theparkerlab @theparkerlab
The Parker lab at U. of Michigan theparkerlab.org Ann Arbor, MI Joined January 2019-
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Awesome work! Congrats!
I'm looking to hire a lab manager! careers.chop.edu/us/en/job/1008…
Should be fun!
What's the best way to handle single-cell datasets with multiple epigenome features per cell? Could treat them as separate peak sets. But @cgao90 developed a better way: modeling the data as a multi-channel sequential signal over genome positions.🧵 biorxiv.org/content/10.110…
The @SoleimanpourLab at @umichmedicine is a fantastic place to do high-quality science. Go @SoleimanpourLab go!
The @SoleimanpourLab at @umichmedicine is a fantastic place to do high-quality science. Go @SoleimanpourLab go!
Thanks @ade__lady ! Please consider joining our team - we'd love to hear from you!
Thanks @ade__lady ! Please consider joining our team - we'd love to hear from you!
New NIH-supported research takes large datasets and analyses of pancreatic tissues to uncover some of the mechanisms that lead to #Type2Diabetes. Learn more on the #NIH Director’s Blog: go.nih.gov/yBIsume
Fantastic work! It's been a privilege to be on Steve's committee. What a rock-star scientist and overall awesome person. Congrats, Steve!
Fantastic work! It's been a privilege to be on Steve's committee. What a rock-star scientist and overall awesome person. Congrats, Steve!
A new study in @Nature from U-M (@theparkerlab) and @VUMChealth links gene network and pancreatic beta cell defects to type 2 diabetes michmed.org/mQG45
Comprehensive @Nature study of pancreas cells + population-scale genetics links #betacell defects and regulatory gene network to Type 2 #diabetes, find @vumcdiabetes, @powersac_TN, @VUMCgenetics + @UMichMedScience's @theparkerlab. news.vumc.org/2023/12/04/stu…
Thrilled our work is out is @Nature! A decade of work with incredible collaborators and a great team working to decipher disease driving mechanisms in type 2 diabetes. nature.com/articles/s4158… 1/6
New story from my other day job! Led by @jennimac13, we describe our novel receivership model (led by adult endo) for young adults with T1D to transition from peds to adult care. Excited that receivership can set a new standard for T1D transition! sciencedirect.com/science/articl…
On Sat, PB1089 from postdoc @ade__lady (& @theparkerlab) uses a modular MPRA to interrogate enhancer-promoter context and cell type influences on regulatory action
I am excited to share our preprint describing a collaborative effort to identify conditionally distinct signals in the largest adipose eQTL dataset to date (AdipoExpress)! @kerrin_small, @klmohlke, Laura Scott, @Julia_Moustafa, @mikelove, and others. 1/8 biorxiv.org/content/10.110…
Happy to report the publication of my first senior author paper after peer-review. An amazing collaboration with @dermitzakis, @arnsbr and @DIRECTdiabetes. nature.com/articles/s4146… And here a thread on the main findings and updates from the #preprint: 👇
An important update on the @NIH Diabetic Foot Consortium with @NIDDKgov's Teresa Jones, MD, with our own & @ADA_DiabetesPro President Rodica Pop-Busui, MD, PhD #ADA2023
Outstanding talk by Yasminye Pettway in a session on insulin secretion! Powers and Brissova Research Group @VanderbiltMSTP #ADA2023
Excited to be a symposium speaker at #ADA2023 with @InesBarroso4 and @AlisaManningPhD to to talk about multi-ancestry GWAS and PRS in T2D and related traits!! Come join us at 4:30pm in ballroom 6AB!
We are pleased to share that Dr. Daniel Michele (@MicheleLabUM) has been formally appointed as Chair of @UMPhysiology. Dan has been serving as interim chair for almost two years and will now continue to lead the department as chair. mmheadlines.org/2023/05/daniel…
Anna Gloyn @annagloyn
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6K Followers 247 Following GWAS whisperer 'Nothing in biology makes sense except in the light of evolution' -Dobzhansky DMs open Executive Director, Integrative Biology @PfizerMichael Love @mikelove
18K Followers 5K Following I'm not on twitter anymore, find my on Bluesky or MastodonMichael Hoffman @mich.. @michaelhoffman
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2K Followers 2K Following Assistant professor @UBC in the Faculty of Pharmaceutical Sciences. Interested in diabetes, developmental biology, and genetics.Xinjun Zhang @Xinjun90
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932 Followers 1K Following Ruth L. Kirschstein NRSA Fellow| PhD Candidate at Vanderbilt |Developmental Physiology-fan| Magical Black Girl| Clemson '18 | Ideas are my own.the(sugar)science @thesugarscience
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782 Followers 235 Following Professor, Center for Molecular Medicine and Genetics, Wayne State University. Human and Population Genetics and Genomics.Dan Michele @MicheleLabUM
2K Followers 1K Following Professor and Chair, Department of Molecular & Integrative Physiology University of Michigan @UMPhysiology @umichCVC @umich https://t.co/IUbexuCzm4Mete Civelek @mete_civelek
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3 Followers 52 Following Learning and engaging with others invested in the complex world of diabetes and diabetes-related research.Erik Marchant @ErikDMarchant
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508 Followers 1K Following still enjoying heavy metal and figuring out how beta cells work #hypersecretion thank you funders @congenitalhi @DiabetesRsrch @IUSweetTweets and islet donorsSachin Muralidharan @SachinMuralid15
215 Followers 328 Following Doctoral Student at @OtonkoskiL/@_DiegoBalboa_ lab. Interested in early pancreatic development, transcriptional regulation and single cell omics.Jinrong Hu @HJRBio
300 Followers 1K Following RA @RongLabOfficial /Bershadsky labs @MBIsg. Cardiomyocyte, yeast, ploidy, scaling, oocyte, formin, PPI. Views mine. Seeking meaning of life in science.Boomer Olsen @Boomer_Olsen
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165 Followers 2K Following Doç.Dr. Hacettepe Üniversitesi @hacettepe1967, Çocuk Sağlığı Enstitüsü, Çocuk Metabolizma Lab., || Alumnus: @UF, @ETHSheri @sagrill11
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607 Followers 404 Following Pharmacist-Scientist improving medication outcomes and disparities with #pharmacogenomics and #precisionmedicine @UMichPharmacyOmnia Reda @Omnia_Reda_
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152 Followers 252 Following Lead Bioinformatician @UMich | Ph.D. @IowaStateU | T2D/Placenta research 🧬🔢👩💻🎶📖Genome Research @genomeresearch
56K Followers 262 Following A leading peer-reviewed genomics journal. Mastadon: https://t.co/v31waKv6mB Bluesky: https://t.co/tjRPsmnyT5 Submit: https://t.co/6vTemDJxKGDr Kelly De Coteau @KDeCoteau1
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85 Followers 191 Following Sales professional working in #Genomics, #metabolomics and #precisionmedicine. All views my own.CJ Clay @CJClayUMCDI
29 Followers 154 Following Supporting the UM Caswell Diabetes Institute #CaswellDiabetes in its mission to advance research and care to improve patient outcomes #MichiganDiabetes #GOBLUENgozi D. Akingbesote @dumebiike
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4K Followers 763 Following Prof of Pediatrics & Genetics 🧬 - Translational Genomics of Diabetes Lab #diabetes, #genetics #islets #womeninStem #teamscienceAnshul Kundaje (anshu.. @anshulkundaje
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18K Followers 5K Following I'm not on twitter anymore, find my on Bluesky or MastodonMichael Hoffman @mich.. @michaelhoffman
23K Followers 7K Following Chair, Comp Bio & Medicine Program, Princess Margaret Cancer Centre. Assoc Prof, Med Biophysics & Comp Sci, University of Toronto. COI https://t.co/CvupKNIjZrMichael Eisen @mbeisen
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13K Followers 8K Following Physiologist, Mentor, Assoc. Director VCHRI, IPTN cofounder, exPharmaVP (NNRCO), Dad, Hub, HockeyGuy. Views≠employer's RT≠endorse he/him/ On all the sites.Nicole Krentz @nkrentz
2K Followers 2K Following Assistant professor @UBC in the Faculty of Pharmaceutical Sciences. Interested in diabetes, developmental biology, and genetics.Xinjun Zhang @Xinjun90
1K Followers 1K Following Assistant Professor at the University of Michigan. Popgen/Evolgen, archaic humans, machine learning etc. Traveler, amateur photographer, and life enthusiastBrooke N. Wolford, Ph.. @bnwolford
1K Followers 2K Following Statistical geneticist @NTNU. Marie Skłodowska-Curie Postdoc. Formerly @UMich, @genome_gov, @UNC & @NCSSM. more science | more empathy. she/her👩🏻💻🧬Mark Huising @HuisingLab
1K Followers 482 Following Prof@UCDavis, Islet researcher, teacher of physiology and immunology, runner, recovering volleyball player, dad. Concerned about climate. All views my own.Bhramar Mukherjee @BhramarBioStat
29K Followers 1K Following Researcher + educator with focus in precision and population health using #BigData. Chair @umichsph Biostatistics, Prof of Epidemiology, @UMRogelCancer. she/herEwan Birney @ewanbirney
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1K Followers 549 Following Computational Biologist, Associate Professor at U. MichiganManolis Kellis @manoliskellis
25K Followers 4K Following Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitutethe(sugar)science @thesugarscience
2K Followers 5K Following Connect with type 1 diabetes researchers👩🔬 globally 🌎 across disciplines 🔬 JOIN US: https://t.co/haCFqtt02X. Linktr: https://t.co/ftixFS73kaMegan Killian @megankillian
6K Followers 5K Following TT professor #tendonresearch @umichmedicine. Proud Michigander (👐). Steward of @killianlab 〽️. Views are mine. #prochoice #blm (she/her) #GoBlueMing "Tommy" Tang @tangming2005
31K Followers 2K Following Director of computational biology. On my way to helping 1 million people learn bioinformatics. Educator, Biotech, single cell. Also talks about leadership.Saori Sakaue @saorisakaue
899 Followers 315 Following MD/PhD, rheumatologist, studying computational biology @harvardmed with @soumya_boston. Seeking how much of our destiny can be explained by data and science.Marcin Cieslik @i000
220 Followers 1K FollowingTony Antonellis @SequenceMan
483 Followers 616 FollowingJasmine Luzum, PharmD.. @JasmineLuzum
607 Followers 404 Following Pharmacist-Scientist improving medication outcomes and disparities with #pharmacogenomics and #precisionmedicine @UMichPharmacyUMich ITS @umichTECH
7K Followers 1K Following Information & Technology Services supporting @UMich #LeadersAndBest with all their technology needs. #UMichTECH #MichiganIT @umichARCHa Vu @havu0201
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1K Followers 804 Following @MGHMedicine, @uvamedicine & @WestVirginiaU alum. Director, IU Center for Diabetes & Metabolic Diseases & @DeptVetAffairs physician. Views are my own.Eva Feldman, MD, PhD @EvaFeldmanMDPhD
1K Followers 333 Following @umichmedicine neurology, NeuroNetwork for Emerging Therapies, ALS Center of Excellence, Brain Health, Diabetes Complications-Views are my ownAaron Cox, Ph.D. @CoxAaronR
693 Followers 692 Following Assistant Professor at University of Texas Health Science Center; islet biologist with interests in obesity, metabolism, immunology.Jedidiah Carlson @JedMSP
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6 Followers 179 Following Say what you do, do what you say. Avid couponer at CVS. Nicolas Cage fan.Josh Weinstock @J__Stock
572 Followers 1K Following Research Scientist @JohnsHopkins. Excited about the mysteries in our genomes. #genetics #biostatisticsDr Kelly De Coteau @KDeCoteau1
103 Followers 262 Following Postdoc 👩🏽🔬| Regulatory genomics in Metabolic disease with the Cebola Lab, Imperial College London 🧬 | PhD in Vascular Science @ NHLI 🫀Ross Guarnera @cfDNA
85 Followers 191 Following Sales professional working in #Genomics, #metabolomics and #precisionmedicine. All views my own.Ngozi D. Akingbesote @dumebiike
498 Followers 312 Following 🇳🇬🇺🇸| I am the author of a future🔬Yale PhD Candidate in the PerryLab @Yale School of Medicine. #CancerMetabolism & #ExerciseFascinating @fasc1nate
3.3M Followers 2K Following Posting interesting science, gadgets, history, art, and more. Subscribe for in-depth posts. As an Amazon Associate I earn from qualifying purchases.Jason Stein @jsteinlab
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992 Followers 941 Following Interested in zebrafish, gene editing, and disease modeling. Opinions are my own and not the views of my employer.Peter Smibert @psmibert
2K Followers 1K Following Same handle on other site. Vice President, Biology @10xgenomics. Former @nygctech/@nygenome. Views my own 🇦🇺Jens Durruthy @JensDurruthy
882 Followers 1K Following Director, Product Management @10xgenomics •Focus on #SingleCell •Trilingual in English, German, Science. Views are my own and not those of my employer.David Davtian @DavidDavtian1
48 Followers 102 Following PhD student in Bioinformatics at the School of Médecine - Dundee. Working on type 2 diabetes and links with genetics and obesity.Steve Munger @stevemunger
2K Followers 2K Following Associate Professor at JAX. Hack scientist, accomplished home cook, world class contrarian. My views are my own. https://t.co/73gVCyQxwS He/himElise Flynn @EliseScience
331 Followers 605 Following Computational Biologist @ Patch Bio. regulatory DNA, RNA | gene therapy | synthetic biology My ''professional'' twitter account. She/her.ASHG @GeneticsSociety
52K Followers 323 Following The American Society of Human Genetics (ASHG) is the world's largest professional membership organization for human genetics & genomics specialists.Jeff Vierstra @jeffvierstra
924 Followers 272 Following Senior Investigator @ Altius Institute. Chromatin structure & function. Mountain shenanigans and skiing turns all year. 🇺🇸 🇨🇱Animate Your Science @Animate_Science
4K Followers 4K Following We empower scientists to change the world by communicating in an effective and accessible way.Santhi Ganesh @SanthiKGanesh
422 Followers 552 Following Physician-scientist, cardiovascular medicine and genetics @UMich #FMD #SCAD #Hypertension #CVDinWomenFatimata Sanogo @FSanogo_Epi
97 Followers 140 Following PhD Candidate- Epidemiology & yoga teachcer | Effective leader with excellent listening and speaking skills| Leading by inspiration English, French, Fulani.Dr. Elana J Fertig @FertigLab
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149 Followers 311 Following UMich BME '22 | Incoming UChicago GGSB Ph.D. Student | Complexity, Environmental Microbiology, Philosophy of ScienceJeffrey Chuang @jeffgenome
437 Followers 165 Following Computational biologist focused on cancer, image analysis, evolution, and biophysics. All opinions are my own.Trae Crowder @traecrowder
382K Followers 2K Following Comedian, renowned blood traitor, etc. The Liberal Redneck https://t.co/L53WJP0vNxCarlos Cruchaga @ccrugom
1K Followers 341 Following NeuroGenomics and Informatics Center Director. Washington University School of MedicineKatherine Gallagher @BTBKGMD
2K Followers 745 Following Vascular surgeon, mom, scientist, immunology enthusiast, former college athlete, sports mom for Eian and Riley GallagherSzerlip. https://t.co/0uMKV8PTrBKP Network @KPortalNetwork
137 Followers 102 Following The Knowledge Portal Network is an infrastructure that integrates, interprets, and presents human genetic data to spark insights into complex diseases.Jeffrey Mold @Jeff_Mold
3K Followers 2K Following American Scientist living in Sweden - Studying high risk/low reward curiosity-driven biology. All views are my own. I went to college.Impact Media lab @impactmedialab
2K Followers 957 Following Helping scientists share knowledge, build community, and create impact with their work. Media | Strategy | DesignRachel Reinert @RBReinertMDPhD
128 Followers 273 FollowingCongrats to Dr. Jordan Reed for her first first-author paper. Thanks also to @JohanBjorkegren and @novonordisk scientists led by Wen Ding. @LSAjournal @UVABME “Systems genetics analysis of human body fat distribution genes identifies adipocyte processes” life-science-alliance.org/content/7/7/e2…
Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2 dlvr.it/T6Kr1x
The whole body response to exercise training! First major release of NIH Common Fund MoTrPAC (Molecular Transducers of Physical Activity Consortium) data and collection of paper is out. nature.com/articles/s4158…
My functional validation of a causal variant at the FAIM2 obesity GWAS locus is out today in @CellGenomics! (1/4) cell.com/cell-genomics/…
Our paper just out in @CellGenomics addresses the childhood obesity FAIM2 locus. From her thesis work, Sheridan Littleton (@sciencesheri) reports its functional characterization in the challenging hypothalamic context - see details in her thread. @CHOP_Research @PennGenetics
My functional validation of a causal variant at the FAIM2 obesity GWAS locus is out today in @CellGenomics! (1/4) cell.com/cell-genomics/…
Buddy brought 14+ years of joy to our family but walked his last short walk yesterday. Always there when someone was down, and always up for an extra treat. If you need a Buddy in your life, I hope you find one like ours.
Ever wondered when you "scaled down" parameters in SLiM, what is being simulated is actually comparable to what is intended by the model? We got an answer for you!
Towards Simulation Optimization: An Examination of the Impact of Scaling on Coalescent and Forward Simulations biorxiv.org/cgi/content/sh… #biorxiv_evobio
Love seeing long winded rants against GWAS that could be summarized into a single tweet of "I just don't like the idea but have little ACTUAL justification for it"
Carlos Sainz just wanting to sing smooth operator
My academic mom a.k.a my PhD advisor, Dr. Tuteja, was promoted to be a full professor this week. She doesn't have a Twitter (or not one that I know of) so I need to tell the world on her behalf 🎉🎉🎉🤣 provost.iastate.edu/faculty-succes…
Excited to share with the single-cell community the most recent work of @tmontsay and @AEsteveCodina from @cnag_eu, something we think will be a game-changer in #scRNAseq quality control: biorxiv.org/content/10.110… @biorxivpreprint Get ready for the tweetorial! 1/10
@nmancuso_ @anshulkundaje @tuuliel_lab @Hakha_Most @sara_mostafavi @Luke__Ward Yes, I agree. I think this is also one of the reasons why in the @eQTLCatalogue we are seeing much less eQTL sharing between purified cell types and more between various bulk tissues. At least primary signals in bulk tissues are probably more enriched for promoter variants.
@kauralasoo @anshulkundaje @tuuliel_lab @Hakha_Most @sara_mostafavi @Luke__Ward For bulk rnaseq I can see this capturing promoter effects, but the mixture across cells will substantially deplete enhancer eqtls which are enriched for cell type/state. Personal experience says scRNA helps but still a ways to go
I'm not a big fan of productivity hacks, I think the best thing you can do it just sit down, focus, and work on your shit. But I've been doing something for a couple of years now that has been life changing for me as someone running a medium sized lab, here's a 🧵about it 1/
☹️Google Scholar is a great tool. But it doesn't show how papers are connected with each other. 😀Here's how to fast-track your literature review with a "visual search." And export your papers to Zotero, Mendeley, or EndNote. You can learn this workflow in 15 min:
It looks like three different groups have each sequenced ~1000 samples from the 1000 Genomes Project with nanopore long reads: medrxiv.org/content/10.110… medrxiv.org/content/10.110… biorxiv.org/content/10.110… Relation between the manuscript not clear to me.
Concluding the 2023-2024 University of Michigan's Department of Computational Medicine and Bioinformatics seminar series. Thanks to all speakers, hosts, and staff!