The Sharing Scientist @ScienceShared
Bringing you the most interesting & important science news that you need, summarised & sourced directly to your feed. Also will call out stuff others don't. Joined December 2010-
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The Sharing Scientist retweeted
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The Sharing Scientist retweeted
Target RNA recognition drives PIWI∗ complex assembly for transposon silencing cell.com/molecular-cell…
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Rethinking RNA-binding proteins: Riboregulation challenges prevailing views: Cell cell.com/cell/fulltext/…
The Sharing Scientist retweeted
1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
The Sharing Scientist retweeted
A new paper, in Nature Chemistry, proves that there are still tons of "basic" things to discover in biology. There is so much room at the bottom. TL;DR: Researchers discovered a new type of post-translational modification, called “oligophosphorylation.” Rather than being tagged…
The Sharing Scientist retweeted
A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a…
The Sharing Scientist retweeted
Ribosome density is often used as a surrogate for translation efficiency. However, this article suggests differences in translation elongation rates across mRNAs: ⬛️ Translation elongation rates vary up to ∼ 20-fold among transcripts. 🧵
The Sharing Scientist retweeted
Protein designers have long dreamed of building new enzymes from scratch. Unfortunately, enzymes are highly dynamic; they move around a lot and have intermediate states that are difficult to design computationally. But a recent paper from David Baker’s group at the Institute…
The Sharing Scientist retweeted
The heterogeneity of HeLa cell-lines undermines reproducibility. HeLa cells were obtained without informed consent. ==> Researchers should avoid using HeLa cells unless required by a special justification.
The Sharing Scientist retweeted
DNA copy number variation is strongly buffered at the protein level. The buffering is much stronger than at the RNA level.
The Sharing Scientist retweeted
Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease go.nature.com/4mwBvbr
The Sharing Scientist retweeted
For protein science/bioinformatics: MMseqs Diamond FoldSeek BioTite ColabFold BioPython pdb-tools Seqkit hh-suite IQ-Tree MAFFT TMAlign PyRosetta (Just released in 2024) DSSP BLAST ProteinMPNN RFDiff AlphaFold2 ESM BindCraft RDKit Boltz HMMER GROMACS Which others?
For protein science/bioinformatics: MMseqs Diamond FoldSeek BioTite ColabFold BioPython pdb-tools Seqkit hh-suite IQ-Tree MAFFT TMAlign PyRosetta (Just released in 2024) DSSP BLAST ProteinMPNN RFDiff AlphaFold2 ESM BindCraft RDKit Boltz HMMER GROMACS Which others?
The Sharing Scientist retweeted
GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion nature.com/articles/s4159…
The Sharing Scientist retweeted
Fantastic new paper by Reese Richardson et al. "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly." An enormous amount of work showing the extent of coordinated scientific fraud and involvement of some editors. pnas.org/doi/10.1073/pn…
The Sharing Scientist retweeted
Proteins are constantly moving, but our structures of them are static. Clare Sansom talks to the researchers using free-electron lasers to make time-resolved structures chemistryworld.com/features/seria…
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I have been thinking if there's any better way to specify amino-acid residues in ChimeraX without opening the sequence viewer, and I finally made it to this point! This feature is now aviailable in ChimeraX-CliX v0.2.3, so please give it a try! cxtoolshed.rbvi.ucsf.edu/apps/chimeraxc…
The Sharing Scientist retweeted
Diffusing Protein Binders to Intrinsically Disordered Proteins 🚀 New paper from David Baker!🚀 1. A groundbreaking study published in Nature demonstrates a novel method for designing protein binders that can target intrinsically disordered proteins (IDPs) and regions (IDRs)…
The Sharing Scientist retweeted
Potato evolved from tomato 9 million years ago. cell.com/cell/fulltext/… @NHM_London Sandra Knapp @UBC Loren H. Rieseberg @SCUCN Jianquan Liu #CAAS Sanwen Huang @CellCellPress
The Sharing Scientist retweeted
Translational traffic jam in aging brains | Science science.org/doi/10.1126/sc…
The Sharing Scientist retweeted
Are drug effects on mRNA & protein levels similar? Below are example dose-response curves of drug-induced changes in protein (blue) and mRNA (pink) abundance. 1/n
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