ZahcM @ZahcM
Cholesterol and dietary fat research. Author of "Why LDL Particles and Cholesterol Do Not Cause Disease" - https://t.co/wFfYjDhHFZ buymeacoffee.com/DietaryDiary Joined April 2019-
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👁️ 39 098 individuals follow‐up time of 11.8 years, with 4466 ASCVD events. 🤔 HIGH LDL‐C and LOW VLDL‐C experienced THE LOWEST CRUDE ASCVD rate (7.7 per 1000 person‐years) 🤔 LOW LDL‐C and HIGH VLDL‐C experienced the highest crude ASCVD rate (16.9 per 1000 person‐years).
"In our cohort, the risk for T2D was not associated with intake of meat in the adjusted analyses . . . a recent meta-analysis of randomized controlled trials did not support a mechanistic link between red meat intake and T2D risk factors." nature.com/articles/s4159… @fleroy1974
"Results from the replacement models should be interpreted with caution, as these were obtained from statistical models using dietary intakes in the study population and were not actual replacements. Therefore, causal relations cannot be inferred."
"Results from the replacement models should be interpreted with caution, as these were obtained from statistical models using dietary intakes in the study population and were not actual replacements. Therefore, causal relations cannot be inferred."
Our latest paper on #Lipids derived from red #wine, #beers and their dealcoholized variants izab.net/blog/lipids-de… @Diageo_News @DiageoEU @Heineken @ S.A. Vina Santa Rita #Guinness #Stout #Lager #cabernetsauvignon @ZahcM @drdairy50 @DipakRamji5 @el_ronan
A new piece on saturated fat! By @marynewportmd who has been writing on this topic, esp. coconut oil, ketones, and Alzheimers since 2011. This is an original piece with a lot of great scholarship. I do apologize for suggesting otherwise. I should have read it more closely!🙏🙏…
At this point I must agree. I tried to find evidence of the alleged plagiarism and could not find it.
"Our findings may indicate that contrary to people's expectations, low LDL level may not confer benefits and could potentially be detrimental." 🤔
"Our findings may indicate that contrary to people's expectations, low LDL level may not confer benefits and could potentially be detrimental." 🤔
"Dietary guidelines should reconsider its support for the lipid-heart hypothesis and its longstanding warnings against saturated fat . . . The lipid-heart hypothesis should not be used in the formulation of dietary guidelines." A great read. preprints.org/manuscript/202…
"The sdLDL-c [small dense LDL-c] subfraction is a risk factor for CAC incidence but not progression. The lbLDL-c [large buoyant LDL-c] is not associated with CAC incidence but may be inversely associated with CAC progression." @DudzLightLime
"The sdLDL-c [small dense LDL-c] subfraction is a risk factor for CAC incidence but not progression. The lbLDL-c [large buoyant LDL-c] is not associated with CAC incidence but may be inversely associated with CAC progression." @DudzLightLime https://t.co/fgkP2HAKd0
"There is no solid scientific basis for the hypothesis that reducing red meat consumption is beneficial for overall health."
"There is no solid scientific basis for the hypothesis that reducing red meat consumption is beneficial for overall health."
From our latest paper: bmjopen.bmj.com/content/14/3/e… "There is an overall lack of consensus on the magnitude and statistical and clinical interpretation of the reduction in mortality risk potentially achieved with the use of LDL-C lowering therapies. Multiple reviews suggest that…
Nice paper by @LDLSkeptic and colleagues. "The lowest risk for long-term mortality appears to exist in the wide LDL-C range of 100–189 mg/dL, which is much higher than current recommendations." bmjopen.bmj.com/content/14/3/e…
The @society_eas has this famous 2020 paper on LDL causing ASCVD (often cited by Dr Alo) and if you look up their source 73 we get this quote: "Because of their abundance, linoleate-containing lipid esters therefore represent the major substrate for lipid peroxidation in all LDL…
"In the continuous analysis, RC [remnant cholesterol] was associated with higher all-cause mortality. LDL-C was associated with lower all-cause mortality and cardiovascular death. Both did not show an association with ischemic stroke or recurrent MI." academic.oup.com/eurjpc/advance…
P. D. Mangan Health &.. @Mangan150
257K Followers 805 Following Microbiologist, age 69. Helped 1200+ @ManganCoaching clients get lean, fit, & 2X energy in 60 mins/week without keto, cardio, or calorie-counting. Learn more:
Marion Holman @holmanm
44K Followers 9K Following Diet & lifestyle over pharma drugs. My info is for educational and informational purposes only, and does not constitute medical advice. NO DM's please
Nina Teicholz, PhD @bigfatsurprise
160K Followers 2K Following Science journalist, Ph.D. in nutrition, author of The Big Fat Surprise, advocate for nutrition policy based on rigorous science, mom.
Ivor Cummins @FatEmperor
239K Followers 11K Following Technical Manager / Team Leader, Biochemical Engineer, Complex Problem Solving Specialist, Technologist, WW2 and Psychology buff. My Pronouns: We/The/People
Dave Feldman @realDaveFeldman
76K Followers 610 Following Engineering / Lipidology / Citizen+Formal Science 🎗 https://t.co/tKrrIdYbcn (501c3) 🟡 https://t.co/EhKewu6oLH 🩸 https://t.co/D1LrI2vCWq
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Tucker Goodrich @TuckerGoodrich
26K Followers 489 Following 'The plural of anecdote is data' —George Stigler, Nobel Prize in Economics | ぴん ぴん ころり—Pin Pin Korori —'healthy until you drop dead' | Consult @ZeroAcreFarms
David Diamond @LDLSkeptic
41K Followers 765 Following Ph.D. in Biology/Neuroscience Professor, Univ So Florida My second career focuses on cardiovascular disease I'm skeptical of LDL cholesterol as a cause of CVD
Frédéric Leroy @fleroy1974
27K Followers 987 Following Agri-food scientist + CDP activist (Common sense, Decency & Pragmatism) Tweets reflect my own views
Raphael Sirtoli @raphaels7
8K Followers 920 Following Senior Medical Researcher at Ancestralize (a health app) & Chief Scientist at Clinica Pêro (a medical clinic) https://t.co/KwIrcT7PX7. Views are my own
Amy Berger @TuitNutrition
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Recovering Vegan @VeganRecovering
18K Followers 4K Following Recovering from 18 years of #vegan #malnutrition #autoimmunedisease and #IBD on #carnivorediet-- one steak at a time.
dr roth ⓀⒸ @mrc314
9K Followers 170 Following #MGoBlue 〽️ How can I help? Count carbs, not calories! If you knew you weren't going to wake up in the morning, would you be on here doing what you're doing?
Shashi Iyengar | Accr.. @shashiiyengar
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Gabor Erdosi 🧩📄.. @gerdosi
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Valerie, RD, MPH @RDValerie
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no @nullbotto
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food is much more to .. @still_secrets
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DoctorTro @DoctorTro
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Dr Aseem Malhotra @DrAseemMalhotra
602K Followers 3K Following Cardiologist,campaigner,best selling author.On a mission to save lives with REAL evidence based medicine & REAL food.Tweets personal opinion,NOT medical advice
Ken D Berry MD @KenDBerryMD
211K Followers 1K Following Physician fighting to END Chronic Disease Epidemics caused by Hyperinsulinemia with a #ProperHumanDiet Read LIES MY DOCTOR TOLD ME because: https://t.co/Jvm5TSsHVi
Marion Holman @holmanm
44K Followers 9K Following Diet & lifestyle over pharma drugs. My info is for educational and informational purposes only, and does not constitute medical advice. NO DM's please
Nina Teicholz, PhD @bigfatsurprise
160K Followers 2K Following Science journalist, Ph.D. in nutrition, author of The Big Fat Surprise, advocate for nutrition policy based on rigorous science, mom.
Ivor Cummins @FatEmperor
239K Followers 11K Following Technical Manager / Team Leader, Biochemical Engineer, Complex Problem Solving Specialist, Technologist, WW2 and Psychology buff. My Pronouns: We/The/People
Dave Feldman @realDaveFeldman
76K Followers 610 Following Engineering / Lipidology / Citizen+Formal Science 🎗 https://t.co/tKrrIdYbcn (501c3) 🟡 https://t.co/EhKewu6oLH 🩸 https://t.co/D1LrI2vCWq
Chris S. Cornell @BiggestComeback
47K Followers 6K Following Weighed 278 lbs. Lost 80. Writer, photog. VP, Digital @WowProduction. Lift & run (26.2) Cancer survivor. 59 yo. #lowcarb #keto Accredited MHP, @TheSMHP
Dr Zoe Harcombe, PhD @zoeharcombe
200K Followers 665 Following I was interested in diet & health, and sometimes Wales & rugby. I still am, but I’m more interested in WTF is happening to the world!
Vinay Prasad MD MPH @VPrasadMDMPH
287K Followers 4K Following Prof @ucsf, Physician-Scientist, IG @vprasadmdmph @vkprasadlab @plenary_session, YouTube, #vpzd podcast & @Sensible__Med; Views mine
Dr. E @DrEenfeldt
51K Followers 337 Following Let #satiety free us from poor metabolic health caused by ultra-processed foods. Andreas Eenfeldt, MD, founder/CEO @JoinHava @DietDoctor.
Tucker Goodrich @TuckerGoodrich
26K Followers 489 Following 'The plural of anecdote is data' —George Stigler, Nobel Prize in Economics | ぴん ぴん ころり—Pin Pin Korori —'healthy until you drop dead' | Consult @ZeroAcreFarms
Carnivore Aurelius ©.. @AlpacaAurelius
344K Followers 482 Following Experimenting... Link below for zero glyphosate collagen and beef liver crisps. Not medical advice.
David Diamond @LDLSkeptic
41K Followers 765 Following Ph.D. in Biology/Neuroscience Professor, Univ So Florida My second career focuses on cardiovascular disease I'm skeptical of LDL cholesterol as a cause of CVD
Frédéric Leroy @fleroy1974
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Seed Oil Disrespecter.. @SeedOilDsrspctr
77K Followers 69 Following Dr. K (physician), Health Propagandist (the good kind). ”Not Medical Advice”. Wife: @RealOilRspctr (wholesome). Seedy App Now Available iOS and Android
no @nullbotto
52 Followers 50 Following story collector, "Israeli Paradox" survivor. Optimistic Pharma enthusiast Mitochondria enjoyer
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39 Followers 144 Following A 2x certified nutrition coach and elite personal trainer who is obsessed with the ketogenic lifestyle & helping people change their lives with nutrition.
Eric @EricKentEdstrom
165 Followers 220 Following Novelist. Guitarist. Dad. Husband. Currently writing book nine of the epic fantasy series Starside Saga.
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Mary Newport MD @marynewportmd
999 Followers 52 Following 71 yo physician, caregiver of husband with Alzheimer's; author What If There Was a Cure for Alzheimer's Disease and No One Knew? Speaker worldwide on ketones
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2K Followers 397 Following Nutrióloga clínica & renal • Maestra en nutrición clínica (INSP/INPer) • Especial amor por los riñones • Atención nutricional presencial, online y hospitalaria.
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@ZahcM @nullbotto What’s known about astaxanthin supplements and oxidizedLDL? Should future pharmaceutical research be focusing on reducing oxidization regardless of total LDL?
@ZahcM @nullbotto @SeedOilDsrspctr Might be a clue to why ApoE4 only seems to correlate with increased NCDs in a western diet context where these sterols are much more present in the diet 😉🤫
I often receive questions about phytosterols & their probable connection to Atherosclerosis. #plant-based adherents often promote these plant sterols for their lowering effect. If these sterols are PER SE atherogenic, that seems quite DANGEROUS. A look at the evidence 1/12
@DanClintonRN @ZahcM Riddock and Dayspring have their "argument from authority" down solid. That makes them the real deniers in my book. "Denier": Is it really LDL? "Lipidosaurs": YES! D: Show me L: You're dangerous and too stupid to understand D: So you can't show me L: 🤬@*#&$^ Pathetic.
Here’s why the human trials claiming seed oils prevent fatty liver disease are extremely misleading. 🧵
@ZahcM @DanClintonRN They say "denialists" like it's a bad thing. 🤨
And without measuring ApoB, this study “only proves apoB is better measure vs LDLc.” Someone who uses the word denialist contorts reality like this. That tells you all you need to know.
We found the problem @ZahcM The results weren’t adjusted enough :)
@Drlipid @drpablocorral @MohammedAlo @Lipoprotein &others LDLc/apoB & LLT denialists use this recent study as their "argument", guess we need some response to this? As I see it: only proves apoB is better measure vs LDLc +not sure results were adjusted for all they should be🤔
@SeedOilDsrspctr @ZahcM Have you seen this? Plant sterols getting a positive coverage, while subjects with apoE4 (Bad news for Alzheimer's) absorb them better.
@SeedOilDsrspctr Idk about these plant sterol things. nature.com/articles/pr200…
@ZahcM And they essentially make the same mistake. They say “LDL-C/amyloid/HIV does or does not cause disease after a totally variable latency thru unknown mechanisms.” Can’t be falsified.
@ZahcM There are lots of those. See Alzheimer’s (no definition after 113 years) and AIDS (a pure tautological definition since 1985).
They’ve gone from total cholesterol to total cholesterol to HDL ratio to LDL-C to ApoB and in 15 years they’ll go to some subfraction of ApoB then intermediate-density lipoproteins then to X then to Y then to Z but they’ll never realize they’re fundamentally wrong failures.
Ah yes. When a study found those with high VLDL and low LDL-C had the highest rates of ASCVD it’s a “faulty study” because it didn’t measure the latest metric lipidologists have shifted their livelihoods too. They’re pathetic failures as people, scientists, and physicians.
Nothing new here - that type of discordance would suggest the presence of remnant LP - but why in the world was apoB not reported - was it not measured? Faulty study
@PearRational @ZahcM Gotta check on the glycocalyx. Oxidized negatively charged crap shouldn't be making it past its negative surface charge.
@ZahcM I‘m think we can’t completely ignore LDL bc whether high/low PUFA, some amount is going to be oxidized and drive atherosclerosis. And not sure oxidation rates in vitro correlates to in vivo. It may be more related to residence time/turnover rate in the blood than composition.
@AlexJLeaf @TheNutrivore @raphaels7 @DrEenfeldt @tednaiman @realDaveFeldman Nick Hubert 🤮 is a complete coward anyway. Bart extended him an open invitation to discuss whatever topic he wanted to in a debate and he declined. Nicky boy is only looking to verbally abuse anyone not wise to his tactics. Stop defending him Alex you’re better than that.
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