The Sharing Scientist @ScienceShared
Bringing you the most interesting & important science news that you need, summarised & sourced directly to your feed. Also will call out stuff others don't. Joined December 2010-
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Now online! Single-cell nascent transcription reveals sparse genome usage and plasticity dlvr.it/TNJwXP
We are proud to share a paradigm-shifting publication from Westlake University in the journal @ScienceMagazine . The study, led by Prof. Xiang-Dong Fu, reveals a fundamental mechanism of gene expression: how cells accurately identify correct splice sites during transcription.…
A big moment for biomedical research publishing: - HHMI preprint mandate. Starting January 1, 2026, Howard Hughes Medical Institute (HHMI) labs will be required to publish all original research articles that represent major contributions from their laboratories as both…
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️
Why has it taken over 50 years to publish a study that examined the total lifetime exposure to ‘safe’ glyphosate levels to which most people are subjected and find multiple types of cancer? regenerationinternational.org/2025/06/24/the…
This article suggests that TF binding is determined by the sum of multiple, overlapping binding sites. Thus, competition between paralogous TFs for shared high-affinity binding sites may be influences by flanking nucleotides from overlapping, lower-affinity binding sites. 🧵
Target RNA recognition drives PIWI∗ complex assembly for transposon silencing cell.com/molecular-cell…
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views: Cell cell.com/cell/fulltext/…
1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
A new paper, in Nature Chemistry, proves that there are still tons of "basic" things to discover in biology. There is so much room at the bottom. TL;DR: Researchers discovered a new type of post-translational modification, called “oligophosphorylation.” Rather than being tagged…
A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a…
Ribosome density is often used as a surrogate for translation efficiency. However, this article suggests differences in translation elongation rates across mRNAs: ⬛️ Translation elongation rates vary up to ∼ 20-fold among transcripts. 🧵
Protein designers have long dreamed of building new enzymes from scratch. Unfortunately, enzymes are highly dynamic; they move around a lot and have intermediate states that are difficult to design computationally. But a recent paper from David Baker’s group at the Institute…
The heterogeneity of HeLa cell-lines undermines reproducibility. HeLa cells were obtained without informed consent. ==> Researchers should avoid using HeLa cells unless required by a special justification.
DNA copy number variation is strongly buffered at the protein level. The buffering is much stronger than at the RNA level.
Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease go.nature.com/4mwBvbr
For protein science/bioinformatics: MMseqs Diamond FoldSeek BioTite ColabFold BioPython pdb-tools Seqkit hh-suite IQ-Tree MAFFT TMAlign PyRosetta (Just released in 2024) DSSP BLAST ProteinMPNN RFDiff AlphaFold2 ESM BindCraft RDKit Boltz HMMER GROMACS Which others?
For protein science/bioinformatics: MMseqs Diamond FoldSeek BioTite ColabFold BioPython pdb-tools Seqkit hh-suite IQ-Tree MAFFT TMAlign PyRosetta (Just released in 2024) DSSP BLAST ProteinMPNN RFDiff AlphaFold2 ESM BindCraft RDKit Boltz HMMER GROMACS Which others?
GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion nature.com/articles/s4159…

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