Rob Townley @RobTownley6
Moleculista. https://t.co/nuH2ql74VQ 0000-0002-9347-2431 https://t.co/WbJUHqy60I Joined May 2021-
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Here’s an example of what I’m talking about from Frank Harrell’s otherwise excellent critique of bad biomarker analysis [fharrell.com/post/badb/]. This gets GWAS completely wrong. Genome-wide significance is not about "picking winners" or "ranking" the losers.
The universe as a network of rivers: This remarkable new map reveals how galaxies flow like water, following the pull of gravity across hundreds of millions of light years. astrobites.org/2024/04/23/tem…
The answer is that the Israelis leading this genocide are not descendants of Holocaust survivors. Netanyahu's family wasn't even in Europe during the Holocaust. Ben Gvir's family wasn't in Europe. Smotrich's family wasn't in Europe. All of their families were settlers in…
The answer is that the Israelis leading this genocide are not descendants of Holocaust survivors. Netanyahu's family wasn't even in Europe during the Holocaust. Ben Gvir's family wasn't in Europe. Smotrich's family wasn't in Europe. All of their families were settlers in…
😮 This is so cool: “RNA polymerase II, which is responsible for mRNA transcription in eukaryotes, is also derived from the ancestors of modern giant viruses. In total, our results support a model of eukaryogenesis in which complex cells emerged from a genomic chimera of Asgard…
In UK Biobank, individuals who had high polygenic score for educational attainment but performed poorly in fluid intelligence test and/or had poor education ('deviators') were more likely to carry neurodevelopmental disorder-related rare variants. Great demonstration of liability…
I'm a #ColumbiaUniversity faculty member,. I join many of my colleagues in saying, loud and clear, that it was wrong to suspend peacefully protesting students, and wrong to call in the NYPD. Who disrupted education on campus last Thursday? The university's president.
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
Our decade-long search for the genetic traces of the earliest Indo-Europeans has culminated in the two preprints we are releasing today! With Nick Patterson, David Anthony, and 91 co-authors, on "The Genetic Origin of the Indo-Europeans" biorxiv.org/content/10.110…
We engineered hyper-migration into CART cells to dramatically enhance their infiltration into solid tumors. We tested this strategy for ovarian, lung, and pancreatic cancer. The contrast with control CAR T cells is ....you decide. More here: biorxiv.org/content/10.110…
Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases — a Review by Martin Kampmann (@MartinUCSF) go.nature.com/3JloKyM
Our paper “Investigating the role of cis-eQTLs in modifying the penetrance of putatively damaging, inherited variants in severe neurodevelopmental disorders” (NDDs) is out in Scientific Reports! Three interesting findings led to this study: nature.com/articles/s4159…
AI Video in Space by @Trl11_Inc 🎥 Streaming for satellites and remote robotics 🛰️ Spacecadet Fund I : 030 🚀
What is happening? The Atlantic circulation (Gulf Stream, etc.) appears likely to be close to a tipping point at which it would shut down, a big adverse effect of global warming. An excellent article discusses the evidence, the uncertainties, the effects. tos.org/oceanography/a…
Here is a AlphaFold/ColabFold tutorial we have recently presented - from basic to more advanced usage, enforcing alternative conformations, modeling interactions, and analysis with ChimeraX and PICKLUSTER. Maybe you find it helpful 🎓 ! Commenting enabled in the doc so feel free…
Today I recalled my talk from SCP2020. In some ways, it reflects a distant era. In other ways, it remains just as relevant in 2024. youtu.be/LkNMskjxYXA?si…
To @CDCgov Id love to read this article by @CDCDirector in @NEJM but alas it is out of reach to all but the wealthiest institutions When the CDC Director writes an important article, I would hope it would be in a format that is made available to all tax payers.…
I wouldn’t make the conclusions people are making… 🤷🏽♂️ pretty clear genetic association outperforms transcriptomics-based associations/discovery. If anything, the differences are further accentuated as one goes later in the clinical development process…
I’m about to do the Lumina treatment, a cure for dental cavities developed by Lantern Bioworks. I figured I’d do an unboxing and let you come with me on this journey. Here’s the box:
Ariella Lavalley @ariell_laval
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432 Followers 1K Following 🗽 Degenerate Artist 👹 Poet 🎭🎨📷 Rimbaud's lover ❤️🔥 #Neurodeficient wisdom 🐞🪬 The memes I make are fine art 🙏 Epistemic Usurper ⚔️ Feminist ✡️🖖@getnormality It’s when you’re presented with a set of facts or arguments and the conclusion that results from them and you’re able to figure out that the correct conclusion is actually something else.
@Bryce_Nickels I predict that @MJnanostretch will switch the odds from 52:48 to 48:52. 😀
@wanderer_jasnah The respect between the lecturer and the protester made me quite emotional actually
Applying a genetic screen in the model worm #CElegans, scientists demonstrate how an enzyme degrades a mutant protein linked to tumor progression—potentially informing strategies to block the protein’s signaling in #cancer. @UWMBioSci @ClairedelaCova scim.ag/42i
@butlerofdogs @Ayjchan A prerequisite for research is not knowing exact outcomes. That's why it's called research.
@RobTownley6 @ydeigin I guess the point is that people were looking at non-canonical FCSs.
@VBruttel @RobTownley6 @Biorealism @humblesci @leftyvegan @ryangrim This is just bizarre
@RobTownley6 @Ayjchan "...all bets are off after the grant gets written. Experimenters gonna experiment. " That's *exactly* what Ebright said in a recent article. And I have no reasons to disbelieve that. Thanks for the music link. I couldn't follow the lyrics but the overall sound is fantastic!
@Graybea71861266 IMO it's BS, but I'll wait for the proof. There better be something better than - he worked on some WIV1 chimera's in cooperation with EHA.
@MichaelWorobey @KatherineEban @jeffykao @propublica Ipsis verbis: quotations should be exact, regardless of their relevance 👍
For this thread I ignored my overcrowded mailbox, kicked my to-do-list out of sight and may have to stay up until late to finish some really urgent work Good night
@stuartjdneil @eLife I read this, nice analysis, but entirely orthogonal to the issue under discussion here.
@RobTownley6 @angie_rasmussen @PrometheusCHT @emmecola @humblesci @MichaelWorobey @K_G_Andersen @acritschristoph I don’t doubt that. But you also well know that making the construct and using it make and grow the virus is not the same thing.
@RobTownley6 And thank you for all your support, I had the best time and a steep learning curve! I am glad to see still the enthusiasm for research and nature everywhere
The Holy Fire Ceremony from the Church of the Holy Sepulcher in Jerusalem. Happy Easter to those celebrating.