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Mitch Murdock @mhmurdock1

Joined November 2009
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Mitch Murdock retweeted
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Hermany Munguba @hermanymv

2 months ago

@mhmurdock1 strikes again! Congratulations Mitch 🥳🥳

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MIT Picower Institute @MIT_Picower

2 months ago

@mhmurdock1 strikes again! Congratulations Mitch 🥳🥳

Mitch Murdock retweeted
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MIT Picower Institute @MIT_Picower

2 months ago

In @Nature today: 40Hz light and sound stimulation increases peptide release from interneurons, driving clearance of #Alzheimers protein via the brain’s glymphatic system. Study led by @DrLiHueiTsai, @mhmurdock1. picower.mit.edu/news/how-senso… @MitScience @mitbrainandcog

Mitch Murdock retweeted
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Mohamad Amki @mohamad_elamki

3 months ago

In our new study, we used fluorescent Localization microscopy to generate Hemodynamic maps of the whole Pial & Calvarial vascular connectome. Here, we used Pia-Flow in stroke, other applications for this transcranial powerful microscopy? #Topology #Velocity #direction #diameter

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bioRxiv @biorxivpreprint

3 months ago

In our new study, we used fluorescent Localization microscopy to generate Hemodynamic maps of the whole Pial & Calvarial vascular connectome. Here, we used Pia-Flow in stroke, other applications for this transcranial powerful microscopy? #Topology #Velocity #direction #diameter https://t.co/H6af0vlop2

Mitch Murdock retweeted
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Vishnu Dileep @vishnudileep200

7 months ago

Excited to share our work, out today @CellCellPress. We show that DNA double-strand break accumulation leads to mosaic gene fusions and 3D genome disruption in human samples and mouse models with Alzheimer's disease pathology. cell.com/cell/fulltext/…

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

Lucky to have been part of this amazing team (🙌🏻), and to have had a chance to contribute to this body of work across several papers! Check the story from @MIT_Picower summarizing all our findings: picower.mit.edu/news/decoding-…

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

This issue of Cell comes with 3 other papers from collaborations across the labs of @DrLiHueiTsai @manoliskellis 🔥🔥🔥 Check out the cover art designed by our very own Carles Boix!

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

Through differential gene expression, we report transcriptional changes of microglial states in a disease-stage specific manner! We define the enrichment of microglial inflammatory and lipid processing states, at the expense of surveillance states in the human AD brain!

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

We build a network of master transcription factors (TFs) poised to dictate microglial states and their transitions in Alzheimer's disease (AD)! We demonstrated the activity of key TFs in the induction of microglial states through ectopic expression or CRISPRi in iPS-microglia!

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

Through snATAC-seq, we noticed that microglial state heterogeneity is much higher at the transcriptional level than at the chromatin accessibility level! One idea is that microglia may retain a relatively permissive chromatin landscape to allow for dynamic state transitions.

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

Together, @nasun818 and I combined the power of this snRNA-seq data with in vitro modeling using iPSCs to leverage the transcriptomes of 152,459 in silico sorted microglia for functional studies on microglial state dynamics. Interact with the data here: compbio.mit.edu/microglia_stat…

Mitch Murdock retweeted
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Matheus Victor @MatBVictor

7 months ago

What do you do when you have 2.3 million single-cell transcriptomes from 427 human brains with varying degrees of AD pathology? You spend 3 years exploring the microglia cluster obviously!!💁🏻‍♂️ Excited to share our work out today @CellCellPress ! cell.com/cell/fulltext/…

Mitch Murdock retweeted
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Rachel Bennett @RBennett_PhD

a year ago

New pre-print! Are endothelial cells from different brain regions all the same? How are they impacted by the temporal progression of AD pathology? We wanted to know and performed a giant snRNAseq study using 5 different cortical areas 1/3 biorxiv.org/content/10.110…

Mitch Murdock retweeted
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Jennifer Strahle, MD @strahleMD

a year ago

Thrilled to share our work led by @PanShelei on region-specific CSF circulation in the developing brain - out today in @NatureComms. This has implications for neuron-CSF interactions and cognitive outcomes in #hydrocephalus @WashUNeurosurg @WUSTLmed go.nature.com/3JlD4IM

Mitch Murdock retweeted
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Natasha Harvey @DrNatashaHarvey

a year ago

Super excited to share our work identifying an enhancer regulating Prox1 expression, lymphatic identity and the ability of lymphatic endothelial cells to produce haematopoietic cells, published online today in @Nature! An amazing team effort! nature.com/articles/s4158…

Mitch Murdock retweeted
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Osama Harraz @OsamaHarraz

2 years ago

Check out our work. Just published in @CircRes! Piezo1 is a Mechanosensor Channel in Central Nervous System Capillaries ahajournals.org/doi/10.1161/CI… [🧵⬇️]

Mitch Murdock retweeted
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Tom Longden @_TomLongden

a year ago

Delighted to end 2022 with our first paper out today in @CellReports, and our image on the cover! Huge congratulations to first author Ashwini Hariharan!! We show #brain #pericytes increase blood flow to decreased local energy availability to preserve energy supply to #neurons.

Mitch Murdock retweeted
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Eric Topol @EricTopol

a year ago

Unraveling #Alzheimer's disease by single-cell genomics, a new tour de force review nature.com/articles/s4159… @NatureNeuro @mhmurdock1 @DrLiHueiTsai @MIT

Mitch Murdock retweeted
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Li-Huei Tsai @DrLiHueiTsai

a year ago

Excited to start 2023 with a new review paper in @NatureNeuro with grad student @mhmurdock1 in which we highlight 5 pathways that single-cell profiling has shown become perturbed in each of 5 major cell types in Alzheimer's disease. picower.mit.edu/news/new-techn…

Mitch Murdock retweeted
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Rachel Babij @rachelbabij

a year ago

So excited that this study is finally out in @NeuroCellPress! @AliciaYChe @amandambuch @Ben_S_Huang @TedSchwartz13 authors.elsevier.com/a/1g9qX3BtfH1Z…

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Weill Cornell Medicine @WeillCornell

a year ago

So excited that this study is finally out in @NeuroCellPress! @AliciaYChe @amandambuch @Ben_S_Huang @TedSchwartz13 authors.elsevier.com/a/1g9qX3BtfH1Z…

Mitch Murdock retweeted
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Leyla Akay @leyla_aakay

a year ago

I am so excited to share my first first-author paper, out today @Nature!! So thankful to work with three other amazing first-authors @JoelWBlanchard1 @_josedavila and Djuna von Maydell, and an inspiring team lead by @DrLiHueiTsai 🤩🔥 nature.com/articles/s4158…

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