Pietro Picconi @pietro_picc
Claiming to be a #Medicinal Chemist, ex #MSCA fellow, actually research scientist. tweets express my own opinions. Love swimming and running Joined March 2018-
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Buon #PrimoMaggio a tutti! Un buon momento per ripercorrere come si siano evoluti i salari medi in Europa negli ultimi trent'anni. 🇮🇪 Irlanda +74% 🇫🇷 Francia +33% 🇩🇪 Germania +30% 🇪🇸 Spagna +4% 🇮🇹 Italia -1% 🥲
Finally I read this viewpoint in @ACSMedChemLett. I do not disagree that successfully crafting a total synthesis is a good medicinal chemisty training ground, but how the over-competitive culture in total synthesis groups has stiffled chemistry innovation can't be ignored. (1/x)
Pretty sure I’m going to sleep okay tonight despite this clearly career-ending McKinsey white paper. For those who need to hear it again: generating “potential molecules” is not the rate-limiting step in drug discovery.
Pretty sure I’m going to sleep okay tonight despite this clearly career-ending McKinsey white paper. For those who need to hear it again: generating “potential molecules” is not the rate-limiting step in drug discovery.
Chemistry Christmas Tree complete with reindeer and snowman at @kclchemistry Teaching Lab. 😂 Post your innovative Christmas tree ideas. #chemistry
Another paper from @MRahmanLab in collaboration with @HealthcareUKHSA and @HindCharlie on broad spectrum pyrrolobenzodiazepine class of antibiotics. @pietro_picc led the study during his time with us. #amr mdpi.com/2079-6382/11/1…
94 year old ex army Tory party member father just said he’d now vote Labour. Pre whisky.
Statue su Mussolini, immagini del Ventennio, foto del colonialismo fascista, camicie nere. Da domani Ignazio Benito La Russa sarà presidente del Senato, la seconda carica più importante. E a proclamarlo sarà Liliana Segre, che del fascismo fu vittima. Vergogna, Giorgia Meloni
Excited to see this finally out: SMARCA2 isoform-selective (90% identical bromodomain sequence) and orally bioavailable PROTAC degrader ACBI2 achieves efficacy in SMARCA4-deficient tumour models in vivo. Great teamwork @UoDLifeSciences #CeTPD @Boehringer @farnaby84 @ChemHaWei
Congrats to my former @Harvard bandmate @CarolynBertozzi on her @NobelPrize in chemistry! We won the Ivy League Battle of the Bands in 1986 with our rockin’ group ‘Bored Of Education’, with her on keyboards & me in spandex. news.stanford.edu/2022/10/05/car…
News and Views in NSMB! Four new structures of the SHOC2-SMP-PP1C complex help to rationalize multiple RASopathy mutations and suggest models to explain the selection of the RAF substrate. nature.com/articles/s4159…
Med chem early career tip: drug discovery is its own skill. A bit of chemistry, biology, DMPK, toxicology — but none of those things exactly. First industry job, you won’t know it. Swallow the Dunning-Kruger pill early. If you don’t feel humbled by the task, something’s missing.
How are six membered rings drawn in the chemical community? Here is my strategy. Please reply with yours!
Queue is such a great word. The actual important letter, and then four more silently waiting behind it in a line.
A few weeks ago, I was asked what kinds of questions I consider for career self-reflection — a process I recommend doing at least once a year. Below is a non-exhaustive set of questions. Feel free to add more reflection questions that have helped you in the comments! 1/11
È morto Mikhail Gorbachev!
Advances in covalent drug discovery go.nature.com/3R8Wz85 A new review by @DanNomura and colleagues highlighting covalent drug discovery successes such as BTK, EGFR and KRAS inhibitors, lessons learned and the evolving toolbox for the field, such as chemoproteomics platforms
just to be clear... chemistryworld.com/opinion/why-al…

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Chinese Chemical Lett... @ChinChemLett
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Anthony Rullo: chemic... @LabRullo
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