Jinwei Zhang Lab @jinweizhang
RNA structural biology lab at NIH; believes #RNA lives and interacts in 3D space. All views my own. www-mslmb.niddk.nih.gov/zhang/zhanglab… Bethesda, MD Joined June 2009-
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Jinwei Zhang Lab retweeted
Happy to share that we identified a conserved 17kb long-range RNA-RNA interaction in SARS-CoV-2 that impacts virus fitness. Congratulations to all the authors! nature.com/articles/s4146…
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Jinwei Zhang Lab retweeted
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The…
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The… https://t.co/GpqBYQtWtz
Jinwei Zhang Lab retweeted
New paper in JACS: we show covalent chemistry isn’t just for proteins — it can make selective RNA-targeting small molecules. Found that 3-chloropivalamides crosslink RNA and used it to design a covalent binder of r(CUG) repeats in DM1. 🔗 doi.org/10.1021/jacs.5…
Jinwei Zhang Lab retweeted
Postdoctoral Researcher (Ding-Dean Group) | John Innes Centre jic.ac.uk/vacancies/post…
Jinwei Zhang Lab retweeted
Please join us for the Inaugural Brown RNA Center Symposium with a Keynote Speakers Melissa Moore and Craig Mello, guests Victor Dzau, Jack Reed and Subra Suresh, as well as more talks and panels including both scientific and industrial speakers and panelists. The Warren Alpert…
Jinwei Zhang Lab retweeted
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
Jinwei Zhang Lab retweeted
A biphenyl-like scaffold targets RNA through a common base displacement mechanism by optimizing pi-stacking interactions within the binding pocket, helping to inform the design of novel RNA-targeting small molecules nature.com/articles/s4158…
Jinwei Zhang Lab retweeted
A new #KwokLab paper has been released in Genome Biology: "DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights." Congrats to the author! doi.org/10.1186/s13059… @CityUHongKong @CityUChem @CityUScience @GenomeBiology
Jinwei Zhang Lab retweeted
excited to join this panel for a free webinar on the journal editor career path hosted by Life Science Editors, coming up on October 7. scan the QR code in the image or visit lifescienceeditors.com to learn more and register!
Jinwei Zhang Lab retweeted
New online! tRNA as an assembly chaperone for a macromolecular transcription-processing complex bit.ly/42cF5Qb
Jinwei Zhang Lab retweeted
Great start to the 3rd day of @MeetingRna with RNA Binding Proteins session! Invited talks from @woodson_lab on Hfq-driven kinetic selection of sRNA targets and @KatieBerryRNA on bacterial KH-domain proteins set the stage for a series of exciting selected talks. #RNA2025
Jinwei Zhang Lab retweeted
Congratulations to @AlexBoRNA who presented the 2025 Colworth Medal Lecture today! Alex discussed how his work positions viral replication organelles as tractable systems for dissecting the biophysical principles underpinning RNA selection and turnover #BiochemAwards
Jinwei Zhang Lab retweeted
Our September issue is live! nature.com/nchembio/volum… The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
Jinwei Zhang Lab retweeted
Collaboration with M.G.Finn’s group at @GeorgiaTech ! We present protein nanocrates—icosahedral cages that protect samples from the air–water interface, a major source of artifacts in cryo-EM. A widely applicable solution to preferred orientation! biorxiv.org/content/10.110…
Jinwei Zhang Lab retweeted
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal : embopress.org/doi/full/10.10…
Jinwei Zhang Lab retweeted
My lab's very first manuscripts are out!!! - We identified nearly 60 conserved #RNA structures in plastids - We found that transcriptional response to warm temperatures in whole seedling is confounded by response at organ level #thermomorphogenesis Link to both preprints below
Jinwei Zhang Lab retweeted
A comprehensive statistical analysis of how Q-scores are related to reported resolution, based on ∼10 000 EMDB maps and associated PDB atomic coordinate models archived in the EMDB @UCSanDiego @ActaCrystD @IUCr #CryoEM #QScores #Validation doi.org/10.1107/S20597…
Jinwei Zhang Lab retweeted
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵 rdcu.be/eBwPJ
Jinwei Zhang Lab retweeted
We are pleased to share our paper "Structures and mechanisms of U6 snRNA m6A modification by METTL16” Nature Communications doi.org/10.1038/s41467…
Jinwei Zhang Lab retweeted
Disulfide-based dimerization of modified nanobody scaffolds enables higher-order assembly for high-resolution cryo-EM structure determination that is widely applicable to small protein targets nature.com/articles/s4158…
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