Anthony Rullo: chemically modulating proximity @LabRullo
Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology rullolab.com Joined June 2019-
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Anthony Rullo: chemically modulating proximity retweeted
The fusion of intrinsically disordered regions to CARs enhances CAR-T signaling by inducing CAR condensation and enhances CAR sensitivity to low-antigen-expressing cancer cells nature.com/articles/s4158…
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Anthony Rullo: chemically modulating proximity retweeted
It has been a particular joy to develop the family of tr-FPs with my group. All authors are greatly appreciated, and we thank @CellCellPress for publishing this work. Plasmids are available via WekwikGene, and we hope you enjoy imaging in the temporal and spectral domains!
It has been a particular joy to develop the family of tr-FPs with my group. All authors are greatly appreciated, and we thank @CellCellPress for publishing this work. Plasmids are available via WekwikGene, and we hope you enjoy imaging in the temporal and spectral domains!
Anthony Rullo: chemically modulating proximity retweeted
Congrats to my graduate student Dave Leace and team on the new paper! They discovered a ligand-induced protein tethering (LIPT) molecular glue mechanism — revealing new PPIs, altered protein localization, and disrupted cancer metabolism. pubs.acs.org/doi/full/10.10…
Anthony Rullo: chemically modulating proximity retweeted
Huntington's disease has been successfully treated for the first time, doctors tell BBC bbc.in/46jnMiX
Anthony Rullo: chemically modulating proximity retweeted
kendrick v drake for physical organic chemists
Anthony Rullo: chemically modulating proximity retweeted
Rational design of the linkers in targeting chimeras - now published in Chemical Science pubs.rsc.org/en/content/art…
Anthony Rullo: chemically modulating proximity retweeted
Hydration (H2O and D2O) Dictates the Stabilities and Conformational Entropy of Transthyretin Tetramers | Journal of the American Chemical Society @TAMUChemistry @TAMU pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Design, Synthesis, and Biological Evaluation of Arginine N-Glycosylation Stapled Peptides with Potent Antitumor Activity In Vivo | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…
Anthony Rullo: chemically modulating proximity retweeted
Our group's newest preprint! @EvelineTiekink and @YumanHordijk reveal that Lewis acids prefer σ-binding to lone pairs rather than π-binding to double bonds, with implications for chemical bonding and reactivity! Great work by the team! 🔍💻🧪 doi.org/10.26434/chemr…
Anthony Rullo: chemically modulating proximity retweeted
Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display | Journal of the American Chemical Society @UChicago @UChiChemistry @czbiohub pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
New paper in JACS: we show covalent chemistry isn’t just for proteins — it can make selective RNA-targeting small molecules. Found that 3-chloropivalamides crosslink RNA and used it to design a covalent binder of r(CUG) repeats in DM1. 🔗 doi.org/10.1021/jacs.5…
Anthony Rullo: chemically modulating proximity retweeted
Thiocrown Ether: Reversing SN1 to SN2 Pathways in 1,2-cis Phosphoryl Glycosylation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Catalytic Consequences of Pore Structure, Nodal Identity, and Coordination Environment on Styrene Oxidation by Hydrogen Peroxide over Fe MOFs pubs.acs.org/doi/10.1021/ja… @J_A_C_S @isciverse #Chemistry #chemed #scicomm #news #Technology #Tech #TIC2025 #research #science…
The field critically needs more work like this that aims to help understand mechanism , the how and the why. New Tech is great but less impactful without mechanistic analysis
The field critically needs more work like this that aims to help understand mechanism , the how and the why. New Tech is great but less impactful without mechanistic analysis
Anthony Rullo: chemically modulating proximity retweeted
The benefits of disorder The presence of an intrinsically disordered region in a transcription factor enhances both target binding and search efficiency. elifesciences.org/reviewed-prepr…
Anthony Rullo: chemically modulating proximity retweeted
Automated Reactivity Prediction of Complex Molecules and Its Application to Total Synthesis of Ageliferin | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Cell Therapy innovators, join us for an exciting webinar on Rational CAR design: integrating affinity and tonic signaling with Dr. Markus Barden (Hinrich Abken Lab, Regensburg).
Anthony Rullo: chemically modulating proximity retweeted
Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s4158…
pubs.acs.org/doi/10.1021/ac… Very proud of this effort by the group! Here we explore how and why the reaction kinetics of covalent drugs can be enhanced by the target binding site itself and reveal enhancement is likely coupled to electrophile reaction mechanism.
Anthony Rullo: chemically modulating proximity retweeted
Development of Cyclooctyne-Nitrone Based Click Release Chemistry for Bioorthogonal Prodrug Activation both In Vitro and In Vivo pubs.acs.org/doi/10.1021/ja… @J_A_C_S @isciverse #Chemistry #chemed #scicomm #news #Technology #Tech #TIC2025 #research #science #AcademicTwitter
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