funded by @The_MRC. Link: tinyurl.com/yc7rzpwx. Please RT this threat and pass on to anyone who might be interested.
Veera Rajagopal @doctorveera
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64 Followers 414 Following "Unless you ran a randomized trial, potential confounders should keep you up at night" - Jeff LeekSantiago Prieto @SantiagoPM50
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2K Followers 630 Following Statistical Geneticist, Group leader at University of Lausanne/Unisante, father, climber, runnerLucy Goudswaard @lucygoudswaard
288 Followers 361 Following Senior Research Associate at the University of Bristol. My research interests include myeloma, obesity, proteomics and long covid.MRC IEU @mrc_ieu
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29K Followers 1K Following A clinician scientist at LTRI @sinaihealth @uoft @uoftmedicine who studies peptide hormones, GLP-1, diabetes, obesity and the gut endocrine system 🇨🇦🇮🇱george davey smith @mendel_random
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285 Followers 285 Following Senior Research Fellow in the MRC Integrative Epidemiology Unit, University of Bristol, UK.Kurt Taylor @KurtSci1994
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55 Followers 181 Following PhD student | Institute for Stroke and Dementia Research (ISD), Georgakis Lab, Munich #machinelearning #computervision #geneticsAmy Packer @A_Packer
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149 Followers 570 Following European Mathematical Genetics Meeting 2024 will be held 3-4 April at the Institute of Science and Technology AustriaSeth Sharp @SethASharp
436 Followers 1K Following Postdoc in the Translational Genomics of Diabetes Lab working on GWAS, function and polygenic risk. @StanfordMed formerly @ExeterMed @turinginstProject Football @ProjectFootball
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690 Followers 830 Following Professor of Human Genetics, University of Exeter, researching the genetics of female reproductive ageing.Dr Detelina Grozeva @DetelinaGrozeva
120 Followers 254 Following Statistician | Former geneticist | Clinical Trials | Genetics | Mental health disorders | @CTRCardiffUni | previously @Cambridge_UniPaul Naish @PaulNaish78
23K Followers 23K Following Global Head of Portfolio @ Taylor & Francis #Mathematics #Statistics #DataScience #HistSci #STS #scicomm. Fan of: 🐕🐈🐿🦔🍪☀️🍦Views = mine.Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find 👉169 loci associated with cytokine levels 👉 promising drug targets for immune-mediated diseases Check out for more: medrxiv.org/content/10.110…
Beyond excited to have accepted a faculty position as Lecturer in Health Data Science at Exeter starting in August. The genetics world has been incredibly welcoming to a naive mathematician, and I hope to return the favour! Watch this space… @ExeterBRC @uniofexeHLS
Friday pm random thought. I want a full omics work up of Jimmy Anderson's left knee. Nearly 42 y.o., he has put 7x his body weight through it nearly 40,000 times. To increase the sample size I would add Roger Federer's right shoulder but otherwise N is going to be small.
@ksuhre Do you think that there is the potential for introduction of collider bias using such ratios? See here for a long read: biorxiv.org/content/10.110… @syfi_24
Thrilled to be part of the team making this data available to the UK Biobank research community. Our initial look at the data here and I am looking forwards to all the amazing discoveries this resource will enable. medrxiv.org/content/10.110…
@iTomRichardson Ah, the first half was good, you really pulled away in the second half. We have away too many penalties. Was absolutely bloody freezing. I had 5 layers on!
Our paper is out in the #EuropeanJournalofNutrition! We found #adiposity may not be the only factor responsible for the associations between #UPFs and some upper-aerodigestive tract #cancers 🍔🍟🥤⤵️ doi.org/10.1007/s00394…
Another exciting whole genome association analysis paper from team @ExeterBRC using @uk_biobank data. We identify some of the first rare non-coding genetic aggregates, associated with height, which we replicated using @AllofUsResearch and #TOPMed
Whole genome association testing in 333,100 individuals across three biobanks identifies rare non-coding single variant and genomic aggregate associations with height biorxiv.org/cgi/content/sh… #bioRxiv
So this happened 🤝🔥 World highly cited since 2019 in Psychiatry/ psychology @KingsIoPPN @ClarivateAG ow.ly/4kt050Q7M15 Thanks for all friends @DavyVancampfort @PhysMentManc @PhilWardAu @FGaughran @simon_rosenbaum + many others
1. Most successful GWAS of fracture done to date just out in @NatureGenet Claes Ohlsson and colleagues found so many loci not by simply adding more cases, but refining case definition to include only forearm fractures. nature.com/articles/s4158…
Beautiful autumn colours @WestonbirtArb
Join our industry session at #ASHG2023: past, present and future of the application of genetics and genomics to drug discovery and development. Including geneticists in pharma @dermitzakis, @markmccarthyoxf @SlavePetrovski @JoHowson @melrose4747
A preprint from our team showing that PRS can be used to identifying individuals with undiagnosed disease
A polygenic risk score identifies undiagnosed cases of diabetes medrxiv.org/cgi/content/sh… #medRxiv
Sometimes splicing of proteins can more precisely identify mechanisms using #MendelianRandomization Here we identified several splice-isoforms of proteins that lead to severe COVID-19. DPP9 is a cool story. nature.com/articles/s4146…
Delighted to announce these long term career opportunities in human genetics research in a very exciting time for the field. The posts combine the advantages of working in academia & industry. Happy to discuss informally at [email protected] jobs.unige.ch/www/wd_portal.…
🤩 Excited to share a pre-print where we find a plausible mediator of the unexplained protective effect that childhood adiposity has on breast cancer risk – mammographic density! Using Mendelian randomization and mediation analysis, we showed that it mediates 56% of the effect.
The mediating role of mammographic density in the protective effect of early-life adiposity on breast cancer risk: a multivariable Mendelian randomization study medrxiv.org/cgi/content/sh… #medRxiv