parth @liminalbits

A short tripeptide from pineal research; acts as a genomic/epigenetic modulator with neuroprotective effects. In cell and mouse Alzheimer’s models, EDR helped preserve dendritic spines, supported neuroplasticity, and reduced stress-driven apoptosis. Mechanistically, evidence…

An endogenous tetrapeptide generated from thymosin-β4, Ac-SDKP is a potent anti-fibrotic + pro-angiogenic modulator. In vivo, chronic Ac-SDKP dosing prevented myocardial macrophage infiltration and collagen build-up, preserving cardiac function in hypertensive/ALDO-salt models.…

Identified in 2019 from a long noncoding RNA, Mm47 is a 47-aa micropeptide that localizes to mitochondria in macrophages. Deletion of Mm47 in mouse macrophages specifically suppressed NLRP3-inflammasome activation without affecting other inflammasomes (AIM2, NLRC4):…

Screen-born UPR modulator that elevates p-eIF2α and tweaks osteoblast/osteoclast balance. Acts upstream of ER-stress–autophagy to steady bone turnover. In OVX mice, it preserved BMD and bone volume while suppressing osteoclastogenesis (Cell Death & Disease 2019):…

Encoded by an alternative reading frame within the mitochondrial CYTB gene, this 187-amino-acid peptide emerged as a regulator of early mammalian development. Overexpression of CYTB-187AA in mice disrupted normal embryogenesis, indicating its powerful developmental role beyond…

The guy who makes sure your 'research use' is safe. ifykyk youtu.be/shgk3-u51Ys?si…

Encoded by the lncRNA 1810058I24Rik, Stmp1 is a 47-aa micropeptide localized to mitochondrial membranes in retinal cells. In mouse models of retinal ischemia–reperfusion (IR) injury, knockout of Stmp1 preserved retinal ganglion cells and suppressed microglial activation and…

Gamitrinib is a mitochondria-targeted HSP90 inhibitor designed to disrupt tumor-cell energy infrastructure. It induces PINK1/Parkin-mediated mitophagy by inhibiting TRAP1, leading to mitochondrial protein misfolding and autophagic clearance: oncotarget.com/article/22287/… Unlike…

Mensacarcin is a polyketide metabolite isolated from Streptomyces bottropensis, discovered for its cytotoxic effects on melanoma cells. The molecule localizes to mitochondria within 20 minutes and induces ROS-mediated apoptosis in BRAF-mutant melanoma lines (SK-Mel-28,…

Whenever I do a reference call on a founder to a Big tech company and the former manager says "He/She was difficult to work with and always did things differently than I asked" I smile and check the reference box.

Nabeel Hyatt @nabeel

2 weeks ago

Whenever I do a reference call on a founder to a Big tech company and the former manager says "He/She was difficult to work with and always did things differently than I asked" I smile and check the reference box.

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Discovered in Japan to blunt ER-stress and protect mitochondria after ischemia. Targets valosin-containing protein ATPase to prevent stress-death cascades in neurons. First-in-human CRAO trial: intravitreal KUS121 improved visual acuity; 78% reached ≥0.05 at 12 weeks…

Discovered in 2018 from a uORF upstream of the MIEF1 gene. Localizes to the mitochondrial matrix and binds the mitoribosome. Overexpression increases mt-encoded protein synthesis; knockdown reduces it: pmc.ncbi.nlm.nih.gov/articles/PMC64… Unlike CoQ10 regimens downstream, MIEF1-MP acts at…

Developed in Japan as a small-molecule neuroprotectant. Blocks endoplasmic-reticulum stress pathways and induces VGF expression. In SOD1 ALS mouse and rat models, treatment delayed disease onset and extended survival (PLoS One 2010): pubmed.ncbi.nlm.nih.gov/21151573/ In vitro, SUN…

Born in Chinese clinics, later re-examined as a mitochondrial protector. Boosts TFAM, stabilizes mtDNA, and reduces neuronal apoptosis under injury. In rat surgical brain injury, it preserved mitochondrial function and cut cell death: pmc.ncbi.nlm.nih.gov/articles/PMC10… Unlike high-dose…

Adenosine analog turned AMPK agonist; designed decades ago, then forgotten outside labs. Switches on oxidative genes in muscle—an exercise mimetic pathway. Sedentary mice ran 44% farther after 4 weeks of AICAR (Cell 2008): cell.com/cell/pdf/S0092… Unlike stimulants like…

Longevity gene therapy paper retracted. First retraction for George Church. Situation involved BioViva, co. headed by unlikely longevity figure Liz Parrish. Best quote from co-author: “I have retired and I am in Greenland. I do not have to talk to you.” retractionwatch.com/2025/08/13/geo…

Originated in Hungary to counter metabolic stress and membrane fragility. Co-induces HSP70 and stabilizes mitochondrial function via lipid-raft remodeling. Randomized double-blind trial showed improved insulin sensitivity vs placebo in insulin-resistant adults:…

Pandemics will end when deployment outruns mutation.

A mitochondrial-targeted segment from the Borna disease virus (BDV) X protein, discovered for its neuroprotective properties. In a Parkinson’s mouse model, intranasal delivery of the 29-AA C-terminal X protein fragment preserved dopaminergic axons and reduced oxidative damage:…

Hidden in LINC RNA, Slitharin is a 24-aa micropeptide found in cardiac stromal cells. Preclinical models show Slitharin protects cardiomyocytes from hypoxia and reduces infarct size in rat myocardial infarction: pubmed.ncbi.nlm.nih.gov/38444254/ Unlike systemic anti-inflammatories,…