#CELLFIE for CAR T screening, out in @Nature today—a new mRNA-based platform for screening primary cells. CAR + gRNA library are delivered by lentivirus, CRISPR modifiers as electroporated mRNA. That’s more flexible and effective than existing T cell screening methods. (1/7)
A vaccine candidate derived from highly conserved regions of the SARS-CoV-2 spike, nucleocapsid, and membrane proteins elicited successful immune responses in hamsters. Vaccine candidates like this are key for evolving virus variants.
🔗 ow.ly/YntZ50WY8Kn#OpenAccess
My new review article covers key points I have not seen in any other review of cancer immunotherapy: i) the difference between IFN-a and IFN-b; ii) the unique role of P1 pDC among all DC subsets; iii) the unique role of TLR7/8/9 nam10.safelinks.protection.outlook.com/?url=http%3A%2…
Mouse preprint via Thomas Jefferson Med School, Phildelphia
“The mRNA-LNP-based SARS-CoV-2 vaccine is highly
inflammatory, and its synthetic ionizable lipid component responsible for the induction of
inflammation has a long
in vivo half-life.”
biorxiv.org/content/10.110…
mRNA-, adenovirus vector-, and protein-based #COVID19#vaccines have distinct effects on lymph node stromal cell gene expression and function, according to a recent study in mice. Learn more in Science #Immunology: scim.ag/4oHFi7Q
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