Torstein Martinsen Coaching @Torstein1982
Taking you to the next level 🔶Value determination 🔶Personal Development Coach Oslo, Norge Joined July 2011-
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The relationship of #Omega3 fatty acids with #Dementia and cognitive decline: (@ADNI3study + prospective cohorts): "Our findings support the hypothesis that the efficacy of omega-3 fatty acid supplementation is dose-dependent. We found that omega-3 fatty acid supplementation was significantly associated with a decreased risk of #Alzheimers, particularly among long-term users. The risk of cognitive decline decreased when the intake of omega-3 fatty acids exceeded 1.0 g/d. For this reason, we propose that 1.0 g/d may be the threshold dosage of omega-3 fatty acids for the prevention of cognitive decline." sciencedirect.com/science/articl…
Har nettopp publisert et bilde instagram.com/p/CqUvJd1KbJh/…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab @AlwaysOmega3s @FariOmega3 @foundmyfitness @humanageing @USherbrooke @uk_biobank @NgaleHealth @NatureComms And @UriAlonWeizmann/@IdoAmitLab shows #Rejuvenation strategies converge on reduced inflammation & restored fatty acid metabolism. "Argues in favor of directly targeting inflammation & fatty acid metabolism pathways to mitigate age-related health decline." biorxiv.org/content/10.110…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab @AlwaysOmega3s @FariOmega3 @foundmyfitness @humanageing @USherbrooke @uk_biobank @NgaleHealth @NatureComms @CNSerhanLab: #ResolutionMedicine: are we on track to address the next Pandemic (& #Aging)? link.springer.com/article/10.100… A new high-sensivity method for measuring #Oxylipins/#SPMs: jlr.org/article/S0022-… And #Maresin2 (DHA) is another pro-repair molecule: pnas.org/doi/10.1073/pn…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab @AlwaysOmega3s @FariOmega3 @foundmyfitness @humanageing @USherbrooke A new large Atlas of 249 plasma biomarkers for health & disease in 118,461 individuals from the @uk_biobank confirms #Omega3 levels are at top for #AntiAging/disease. The findings were replicated in 5 cohorts in Finland with over 30 000 individuals. nature.com/articles/s4146…
Har nettopp publisert et bilde instagram.com/p/Cn8_hA-qQ6u/…
@jacobmhands @JuliaB_fitness @camillebesse @foundmyfitness @DrMorganLevine We now have reasons to suspect that rTG-form #Omega3 may be substantially more potent for Anti-inflammatory effects than other Omega-3 forms. May be especially important regarding #DHA and all-important #NFkB targets for #AntiAging. More to come, also see: lipidworld.biomedcentral.com/articles/10.11…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab Happy 2023, new #Omega3 & #Cognition review shows the complexity of Omega-3 studies. Most used low doses & many studies using low potency/quality products but ~70% of RCTs with MCI patients reported improved cognitive scores compared to placebo. #AntiAging sciencedirect.com/science/articl…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab Merry Xmas to everyone🎄and an excellent recent review on #Omega3's as #Antiaging #NRF2 inducers. "N-3 PUFA & their metabolites may be recognized as potential agents to restore cellular redox state, slow down aging & prevent age-related pathologies."🧬 sciencedirect.com/science/articl…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab #Omega3 - The multipoint anti-inflammatory strategy. Enormous anti-inflammatory signal convergence important for #Antiaging: GPR120/PPARγ activation → Blocks multilevel #NFkB activity + #NLRP3 blockade, Macrophage regulation, SPMs & more. tandfonline.com/doi/10.1080/10…
@eatshitdork @philosophising4 @yeeseak @ItsJakePerry @adkaspr @biogerontology @PeterAttiaMD @JuliaB_fitness Some good (international) news coming soon!👍
@Philosophising4 @yeeseak @ItsJakePerry @adkaspr @biogerontology @PeterAttiaMD @JuliaB_fitness We have the same experience (many individuals). #ChronicInflammation must seemingly be counteracted/resolved continuously & the enhanced tissue regeneration we've observed is also likely mediated 24/7 with chronic SPM elevation etc. ncbi.nlm.nih.gov/pmc/articles/P… x.com/npure3/status/…
@rhg_1 @JuliaB_fitness @foundmyfitness @AnnualReviews @CNSerhanLab @Kat_Arney New RCT confirms our hypothesis & previous research, #SPMs/#Resolvins increases in humans in a dose & time-dependent manner after #Omega3 supplementation. 4 g EPA (+~1,2 g DHA) /day led to far higher plasma levels of EPA/DHA & SPM's (including Lipoxin B4). sciencedirect.com/science/articl…
@CNSerhanLab @JuliaB_fitness @foundmyfitness @rhg_1 @AnnualReviews @NatRevNeph "We found that DHA supplementation markedly increased the levels of GDNF & GFRα1 and phosphorylation of RET in hippocampus tissue." tandfonline.com/doi/full/10.31… Age-associated decrease in GDNF and its cognate receptor GFRα-1 protein expression in human skin. onlinelibrary.wiley.com/doi/10.1111/ie…
@CNSerhanLab @JuliaB_fitness @foundmyfitness @rhg_1 @AnnualReviews @NatRevNeph "Given the presence of conserved genes in species with high and low regenerative capacity, it is likely that less-regenerative organisms can regenerate tissues and organs if provided with the appropriate lineage-specific factors & induction of conserved gene regulatory programs."
@CNSerhanLab @JuliaB_fitness @foundmyfitness @rhg_1 @AnnualReviews @NatRevNeph Reawakening #GDNF's Regenerative past in humans? "Activating GDNF-GFRα1 signaling may be a method of promoting complete limb & skin regeneration in less regenerative animals like humans." EPA/DHA #Omega3 are potent GDNF activators🧬 sciencedirect.com/science/articl… nature.com/articles/s4138…
@foundmyfitness @NatureAging @EricVerdin @AkbarLab @Dr_Epel Effect of #Omega3 Fatty Acids on Telomeres—Are They the Elixir of Youth? mdpi.com/2072-6643/14/1… Recent reviews also connects Telomere dysfunction & aging/chronic inflammation, chronic stress, DNA damage & mitochondrial dysfunction. nature.com/articles/s4155… sciencedirect.com/science/articl…
@onelifemax @mollymaloofmd #Omega3 effects on 18-HEPE etc and their downstream mediators in vivo in humans are dose-dependent (but with individual heterogeneity). "A doubling of the omega-3 index correlated with increases of 2.3-fold in 18-HEPE; P < .0001)." lipidjournal.com/article/S1933-… x.com/npure3/status/…
@rhg_1 @JuliaB_fitness @foundmyfitness @AnnualReviews @CNSerhanLab @Kat_Arney New RCT confirms our hypothesis & previous research, #SPMs/#Resolvins increases in humans in a dose & time-dependent manner after #Omega3 supplementation. 4 g EPA (+~1,2 g DHA) /day led to far higher plasma levels of EPA/DHA & SPM's (including Lipoxin B4). sciencedirect.com/science/articl…
@mdpatrick @theSamParr @davidasinclair @JCIB_Lab_Salk @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab Small-molecule-mediated reprogramming: a silver lining for #RegenerativeMedicine. 2020 «The future direction of personalized medicine is through small molecules.» nature.com/articles/s1227…
@JuliaB_fitness @mdpatrick @theSamParr @davidasinclair @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab Earliest #AntiAging🧬Epigenetic Reprogramming Mediated by Maternal Diet Rich in #Omega3 Protects From Breast Cancer Development in F1 Offspring + "We showed Omega-3 has an inverse association with (human) newborn epigenetic aging." academic.oup.com/ajcn/article-a… frontiersin.org/articles/10.33…
@mdpatrick @JuliaB_fitness @thesamparr @davidasinclair @NUSMedicine @IRBBarcelona @AndreaBMaier @ResetYourClock @DrMorganLevine @LizRose14449371 @OcampoLab @Nature @Cell_Metabolism And a new EPA anti-inflammatory mechanism/target: New study shows EPA is a potent physiological blocker of #VNUT (vesicular nucleotide transporter) that potently alleviates neuropathic and inflammatory pain & insulin resistance. pnas.org/doi/full/10.10… nutritioninsight.com/news/better-th…
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