parth @liminalbits

Synthetic compounds engineered to replicate the dual antioxidant activity of SOD and, in some cases, catalase. Manganese salen complexes like EUK-134, EUK-189, and EUK-207 showed remarkable effects in vivo: extending C. elegans lifespan, preserving cognitive function in aged…

A rapamycin derivative originally developed as an immunosuppressant, later tested for aging. In elderly humans, short-term low-dose RAD001 improved immune function and vaccine response, suggesting a partial rejuvenation of immune resilience. In animal models, it also enhanced…

Marc Andreessen explains why the “curse of the entrepreneur” is being too early “My experience is the great founders almost always feel like they’re too late, and you’re almost always too early.” The reason is because the idea seems obvious to the founder: “You’ve got some…

A DMAE ester once tested as an anti-aging drug. In senile guinea pigs, chronic Centrophenoxine reduced neuronal lipofuscin (“age pigment”) across multiple brain regions. nature.com/articles/21031… Unlike simple cholinergics, it was pursued for membrane turnover and pigment…

Sizes in perspective..

A nitrone spin trap explored as an in-vivo free-radical scavenger. In aged mice, PBN in drinking water extended both mean and maximum lifespan, with physiologic readouts suggesting improved metabolic efficiency. academic.oup.com/bbb/article/62… Unlike dietary antioxidants, PBN traps…

A spherical carbon nanomolecule that briefly shook aging research in 2012. In a Paris rat study, C60 in olive oil nearly doubled lifespan (22 → 42 months) while sharply reducing liver fibrosis and age-related inflammation. The proposed mechanism: superoxide scavenging at the…

Got peptides? From fat loss to longevity, a growing number of techies are injecting Chinese peptides for life upgrades. At one SF startup, they are the latest free perk. 📝: @AlmostZara sfstandard.com/2025/09/14/eve…

A selective MAO-B inhibitor that once showed genuine longevity signals. In aging male rats, chronic low-dose deprenyl pushed average lifespan from ~147 to ~192 weeks and preserved sexual/locomotor activity alongside dopaminergic function. sciencedirect.com/science/articl… Unlike…

A mitochondria targeted antioxidant designed to accumulate inside mitochondria via a triphenylphosphonium cation. In mtDNA mutator mice, SkQ1 extended mean lifespan by ~16% (277 → 321 days) and improved median survival, mobility, appearance, and tissue health.…

A core TCA cycle intermediate that once drew attention as a metabolic and longevity enhancer. In C. elegans, OAA supplementation extended median lifespan by ~25% and maximal lifespan by ~13%, requiring AMPK (aak-2) and FOXO/DAF-16 — the same pathways activated by calorie…

💊 GLP-1 therapies are evolving fast. From weight loss to sleep apnea, CV disease & even Alzheimer’s — new dual/triple agonists and antibody fusions expand the field. What’s next? Efficacy, access & long-term safety are key. @JAMA_current jamanetwork.com/journals/jama/… #GLP1…

An indazole-3-carboxylic acid derivative once tested as an “energy-blocking” cancer drug. Lonidamine inhibits mitochondrial-bound hexokinase II and the mitochondrial pyruvate carrier, disrupting both glycolysis and respiration. In tumors, it depletes ATP, acidifies the…

An anti-ischemic “metabolic modulator” that partially inhibits mitochondrial long-chain 3-ketoacyl-CoA thiolase (β-oxidation). In myocardium, TMZ reduces fatty-acid oxidation and shifts fuel use toward glucose, improving ATP/O₂ efficiency under ischemia (Randle cycle relief).…

A glucose analog that halts glycolysis by stalling at the hexokinase step. First tested in oncology to starve glycolysis-dependent tumors (Warburg effect), then later investigated in viral infections — including COVID-19 in India. In a Phase II trial (n=110), patients on 2-DG +…

An irreversible inhibitor of CPT-1, the mitochondrial gatekeeper for long-chain fatty acid oxidation. In heart failure studies, Etomoxir shifted cardiac metabolism toward glucose oxidation, improving efficiency and cardiac output in the short term. The ERGO trial (Clinical…

A complex of low-molecular-weight peptides extracted from bovine cerebral cortex, Cortexin has been used in Russian neurology for decades. Mechanistically, Cortexin inhibits caspase-8 (apoptotic trigger), modulates neuroinflammation, and stabilizes cytoskeletal + energy…

A short tripeptide from pineal research; acts as a genomic/epigenetic modulator with neuroprotective effects. In cell and mouse Alzheimer’s models, EDR helped preserve dendritic spines, supported neuroplasticity, and reduced stress-driven apoptosis. Mechanistically, evidence…

An endogenous tetrapeptide generated from thymosin-β4, Ac-SDKP is a potent anti-fibrotic + pro-angiogenic modulator. In vivo, chronic Ac-SDKP dosing prevented myocardial macrophage infiltration and collagen build-up, preserving cardiac function in hypertensive/ALDO-salt models.…

Identified in 2019 from a long noncoding RNA, Mm47 is a 47-aa micropeptide that localizes to mitochondria in macrophages. Deletion of Mm47 in mouse macrophages specifically suppressed NLRP3-inflammasome activation without affecting other inflammasomes (AIM2, NLRC4):…